Human protein
CD6 (C luster of D ifferentiation 6) is a human protein encoded by the CD6 gene .[ 5] [ 6]
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule . The gene product is important for continuation of T cell activation .[ 5]
Clinical significance [ edit ]
Certain alleles of this gene may be associated with susceptibility to multiple sclerosis .[ 7] [ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000013725 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024670 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ a b "Entrez Gene: CD6 CD6 molecule" .
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^ De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR (2009). "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci" . Nat. Genet . 41 (7): 776–82. doi :10.1038/ng.401 . PMC 2757648 . PMID 19525953 .
^ Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA (2011). "The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation" . J. Immunol . 187 (6): 3286–91. doi :10.4049/jimmunol.1100626 . PMID 21849685 .
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Kobarg J, Whitney GS, Palmer D, Aruffo A, Bowen MA (1998). "Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains". Eur. J. Immunol . 27 (11): 2971–80. doi :10.1002/eji.1830271133 . PMID 9394826 . S2CID 20897222 .
Singer NG, Mitra R, Lialios F, Richardson BC, Marks RM, Pesando JM, Fox DA, Nickoloff BJ (1998). "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes". Immunol. Lett . 58 (1): 9–14. doi :10.1016/S0165-2478(97)02707-7 . PMID 9436462 .
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Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function" . J. Biol. Chem . 278 (9): 7607–16. doi :10.1074/jbc.M210455200 . PMID 12493773 .
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Kato Y, Tanaka Y, Hayashi M, Okawa K, Minato N (2006). "Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens" . J. Immunol . 177 (2): 877–84. doi :10.4049/jimmunol.177.2.877 . PMID 16818742 .
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Hassan NJ, Simmonds SJ, Clarkson NG, Hanrahan S, Puklavec MJ, Bomb M, Barclay AN, Brown MH (2006). "CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76" . Mol. Cell. Biol . 26 (17): 6727–38. doi :10.1128/MCB.00688-06 . PMC 1592849 . PMID 16914752 .
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .