Clinical data | |
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Trade names | Fasigyn, Simplotan, Tindamax |
AHFS/Drugs.com | Monograph |
MedlinePlus | a604036 |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Protein binding | 12% |
Metabolism | Liver (CYP3A4) |
Elimination half-life | 12–14 hours |
Excretion | Urine (20–25%), feces (12%) |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.039.089 |
Chemical and physical data | |
Formula | C8H13N3O4S |
Molar mass | 247.27 g·mol−1 |
3D model (JSmol) | |
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Tinidazole, sold under the brand name Tindamax among others, is a medication used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of anaerobic amoebic and bacterial infections. It was developed in 1972 and is a prominent member of the nitroimidazole antibiotic class.[2]
It is on the World Health Organization's List of Essential Medicines.[3]
Medical uses
[edit]Tinidazole may be a therapeutic alternative in the setting of metronidazole intolerance. Tinidazole is used to treat Helicobacter pylori, Amoebic dysentery, Giardia and Trichomonas vaginalis.[4]
Side effects
[edit]Drinking alcohol while taking tinidazole causes an unpleasant disulfiram-like reaction, which includes nausea, vomiting, headache, increased blood pressure, flushing, and shortness of breath.[medical citation needed]
Half-life
[edit]Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours.[medical citation needed]
References
[edit]- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
- ^ Ebel K, Koehler H, Gamer AO, Jäckh R (2002). "Imidazole and Derivatives.". In Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH. doi:10.1002/14356007.a13_661. ISBN 3527306730.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- ^ Edwards DI (January 1993). "Nitroimidazole drugs--action and resistance mechanisms. I. Mechanisms of action". The Journal of Antimicrobial Chemotherapy. 31 (1): 9–20. doi:10.1093/jac/31.1.9. PMID 8444678.
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction