Cannabaceae

PBX2
Identifiers
AliasesPBX2, G17, HOX12, PBX2MHC, PBX homeobox 2
External IDsOMIM: 176311; MGI: 1341793; HomoloGene: 48115; GeneCards: PBX2; OMA:PBX2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002586

NM_017463

RefSeq (protein)

NP_002577

NP_059491

Location (UCSC)Chr 6: 32.18 – 32.19 MbChr 17: 34.81 – 34.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.[5][6]

Function

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This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.[6]

Interactions

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PBX2 has been shown to interact with HOXA9.[7]

References

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  1. ^ a b c ENSG00000237344, ENSG00000236353, ENSG00000232005, ENSG00000225987, ENSG00000206315, ENSG00000204304 GRCh38: Ensembl release 89: ENSG00000224952, ENSG00000237344, ENSG00000236353, ENSG00000232005, ENSG00000225987, ENSG00000206315, ENSG00000204304Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034673Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (Sep 1994). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics. 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890.
  6. ^ a b "Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2".
  7. ^ Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology. 19 (4): 3051–61. doi:10.1128/mcb.19.4.3051. PMC 84099. PMID 10082572.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

One thought on “Cannabaceae

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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