Cytochrome P450, family 12, also known as CYP12, is a cytochrome P450 family found in insect genome belongs to Mitochondrial clan CYPs, which is located in the inner membrane of mitochondria(IMM).[1][2] The first gene identified in this family is the CYP12A1 from the Musca domestica (house fly), which is involved in insecticide resistance.[3] CYP12A1 protein localization in mitochondria by immunohistochemistry and absolute dependence on mitochondrial electron donors adrenodoxin reductase and adrenodoxin.[3]
Rabbit gene CYP8B1 was named CYP12 at the beginning of its discovery, because it hydroxylated its sterol substrate on the 12 position.[4] However, CYP12 is a family of insect P450s found in mitochondria, so this gene was renamed to CYP8B1.[5]
References
[edit]- ^ Nelson, DR (November 1998). "Metazoan cytochrome P450 evolution". Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology. 121 (1–3): 15–22. doi:10.1016/s0742-8413(98)10027-0. PMID 9972448.
- ^ Tijet, N; Helvig, C; Feyereisen, R (10 January 2001). "The cytochrome P450 gene superfamily in Drosophila melanogaster: annotation, intron-exon organization and phylogeny". Gene. 262 (1–2): 189–98. doi:10.1016/s0378-1119(00)00533-3. PMID 11179683.
- ^ a b Guzov, VM; Unnithan, GC; Chernogolov, AA; Feyereisen, R (15 November 1998). "CYP12A1, a mitochondrial cytochrome P450 from the house fly". Archives of Biochemistry and Biophysics. 359 (2): 231–40. doi:10.1006/abbi.1998.0901. PMID 9808765.
- ^ Eggertsen, G; Olin, M; Andersson, U; Ishida, H; Kubota, S; Hellman, U; Okuda, KI; Björkhem, I (13 December 1996). "Molecular cloning and expression of rabbit sterol 12alpha-hydroxylase". The Journal of Biological Chemistry. 271 (50): 32269–75. doi:10.1074/jbc.271.50.32269. PMID 8943286. S2CID 84628848.
- ^ Nelson, DR (2006). "Cytochrome P450 Nomenclature, 2004". Cytochrome P450 Protocols. Methods in Molecular Biology. Vol. 320. pp. 1–10. doi:10.1385/1-59259-998-2:1. ISBN 1-59259-998-2. PMID 16719369.
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction