Cannabaceae

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AS-19
Identifiers
  • (2S)-N,N-dimethyl-5-(1,3,5-trimethylpyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC18H25N3
Molar mass283.419 g·mol−1
3D model (JSmol)
  • CC1=C(C(=NN1C)C)C2=C3CC[C@@H](CC3=CC=C2)N(C)C
  • InChI=1S/C18H25N3/c1-12-18(13(2)21(5)19-12)17-8-6-7-14-11-15(20(3)4)9-10-16(14)17/h6-8,15H,9-11H2,1-5H3/t15-/m0/s1 checkY
  • Key:BTTOYOKCLDAHHO-HNNXBMFYSA-N checkY
  (verify)

AS-19 is a substance which acts as a potent agonist at the 5-HT7 receptor, with an IC50 of 0.83 nM. It reverses the amnesia induced by drugs such as scopolamine and dizocilpine and improves long-term memory acquisition, but inhibits short-term memory formation.[1][2]

See also

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References

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  1. ^ Meneses A, Perez-Garcia G, Liy-Salmeron G, Flores-Galvez D, Castillo C, Castillo E (December 2008). "The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation". Behavioural Brain Research. 195 (1): 112–9. doi:10.1016/j.bbr.2007.11.023. PMID 18191236. S2CID 144901859.
  2. ^ Perez-García G, Meneses A (December 2008). "Ex vivo study of 5-HT(1A) and 5-HT(7) receptor agonists and antagonists on cAMP accumulation during memory formation and amnesia". Behavioural Brain Research. 195 (1): 139–46. doi:10.1016/j.bbr.2008.07.033. PMID 18723050. S2CID 140204255.
source: Https://en.wikipedia.org/wiki/AS-19_(drug)

One thought on “Cannabaceae”

  1. Well, that’s interesting to know that Psilotum nudum are known as whisk ferns. Psilotum nudum is the commoner species of the two. While the P. flaccidum is a rare species and is found in the tropical islands. Both the species are usually epiphytic in habit and grow upon tree ferns. These species may also be terrestrial and grow in humus or in the crevices of the rocks.
    View the detailed Guide of Psilotum nudum: Detailed Study Of Psilotum Nudum (Whisk Fern), Classification, Anatomy, Reproduction

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