Cannabaceae

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Bemesetron
Clinical data
ATC code
  • none
Identifiers
  • [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3,5-dichlorobenzoate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.164.757 Edit this at Wikidata
Chemical and physical data
FormulaC15H17Cl2NO2
Molar mass314.21 g·mol−1
3D model (JSmol)
  • CN3[C@@H]1CC[C@H]3C[C@H](C1)OC(=O)c2cc(Cl)cc(Cl)c2
  • InChI=1S/C15H17Cl2NO2/c1-18-12-2-3-13(18)8-14(7-12)20-15(19)9-4-10(16)6-11(17)5-9/h4-6,12-14H,2-3,7-8H2,1H3/t12-,13+,14+ checkY
  • Key:MNJNPLVXBISNSX-WDNDVIMCSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Bemesetron (MDL-72222) is a drug which acts as an antagonist at the 5HT3 receptor.[1] It has antiemetic effects comparable to metoclopramide,[2] however it is not used clinically, instead its main application is in scientific research studying the involvement of the 5HT3 receptor in the actions of drugs of abuse.[3][4][5][6]

See also[edit]

References[edit]

  1. ^ Shearman GT, Tolcsvai L (1987). "Effect of the selective 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 on 5-HTP-induced head shaking and behavioral symptoms induced by 5-methoxy-N,N,dimethyltryptamine in rats: comparison with some other 5-HT receptor antagonists". Psychopharmacology. 92 (4): 520–3. doi:10.1007/bf00176488. PMID 3114804. S2CID 25814825.
  2. ^ Homesley HD, Hahne WF, McLees B, et al. (April 1993). "Randomized comparison of the antiemetic efficacy of a serotonin type 3 receptor antagonist (MDL 72,222) with a high-dose metoclopramide regimen". Am. J. Clin. Oncol. 16 (2): 175–9. doi:10.1097/00000421-199304000-00020. PMID 8452114. S2CID 11733418.
  3. ^ McKinzie DL, McBride WJ, Murphy JM, Lumeng L, Li TK (October 2000). "Effects of MDL 72222, a serotonin3 antagonist, on operant responding for ethanol by alcohol-preferring P rats". Alcohol. Clin. Exp. Res. 24 (10): 1500–4. doi:10.1111/j.1530-0277.2000.tb04567.x. PMID 11045857.
  4. ^ Kankaanpää A, Meririnne E, Seppälä T (February 2002). "5-HT3 receptor antagonist MDL 72222 attenuates cocaine- and mazindol-, but not methylphenidate-induced neurochemical and behavioral effects in the rat". Psychopharmacology. 159 (4): 341–50. doi:10.1007/s00213-001-0939-4. PMID 11823886. S2CID 21614467.
  5. ^ Kos T, Popik P, Pietraszek M, et al. (May 2006). "Effect of 5-HT3 receptor antagonist MDL 72222 on behaviors induced by ketamine in rats and mice". Eur Neuropsychopharmacol. 16 (4): 297–310. doi:10.1016/j.euroneuro.2005.10.001. PMID 16288851. S2CID 43575963.
  6. ^ Yoo JH, Nam YS, Lee SY, Jang CG (January 2008). "Dopamine neurotransmission is involved in the attenuating effects of 5-HT3 receptor antagonist MDL 72222 on acute methamphetamine-induced locomotor hyperactivity in mice". Synapse. 62 (1): 8–13. doi:10.1002/syn.20461. PMID 17948891. S2CID 20699645.
source: https://en.wikipedia.org/wiki/Bemesetron

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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