Löfgren or Lofgren is a Swedish surname. Notable people with the surname include:

• Anna-Lena Löfgren (1944–2010), Swedish singer
• Charles Löfgren, chairman of Västmanland-Nerikes BK
• Eliel Löfgren (1872–1940), Swedish jurist and politician
• Johan Albert Constantin Löfgren (1854–1918), botanist at the Rio de Janeiro Botanical Garden
• Gösta Löfgren (1891–1932), Finnish footballer
• Gösta Löfgren (1923–2006), Swedish footballer
• Jonna Löfgren, drummer of the Scottish band Glasvegas
• Katia Löfgren, singer of the Swedish band Caramell
• Marianne Löfgren (1910–1957), Swedish actress
• Mikael Löfgren (born 1969), Swedish biathlete
• Nils Löfgren (1913–1967), Swedish chemist
• Sara Löfgren (born 1977), Swedish singer
• Stig Löfgren (1912–1998), Swedish Army lieutenant general
• Tomas Löfgren, Swedish ski-orienteering competitor and world champion
• Ulla Löfgren (born 1943), Swedish politician of the Moderate Party

• Edward J. Lofgren (1914–2016), American physicist
• Esther Lofgren (born 1985), American rower
• Karen Lofgren (born 1976), Canadian artist
• Mark Lofgren (born 1961), American politician
• Mike Lofgren, American politician
• Nils Lofgren (born 1951), American musician
• William Lofgren (1913–2004), American canoer
• William Lofgren, American tennis player
• Zoe Lofgren (born 1947), American politician

• Lofgren Peninsula - ice-covered peninsula, Antarctica
• Löfgren syndrome - type of acute sarcoidosis
• Nils (album) - 1979 record album by Nils Lofgren
• Nils Lofgren (album) - 1975 record album by Nils Lofgren
• 7157 Lofgren - Main-belt Asteroid discovered by S. J. Bus at Siding Spring Observatory