Cannabaceae

POLN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLN, POL4P, polymerase (DNA) nu, DNA polymerase nu
External IDsOMIM: 610887; MGI: 2675617; HomoloGene: 129696; GeneCards: POLN; OMA:POLN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181808

NM_001289803
NM_001289804
NM_181857

RefSeq (protein)

NP_861524

NP_001276732
NP_001276733
NP_862905

Location (UCSC)Chr 4: 2.07 – 2.24 MbChr 5: 34.16 – 34.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene.[5] It is a family A DNA polymerase,[6] considered to be the least effective of the polymerase enzymes.[7] However, DNA polymerase nu plays an active role in homology repair during cellular responses to crosslinks, fulfilling its role in a complex with helicase.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130997Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045102Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Polymerase (DNA directed) nu".
  6. ^ Marini F, Kim N, Schuffert A, Wood RD (August 2003). "POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308". The Journal of Biological Chemistry. 278 (34): 32014–9. doi:10.1074/jbc.M305646200. PMID 12794064.
  7. ^ a b "UniProtKB - Q7Z5Q5 (DPOLN_HUMAN)". Uniprot. Retrieved 5 July 2018.

Further reading[edit]

External links[edit]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA polymerase nu


One thought on “Cannabaceae

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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