Cannabaceae

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EGIS-12,233
Clinical data
ATC code
  • none
Identifiers
  • 5,7-dichloro-3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-indolin-2-one
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H28Cl3N3O
Molar mass480.86 g·mol−1
3D model (JSmol)
  • c3cc(Cl)ccc3N4CCN(CC4)CCCCC1(CC)c2cc(Cl)cc(Cl)c2NC1=O
  (verify)

EGIS-12,233 is a drug with applications in scientific research, acting as a potent and selective antagonist for both the 5-HT6 and 5-HT7 serotonin receptor subtypes, with good selectivity over other receptors.[1] It has been shown to increase dopamine release in cochlear tissue, suggesting a role for the 5-HT6 and 5-HT7 receptors in regulation of the hearing system.[2]

References[edit]

  1. ^ Volk B, Barkóczy J, Hegedus E, Udvari S, Gacsályi I, Mezei T, et al. (April 2008). "(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists". Journal of Medicinal Chemistry. 51 (8): 2522–32. doi:10.1021/jm070279v. PMID 18361484.
  2. ^ Doleviczényi Z, Vizi ES, Gacsályi I, Pallagi K, Volk B, Hársing LG, et al. (November 2008). "5-HT6/7 receptor antagonists facilitate dopamine release in the cochlea via a GABAergic disinhibitory mechanism". Neurochemical Research. 33 (11): 2364–72. doi:10.1007/s11064-008-9796-4. PMID 18663573. S2CID 11148455.
source: https://en.wikipedia.org/wiki/EGIS-12,233

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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