Amidrine, Midrin, Nodolor, Duradrin, IDA, Migquin, Migrin-A, Migrazone or Epidrine is a combination drug consisting of paracetamol, dichloralphenazone and isometheptene used to treat migraines and severe, refractory headaches.[1]
Components[edit]
- Paracetamol, also known as acetaminophen, is a common over-the-counter pain reliever and fever reducer.
- Dichloralphenazone is a prodrug of two pharmacologically distinct agents: the sedative agent, chloral hydrate, as well as antipyrine, a non-steroidal anti-inflammatory drug that works to decrease inflammation.
- Isometheptene is a sympathomimetic drug that works by inducing vasoconstriction, causing constriction of cerebral blood vessels and reducing migraine symptoms.
Availability[edit]
Midrin was discontinued by Caraco Pharmaceuticals as of 2009, after an FDA seizure of 33 drugs manufactured by Caraco Pharmaceuticals due to cGMP (Current Good Manufacturing Practices) violations.[2] Generic forms of Amidrine were also discontinued due to loss of FDA grandfather approval status. Thus, manufacturer interest faded. The discontinued generic forms are: Amidrine (Actavis), Duradrin (Barr), I.D.A (Teva), Migquin (Qualitest), Migrin-A (Prasco) and Migrazone (Breckenridge).[3] However, it is now being manufactured by Macoven Pharmaceuticals and marketed under the name Nodolor, as of April 2014. It can also be obtained through a compounding pharmacy with a doctor's prescription.
References[edit]
- ^ Freitag, Frederick G.; Cady, Roger; DiSerio, Frank (20 Dec 2001). "Comparative Study of a Combination of Isometheptene Mucate, Dichloralphenazone With Acetaminophen and Sumatriptan Succinate in the Treatment of Migraine". Headache. 41 (4): 391–8. doi:10.1046/j.1526-4610.2001.111006391.x. PMID 11318886. S2CID 35970757.
- ^ "Questions and Answers: Seizure of Drug Products Manufactured by Caraco Pharmaceutical Laboratories Ltd". Food and Drug Administration.
- ^ "Drug Profiles: MIDRIN®".
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