Cannabaceae

thcscience_admin
MS-245
Clinical data
ATC code
  • none
Identifiers
  • 2-[5-methoxy-1-(phenylsulfonyl)-1H-indol-3-yl]-N,N-dimethylethanamine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H22N2O3S
Molar mass358.46 g·mol−1
3D model (JSmol)
  • COc2cc1c(CCN(C)C)cn(c1cc2)S(=O)(=O)c3ccccc3
  • InChI=1S/C19H22N2O3S/c1-20(2)12-11-15-14-21(19-10-9-16(24-3)13-18(15)19)25(22,23)17-7-5-4-6-8-17/h4-10,13-14H,11-12H2,1-3H3
  • Key:AIJIQCBYMBZLJD-UHFFFAOYSA-N
  (verify)

MS-245 is a tryptamine derivative used in scientific research. It acts as a selective 5-HT6 receptor antagonist with a Ki of 2.3 nM, and was derived through structure-activity relationship development of the selective 5-HT6 agonist EMDT.[1] It has been used as a lead compound for further development of tryptamine-derived 5-HT6 antagonists.[2][3] In animal studies it has been shown to boost the activity of, but not substitute for, both amphetamine and nicotine.[4][5]

See also[edit]

References[edit]

  1. ^ Tsai Y, Dukat M, Slassi A, MacLean N, Demchyshyn L, Savage JE, et al. (October 2000). "N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists". Bioorganic & Medicinal Chemistry Letters. 10 (20): 2295–9. doi:10.1016/S0960-894X(00)00453-4. PMID 11055342.
  2. ^ Abate C, Kolanos R, Dukat M, Setola V, Roth BL, Glennon RA (August 2005). "Interaction of chiral MS-245 analogs at h5-HT6 receptors". Bioorganic & Medicinal Chemistry Letters. 15 (15): 3510–3. doi:10.1016/j.bmcl.2005.05.092. PMID 15990303.
  3. ^ Dukat M, Mosier PD, Kolanos R, Roth BL, Glennon RA (February 2008). "Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies". Journal of Medicinal Chemistry. 51 (3): 603–11. doi:10.1021/jm070910s. PMC 5994921. PMID 18201064.
  4. ^ Pullagurla M, Bondareva T, Young R, Glennon RA (June 2004). "Modulation of the stimulus effects of (+)amphetamine by the 5-HT6 antagonist MS-245". Pharmacology, Biochemistry, and Behavior. 78 (2): 263–8. doi:10.1016/j.pbb.2004.03.017. PMID 15219766. S2CID 25350474.
  5. ^ Young R, Bondareva T, Wesolowska A, Young S, Glennon RA (September 2006). "Effect of the 5-HT(6) serotonin antagonist MS-245 on the actions of (-)nicotine". Pharmacology, Biochemistry, and Behavior. 85 (1): 170–7. doi:10.1016/j.pbb.2006.07.029. PMID 16950502. S2CID 38662192.
source: Https://en.wikipedia.org/wiki/MS-245

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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