A relapse is a recurrence of a past (typically medical) condition. It may also refer to:
- Relapse Records, a record label
- Relapse (Eminem album), a 2009 album by Eminem
- Relapse (Ministry album), a 2012 music album by Ministry
- Relapse (EP), a 2002 EP by Oceansize
- The Relapse, a 1696 play by John Vanbrugh