The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Guipponi M, Scott HS, Chen H, Schebesta A, Rossier C, Antonarakis SE (Nov 1998). "Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon". Genomics. 53 (3): 369–76. doi:10.1006/geno.1998.5521. PMID9799604.
Keating DJ, Chen C, Pritchard MA (Nov 2006). "Alzheimer's disease and endocytic dysfunction: clues from the Down syndrome-related proteins, DSCR1 and ITSN1". Ageing Research Reviews. 5 (4): 388–401. doi:10.1016/j.arr.2005.11.001. PMID16442855. S2CID12867672.
Chen H, Antonarakis SE (1998). "The SH3D1A gene maps to human chromosome 21q22.1-->q22.2". Cytogenetics and Cell Genetics. 78 (3–4): 213–5. doi:10.1159/000134659. PMID9465890.
Sparks AB, Hoffman NG, McConnell SJ, Fowlkes DM, Kay BK (Jun 1996). "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins". Nature Biotechnology. 14 (6): 741–4. doi:10.1038/nbt0696-741. PMID9630982. S2CID11166026.
Guipponi M, Scott HS, Hattori M, Ishii K, Sakaki Y, Antonarakis SE (1999). "Genomic structure, sequence, and refined mapping of the human intersectin gene (ITSN), which encompasses 250 kb on chromosome 21q22.1-->q22.2". Cytogenetics and Cell Genetics. 83 (3–4): 218–20. doi:10.1159/000015182. PMID10072581. S2CID27453719.
Pucharcos C, Estivill X, de la Luna S (Jul 2000). "Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis". FEBS Letters. 478 (1–2): 43–51. doi:10.1016/S0014-5793(00)01793-2. PMID10922467. S2CID24683452.
Hussain NK, Jenna S, Glogauer M, Quinn CC, Wasiak S, Guipponi M, Antonarakis SE, Kay BK, Stossel TP, Lamarche-Vane N, McPherson PS (Oct 2001). "Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP". Nature Cell Biology. 3 (10): 927–32. doi:10.1038/ncb1001-927. PMID11584276. S2CID22914248.
Pucharcos C, Casas C, Nadal M, Estivill X, de la Luna S (Oct 2001). "The human intersectin genes and their spliced variants are differentially expressed". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1521 (1–3): 1–11. doi:10.1016/s0167-4781(01)00276-7. PMID11690630.
Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10.1038/nsb796. PMID12006984. S2CID13161854.
Irie F, Yamaguchi Y (Nov 2002). "EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP". Nature Neuroscience. 5 (11): 1117–8. doi:10.1038/nn964. PMID12389031. S2CID130279.
PDB gallery
1ki1: Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42
One thought on “Cannabaceae”
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction
Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction