Cannabaceae

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Anisodamine
Clinical data
Other names7β-hydroxyhyoscyamine
ATC code
  • None
Identifiers
  • [(1S,3S,5S,7S)-7-Hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenyl-propanoate
CAS Number
PubChem CID
ChemSpider
UNII
ECHA InfoCard100.164.962 Edit this at Wikidata
Chemical and physical data
FormulaC17H23NO4
Molar mass305.374 g·mol−1
3D model (JSmol)
  • O=C(O[C@@H]1C[C@@H]2N(C)[C@H](C1)C[C@@H]2O)[C@@H](c3ccccc3)CO
  • InChI=1S/C17H23NO4/c1-18-12-7-13(9-15(18)16(20)8-12)22-17(21)14(10-19)11-5-3-2-4-6-11/h2-6,12-16,19-20H,7-10H2,1H3/t12-,13+,14-,15+,16+/m1/s1 checkY
  • Key:WTQYWNWRJNXDEG-LEOABGAYSA-N checkY
  (verify)

Anisodamine, also known as 7β-hydroxyhyoscyamine, is an anticholinergic and α1 adrenergic receptor antagonist used in the treatment of acute circulatory shock in China.[1] It is given orally or by injection, as a racemic mixture (racanisodamine) or as a hydrobromide salt.[2] Eye drops at 0.5% concentration for slowing the progression of myopia is also available in China.[3]

Anisodamine is a naturally occurring tropane alkaloid found in some plants of the family Solanaceae including Datura.[4][5] Its Mandarin Chinese name 山莨菪碱 is given after Anisodus tanguticus (Chinese: 山莨菪; pinyin: shān làng dàng).[6]

See also[edit]

References[edit]

  1. ^ Varma DR, Yue TL (March 1986). "Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats". British Journal of Pharmacology. 87 (3): 587–94. doi:10.1111/j.1476-5381.1986.tb10201.x. PMC 1916562. PMID 2879586.
  2. ^ "Pharmacopoeia Search: "山莨菪碱"". 中国药典. Archived from the original on 2017-12-03.
  3. ^ "消旋山莨菪碱滴眼液防治少年儿童假性近视的疗效分析". 国际医药卫生导报 (in Chinese (China)). 14 (15): 67–68. 2008. doi:10.3760/cma.j.issn.1007-1245.2008.15.027.
  4. ^ Ye N, Li J, Gao C, Xie Y (August 2013). "Simultaneous determination of atropine, scopolamine, and anisodamine in Flos daturae by capillary electrophoresis using a capillary coated by graphene oxide". Journal of Separation Science. 36 (16): 2698–702. doi:10.1002/jssc.201300304. PMID 23868645.
  5. ^ Zhang WW, Song MK, Cui YY, et al. (October 2008). "Differential neuropsychopharmacological influences of naturally occurring tropane alkaloids anisodamine versus scopolamine". Neuroscience Letters. 443 (3): 241–5. doi:10.1016/j.neulet.2008.07.048. PMID 18672024. S2CID 2730169.
  6. ^ "消旋山莨菪碱" (in Chinese (China)). 中国药典. Archived from the original on 2017-12-03. Retrieved 3 December 2017.


source: https://en.wikipedia.org/wiki/Anisodamine

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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