Cannabaceae

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DR-4485
Identifiers
  • 6-chloro-2a-(4-[4-(4-chlorophenyl)-3,6-dihydro-1(2H)-pyridinyl]butyl)-2a,3,4,5-tetrahydrobenz[cd]indol-2(1H)one
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC26H28Cl2N2O
Molar mass455.42 g·mol−1
3D model (JSmol)
  • c4cc(Cl)ccc4C(CC5)=CCN5CCCCC2(CCC3)c1c3c(Cl)ccc1NC2=O
  • InChI=1S/C26H28Cl2N2O/c27-20-7-5-18(6-8-20)19-11-16-30(17-12-19)15-2-1-13-26-14-3-4-21-22(28)9-10-23(24(21)26)29-25(26)31/h5-11H,1-4,12-17H2,(H,29,31)
  • Key:SBTRHJHOLCAPFT-UHFFFAOYSA-N

DR-4485 is a compound which acts as a potent and selective antagonist for the 5-HT7 receptor, with good oral bioavailability. It has been used to research the function of this still comparatively little studied serotonin receptor subtype.[1][2]

References[edit]

  1. ^ Kikuchi C, Suzuki H, Hiranuma T, Koyama M (January 2003). "New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability". Bioorganic & Medicinal Chemistry Letters. 13 (1): 61–4. doi:10.1016/s0960-894x(02)00842-9. PMID 12467617.
  2. ^ Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML (April 2009). "Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity". Journal of Medicinal Chemistry. 52 (8): 2384–92. doi:10.1021/jm8014553. PMID 19326916.
source: https://en.wikipedia.org/wiki/DR-4485

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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