Flight 405 may refer to:

• Mohawk Airlines Flight 405 (1972), crashed on final approach to Albany International Airport, killing 17
• Finnair Flight 405 (1978), hijacked, all survived
• Indian Airlines Flight 405, hijacked, all survived
• USAir Flight 405 (1992), crashed shortly after liftoff from New York City LaGuardia airport, killing 27
• Dynamic Airways Flight 405 (2015), caught fire but all survived