Cannabaceae

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77-LH-28-1
Identifiers
  • 1-[3-(4-butylpiperidin-1-yl)propyl]-3,4-dihydroquinolin-2-one
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H32N2O
Molar mass328.500 g·mol−1
3D model (JSmol)
  • O=C2N(c1ccccc1CC2)CCCN3CCC(CC3)CCCC
  • InChI=1S/C21H32N2O/c1-2-3-7-18-12-16-22(17-13-18)14-6-15-23-20-9-5-4-8-19(20)10-11-21(23)24/h4-5,8-9,18H,2-3,6-7,10-17H2,1H3
  • Key:PHMGZAICAOYEAF-UHFFFAOYSA-N

77-LH-28-1 is a selective agonist of muscarinic acetylcholine receptor subtype 1 (M1) discovered in 2008. It is an allosteric agonist, exhibiting over 100-fold specificity for M1 over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the blood–brain barrier and is therefore a useful pharmacological tool with cognition enhancing effects.[1]

References[edit]

  1. ^ Langmead CJ, Austin NE, Branch CL, Brown JT, Buchanan KA, Davies CH, et al. (July 2008). "Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1". British Journal of Pharmacology. 154 (5): 1104–1115. doi:10.1038/bjp.2008.152. PMC 2451039. PMID 18454168.
source: https://en.wikipedia.org/wiki/77-LH-28-1

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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