Cannabaceae

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PD-137889
Names
IUPAC name
(4aR)-N-Methyl-1,2,3,4,9,9a-hexahydro-4aH-fluoren-4a-amine
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C14H19N/c1-15-14-9-5-4-7-12(14)10-11-6-2-3-8-13(11)14/h2-3,6,8,12,15H,4-5,7,9-10H2,1H3
    Key: KQLIVVYSTDBTMZ-UHFFFAOYSA-N
  • c12c(cccc1)C3(NC)CCCCC3C2
Properties
C14H19N
Molar mass 201.313 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

PD-137889 (N-methylhexahydrofluorenamine) is a chemical compound that is active as an NMDA receptor antagonist in the central nervous system at roughly 30 times the potency of the "flagship" of its class, ketamine,[1] and substitutes for phencyclidine in animal studies.[2][3][4] Ki [3H]TCP[a] binding = 27 nM versus ketamine's Ki = 860 nM.[5]


See also[edit]

References[edit]

  1. ^ Hays, Sheryl J.; Novak, Perry M.; Ortwine, Daniel F.; Bigge, Christopher F.; Colbry, Norman L.; Johnson, Graham; Lescosky, Leonard J.; Malone, Thomas C.; Michael, Andre (1993). "Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor". J Med Chem. 36 (6): 654–70. doi:10.1021/jm00058a002. PMID 8459395.
  2. ^ Nicholson, Katherine L.; Balster, Robert L. (2003). "Evaluation of the phencyclidine-like discriminative stimulus effects of novel NMDA channel blockers in rats". Psychopharmacology. 170 (2): 215–224. doi:10.1007/s00213-003-1527-6. PMID 2851738. S2CID 30803162.
  3. ^ Bigge, Christopher F. (1993). "Structural requirements for the development of potent n-methyl-d-aspartic acid (NMDA) receptor antagonists". Biochemical Pharmacology. 45 (8): 1547–1561. doi:10.1016/0006-2952(93)90294-7. PMID 7683469.
  4. ^ Bigge, Christopher F.; Malone, Thomas C. (1993). "Overview: Agonists, Antagonists and Modulators of the N-methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) Subtypes of Glutamate Receptors". Current Opinion on Therapeutic Patents. 3 (7): 951–989. doi:10.1517/13543776.3.7.951.
  5. ^ Polycyclic amine derivatives useful as cerebrovascular agents Archived 2018-02-03 at the Wayback Machine United States Patent; Coughenour, et al. Family ID: 22686445 Appl. #07/186,834
  1. ^ [3H]N-[1-(2-thienyl)cyclohex-yl]piperidine


source: Https://en.wikipedia.org/wiki/PD-137889

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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