Protein-coding gene in the species Homo sapiens
Kininogen-1 (KNG1), also known as alpha-2-thiol proteinase inhibitor , Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor is a protein [ 5] that in humans is encoded by the KNG1 gene .[ 6] [ 7] Kininogen-1 is the precursor protein to high-molecular-weight kininogen (HMWK), low-molecular-weight kininogen (LMWK), and bradykinin .[ 5]
The KNG1 gene uses alternative splicing to generate two different proteins: high-molecular-weight kininogen (HMWK) and low-molecular-weight kininogen (LMWK). HMWK in turn is cleaved by the enzyme kallikrein to produce bradykinin .
HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin , a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation.[ 6]
Kininogen-1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system .
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