Higuchi (樋口, literally "mouth of the drain") is a common Japanese surname.

• Akihiro Higuchi, Ukrainian-born film director known by his alias Higuchinsky
• Asa Higuchi (ひぐち アサ, born 1970), Japanese manga artist
• Chieko Higuchi (樋口 智恵子, born 1981), Japanese voice actress
• Daisuke Higuchi (樋口 大輔, born 1966), Japanese manga artist
• Dean Higuchi, American professional wrestler better known as Dean Ho
• Hisako Higuchi (樋口 久子, born 1945), Japanese golfer
• Ichiyō Higuchi (樋口 一葉, 1872 – 1896), Japanese Meiji-era author
• Kanako Higuchi (樋口 可南子, born 1958), Japanese actress
• Kanetsugu Higuchi (樋口 兼続, 1559–1620), Japanese samurai better known as Naoe Kanetsugu
• Kazusada Higuchi (樋口 和貞, born 1988), Japanese professional wrestler
• Keiko Higuchi (樋口 恵子, born 1932), Japanese journalist
• Keiko Sofía Fujimori Higuchi (born 1975), Peruvian politician, daughter of Alberto Fujimori and Susana Higuchi
• Kenji Higuchi (樋口 健二, born 1937), Japanese photographer
• Kiichiro Higuchi (樋口 季一郎, 1888–1970), Imperial Army lieutenant-general
• Kozo Higuchi (樋口 浩三, born 1956), Japanese swimmer
• Motoya Higuchi, Japanese race-car driver
• Munetaka Higuchi (樋口 宗孝, 1958 – 2008), Japanese drummer for the band Loudness
• Naomi Higuchi (樋口 直巳, born 1961), Japanese sport wrestler
• Shinji Higuchi (樋口 真嗣, born 1965), Japanese storyboard artist
• Sojiro Higuchi (樋口 壮士朗, born 1992), Japanese professional wrestler better known as Jiro Kuroshio
• Susana Higuchi, Peruvian politician, wife of Alberto Fujimori and mother of Keiko Sofía Fujimori Higuchi
• Tachibana Higuchi (樋口 橘, born 1976), Japanese manga artist
• Tadao Higuchi (樋口 忠男, 1916 - 1992), Japanese photographer
• Tokihiko Higuchi (樋口 時彦, born 1941), Japanese volleyball player
• Tomoyuki Higuchi (樋口 知行, born 1985), Japanese footballer
• Yasuhiro Higuchi (樋口 靖洋, born 1961), Japanese football player
• Wakaba Higuchi (樋口新葉, born 2001), Japanese figure skater
• William Higuchi (樋口 宇生利明夢), American chemist and professor
• Yuta Higuchi (樋口 雄太, born 1996), Japanese footballer
• Yutaka Higuchi (figure skater) (樋口 豊, born 1949), Japanese figure skater
• Yutaka Higuchi (bassist) (桶口 豊, born 1967), Japanese bassist for the band Buck-Tick

• Kotaro Higuchi (樋口 湖太郎), Pita-Ten character
• Kyosuke Higuchi (火口 卿介), Death Note character

• Higuchi Station (Ibaraki)
• Higuchi Station (Saitama)