Issac may refer to:

• Issac Bailey, American writer
• Issac Blakeney (born 1992), American football wide receiver
• Issac Booth (born 1971), American football player
• Issac Ryan Brown (born 2005), American child actor and singer
• Issac Delgado (born 1962), Cuban-Spanish musician, and salsa performer
• Issac Honey (born 1993), Ghanaian footballer
• Issac Koga (1899–1982), Japanese electronics researcher/engineer
• Issac Luke (born 1987), New Zealand rugby league hooker
• Issac Osae (born 1993), Ghanaian footballer

• Osthatheos Issac (born 1976), Syriac Orthodox bishop
• Rod Issac (born 1989), American football cornerback

• Issac, Dordogne, a commune in France.

• Isaac (name)
• Isaac (disambiguation)