Protein found in humans
This article is about the gene and encoded protein. For the Disease Control Priorities in Developing Countries Report (2nd edition), see
Disease Control Priorities Project .
mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene .[5] [6] [7]
DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM][7]
Interactions [ edit ] DCP2 has been shown to interact with DCP1A [8] UPF1 .[6] [9]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000172795 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024472 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (October 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme" . Proceedings of the National Academy of Sciences of the United States of America . 99 (20): 12663–12668. Bibcode :2002PNAS...9912663W . doi :10.1073/pnas.192445599 PMC 130517 PMID 12218187 . ^ a b Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay" . Molecular and Cellular Biology . 22 (23): 8114–8121. doi :10.1128/MCB.22.23.8114-8121.2002 . PMC 134073 PMID 12417715 . ^ a b "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)" .^ Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay" . Molecular and Cellular Biology . 22 (23): 8114–8121. doi :10.1128/MCB.22.23.8114-8121.2002 . PMC 134073 PMID 12417715 . ^ Lejeune F, Li X, Maquat LE (September 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities" . Molecular Cell . 12 (3): 675–687. doi :10.1016/S1097-2765(03)00349-6 PMID 14527413 .
Further reading [ edit ]
Ueno K, Kumagai T, Kijima T, Kishimoto T, Hosoe S (January 1998). "Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer". Human Genetics . 102 (1): 63–68. doi :10.1007/s004390050655 . PMID 9490301 . S2CID 36201527 . van Dijk E, Cougot N, Meyer S, Babajko S, Wahle E, Séraphin B (December 2002). "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures" . The EMBO Journal . 21 (24): 6915–6924. doi :10.1093/emboj/cdf678 . PMC 139098 PMID 12486012 . Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (December 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci" . RNA . 8 (12): 1489–1501. doi :10.1017/S1355838202021726 . PMC 1370355 PMID 12515382 . Grzymski EC (June 2003). "Visualizing an mRNA destruction line" . Nature Structural Biology . 10 (6): 416. doi :10.1038/nsb0603-416 PMID 12768200 . S2CID 40900780 . Piccirillo C, Khanna R, Kiledjian M (September 2003). "Functional characterization of the mammalian mRNA decapping enzyme hDcp2" . RNA . 9 (9): 1138–1147. doi :10.1261/rna.5690503 . PMC 1370477 PMID 12923261 . Lejeune F, Li X, Maquat LE (September 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities" . Molecular Cell . 12 (3): 675–687. doi :10.1016/S1097-2765(03)00349-6 PMID 14527413 . Cougot N, Babajko S, Séraphin B (April 2004). "Cytoplasmic foci are sites of mRNA decay in human cells" . The Journal of Cell Biology . 165 (1): 31–40. doi :10.1083/jcb.200309008 . PMC 2172085 PMID 15067023 . Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation" . Genome Research . 14 (7): 1315–1323. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Liu SW, Jiao X, Liu H, Gu M, Lima CD, Kiledjian M (September 2004). "Functional analysis of mRNA scavenger decapping enzymes" . RNA . 10 (9): 1412–1422. doi :10.1261/rna.7660804 . PMC 1370627 PMID 15273322 . Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (July 2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies" . Nature Cell Biology . 7 (7): 719–723. doi :10.1038/ncb1274 . PMC 1855297 PMID 15937477 . Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (December 2005). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping" . Molecular Cell . 20 (6): 905–915. doi :10.1016/j.molcel.2005.10.031 PMID 16364915 . Wichroski MJ, Robb GB, Rana TM (May 2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies" . PLOS Pathogens . 2 (5): e41. doi :10.1371/journal.ppat.0020041 PMC 1458959 PMID 16699599 . Chu CY, Rana TM (July 2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54" . PLOS Biology . 4 (7): e210. doi :10.1371/journal.pbio.0040210 PMC 1475773 PMID 16756390 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–648. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction