Protein-coding gene in the species Homo sapiens
CREB regulated transcription coactivator 2 , also known as CRTC2 , is a protein which in humans is encoded by the CRTC2 gene .[ 5] [ 6] [ 7]
CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of
gluconeogenic gene expression in response to cAMP .[ 8] STK11 (LKB1)-null non-small cell lung cancers (NSCLC ).[ 9]
CRTC2 has been shown to interact with SNF1LK2 [ 10] YWHAQ .[ 10] [ 11]
^ a b c GRCh38: Ensembl release 89: ENSG00000160741 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027936 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2" .^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells" . Proceedings of the National Academy of Sciences of the United States of America . 100 (21): 12147–52. doi :10.1073/pnas.1932773100 PMC 218727 PMID 14506290 . ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity" . Molecular Cell . 12 (2): 413–23. doi :10.1016/j.molcel.2003.08.013 PMID 14536081 . ^ Cheng A, Saltiel AR (March 2006). "More TORC for the gluconeogenic engine". BioEssays . 28 (3): 231–4. CiteSeerX 10.1.1.604.5745 doi :10.1002/bies.20375 . PMID 16479585 . ^ Rodón L, Svensson RU, Wiater E, Chun MG, Tsai WW, Eichner LJ, et al. (July 2019). "The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer" . Science Advances . 5 (7): eaaw6455. Bibcode :2019SciA....5.6455R . doi :10.1126/sciadv.aaw6455 . PMC 6656544 PMID 31355336 . ^ a b Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector" . Cell . 119 (1): 61–74. doi :10.1016/j.cell.2004.09.015 PMID 15454081 . S2CID 18616459 . ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 .
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, et al. (October 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells" . Proceedings of the National Academy of Sciences of the United States of America . 100 (21): 12147–52. doi :10.1073/pnas.1932773100 PMC 218727 PMID 14506290 . Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (August 2003). "TORCs: transducers of regulated CREB activity" . Molecular Cell . 12 (2): 413–23. doi :10.1016/j.molcel.2003.08.013 PMID 14536081 . Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, et al. (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Current Biology . 14 (16): 1436–50. Bibcode :2004CBio...14.1436J . doi :10.1016/j.cub.2004.07.051 PMID 15324660 . S2CID 2371325 . Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector" . Cell . 119 (1): 61–74. doi :10.1016/j.cell.2004.09.015 PMID 15454081 . S2CID 18616459 . Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, et al. (December 2005). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science . 118 (Pt 23): 5661–73. doi :10.1242/jcs.02670 . PMID 16306228 . S2CID 17404931 . Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY (July 2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats" . Journal of Virology . 80 (14): 7052–9. doi :10.1128/JVI.00103-06 . PMC 1489057 PMID 16809310 . Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, et al. (September 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells" . Proceedings of the National Academy of Sciences of the United States of America . 103 (39): 14379–84. Bibcode :2006PNAS..10314379W . doi :10.1073/pnas.0606714103 PMC 1569674 PMID 16980408 . Yang Q, Inoki K, Ikenoue T, Guan KL (October 2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity" . Genes & Development . 20 (20): 2820–32. doi :10.1101/gad.1461206 . PMC 1619946 PMID 17043309 . Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M (June 2007). "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression" . The EMBO Journal . 26 (12): 2880–9. doi :10.1038/sj.emboj.7601715 . PMC 1894761 PMID 17476304 . Kuraishy AI, French SW, Sherman M, Herling M, Jones D, Wall R, Teitell MA (June 2007). "TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation" . Proceedings of the National Academy of Sciences of the United States of America . 104 (24): 10175–80. Bibcode :2007PNAS..10410175K . doi :10.1073/pnas.0704170104 PMC 1891214 PMID 17548807 .
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction