Cannabaceae

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Cinaciguat
Clinical data
Routes of
administration		intravenous (?)
ATC code
  • none
Identifiers
  • 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)
    phenyl]methoxy}phenyl)ethyl]amino}methyl)
    benzoic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC36H39NO5
Molar mass565.710 g·mol−1
3D model (JSmol)
  • c4ccccc4CCc3ccc(cc3)COc1ccccc1CCN(CCCCC(O)=O)Cc2ccc(C(=O)O)cc2
  • InChI=1S/C36H39NO5/c38-35(39)12-6-7-24-37(26-30-19-21-33(22-20-30)36(40)41)25-23-32-10-4-5-11-34(32)42-27-31-17-15-29(16-18-31)14-13-28-8-2-1-3-9-28/h1-5,8-11,15-22H,6-7,12-14,23-27H2,(H,38,39)(H,40,41) ☒N
  • Key:WPYWMXNXEZFMAK-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Cinaciguat (BAY 58-2667) is an experimental drug for the treatment of acute decompensated heart failure.

Mechanism of action

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Cinaciguat activates the soluble guanylate cyclase (sGC) which is a receptor for nitric oxide. This increases biosynthesis of cyclic GMP, resulting in vasodilation.[1]

See also

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  • Riociguat, another drug stimulating sGC, but with a different mechanism
  • PDE5 inhibitors act further downstream in the nitric oxide signalling pathway, reducing cyclic GMP degradation.

References

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  1. ^ Schubert-Zsilavecz, M, Wurglics, M, Neue Arzneimittel 2009



source: https://en.wikipedia.org/wiki/Cinaciguat

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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