Cannabaceae

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CP-93129
Identifiers
  • 3-(1,2,3,6-tetrahydropyridin-4-yl)-1,4-dihydropyrrolo[3,2-b]pyridin-5-one
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H13N3O
Molar mass215.256 g·mol−1
3D model (JSmol)
  • C3CNCC=C3c(c1n2)cnc1ccc2=O

CP-93129 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 150x and 200x selectivity over the closely related 5-HT1D and 5-HT1A receptors.[1] It is used in the study of 5-HT1B receptors in the brain, particularly their role in modulating the release of other neurotransmitters.[2][3][4][5]

References[edit]

  1. ^ Macor JE, Burkhart CA, Heym JH, Ives JL, Lebel LA, Newman ME, et al. (August 1990). "3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole". Journal of Medicinal Chemistry. 33 (8): 2087–93. doi:10.1021/jm00170a007. PMID 2374139.
  2. ^ De Groote L, Olivier B, Westenberg HG (August 2003). "Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice". European Journal of Pharmacology. 476 (1–2): 71–7. doi:10.1016/s0014-2999(03)02154-x. PMID 12969751.
  3. ^ Przegaliński E, Papla I, Siwanowicz J, Filip M (May 2004). "Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats". European Neuropsychopharmacology. 14 (3): 217–25. doi:10.1016/S0924-977X(03)00106-8. PMID 15056481. S2CID 308992.
  4. ^ Bramley JR, Sollars PJ, Pickard GE, Dudek FE (June 2005). "5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus". Journal of Neurophysiology. 93 (6): 3157–64. CiteSeerX 10.1.1.325.6052. doi:10.1152/jn.00770.2004. PMID 15716370.
  5. ^ Saitow F, Murano M, Suzuki H (March 2009). "Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei". Journal of Neurophysiology. 101 (3): 1361–74. doi:10.1152/jn.90750.2008. PMID 19144744.
source: Https://en.wikipedia.org/wiki/CP-93129

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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