Cannabaceae

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5-Fluoro-DET
Clinical data
Other names
  • 5-F-DET
  • 5-Fluoro-N,N-diethyltryptamine
Identifiers
  • N,N-diethyl-2-(5-fluoro-1H-indol-3-yl)ethanamine
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC14H19FN2
Molar mass234.318 g·mol−1
3D model (JSmol)
  • CCN(CC)CCC1=CNC2=C1C=C(C=C2)F
  • InChI=1S/C14H19FN2/c1-3-17(4-2)8-7-11-10-16-14-6-5-12(15)9-13(11)14/h5-6,9-10,16H,3-4,7-8H2,1-2H3
  • Key:LBJIPBJDJFZKIQ-UHFFFAOYSA-N

5-Fluoro-DET (5F-DET, 5-fluoro-N,N-diethyltryptamine) is a tryptamine derivative related to drugs such as DET and 5-MeO-DET.[1][2] It acts as an inhibitor of the enzyme myeloperoxidase,[3] and is also thought to be an agonist at the 5-HT2A receptor.[4]

See also[edit]

References[edit]

  1. ^ Pelchowicz Z, Kaluszyner A, Bentov M (1961). "1067. N-alkylated 5-fluorotryptamines". Journal of the Chemical Society (Resumed): 5418–5421. doi:10.1039/JR9610005418.
  2. ^ Kalir A, Szara S (May 1966). "Synthesis and pharmacological activity of alkylated tryptamines". Journal of Medicinal Chemistry. 9 (3): 341–4. doi:10.1021/jm00321a017. PMID 5960901.
  3. ^ Soubhye J, Prévost M, Van Antwerpen P, Zouaoui Boudjeltia K, Rousseau A, Furtmüller PG, Obinger C, Vanhaeverbeek M, Ducobu J, Néve J, Gelbcke M, Dufrasne FO (December 2010). "Structure-based design, synthesis, and pharmacological evaluation of 3-(aminoalkyl)-5-fluoroindoles as myeloperoxidase inhibitors" (PDF). Journal of Medicinal Chemistry. 53 (24): 8747–59. doi:10.1021/jm1009988. PMID 21090682. S2CID 207225972.
  4. ^ WO 2021/168082, Kruegel AC, Sporn J, "Specific Tryptamines for use in the Treatment of Mood Disorders.", published 26 August 2021, assigned to Gilgamesh Pharmaceuticals, Inc.. 
source: https://en.wikipedia.org/wiki/5-Fluoro-DET

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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