Cannabaceae

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ACP-105
Legal status
Legal status
Identifiers
  • 2-chloro-4-(3-hydroxy-3-methyl-8-azabicyclo[3.2.1]octan-8-yl)-3-methylbenzonitrile
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H19ClN2O
Molar mass290.79 g·mol−1
3D model (JSmol)
  • CC1=C(C=CC(=C1Cl)C#N)N2C3CCC2CC(C3)(C)O
  • InChI=1S/C16H19ClN2O/c1-10-14(6-3-11(9-18)15(10)17)19-12-4-5-13(19)8-16(2,20)7-12/h3,6,12-13,20H,4-5,7-8H2,1-2H3
  • Key:OUEODVPKPRQETQ-UHFFFAOYSA-N

ACP-105 is a drug which acts as a selective androgen receptor modulator (SARM). It has been investigated for potential use in the treatment of age-related cognitive decline.[1][2][3][4] The drug has been found to reduce anxiety-like behavior in a mouse model of Alzheimer's disease when administered alone, as well as enhance spatial memory when coadministered with the selective estrogen receptor β agonist AC-186.[3] ACP-105 is an aniline SARM and is related to AC-262536 and vosilasarm (RAD140).[5]

References[edit]

  1. ^ Schlienger N, Lund BW, Pawlas J, Badalassi F, Bertozzi F, Lewinsky R, et al. (November 2009). "Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators". Journal of Medicinal Chemistry. 52 (22): 7186–7191. doi:10.1021/jm901149c. PMID 19856921.
  2. ^ Dayger C, Villasana L, Pfankuch T, Davis M, Raber J (March 2011). "Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice". Brain Research. 1381: 134–140. doi:10.1016/j.brainres.2010.12.088. PMC 3048897. PMID 21219889.
  3. ^ a b George S, Petit GH, Gouras GK, Brundin P, Olsson R (December 2013). "Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease". ACS Chemical Neuroscience. 4 (12): 1537–1548. doi:10.1021/cn400133s. PMC 3867967. PMID 24020966.
  4. ^ Cutler C, Viljanto M, Taylor P, Hincks P, Biddle S, Van Eenoo P (October 2021). "Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes". Drug Testing and Analysis. 14 (2): 349–370. doi:10.1002/dta.3189. hdl:1854/LU-8740373. PMID 34714606. S2CID 240152623.
  5. ^ Zhang X, Sui Z (February 2013). "Deciphering the selective androgen receptor modulators paradigm". Expert Opinion on Drug Discovery. 8 (2): 191–218. doi:10.1517/17460441.2013.741582. PMID 23231475. S2CID 2584722.


source: https://en.wikipedia.org/wiki/ACP-105

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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