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Formula | C20H21F3N2O2 |
Molar mass | 378.395 g·mol−1 |
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Tilapertin (INN), also known as AMG-747,[1] is a investigational drug which was being evaluated as an antipsychotic.[2]
Mechanism of action
[edit]Tilapertin appears to act via the blocking of the type 1 Glycine transporter,[3] making it a Glycine re-uptake inhibitor.
History
[edit]Two studies have been made in order to determine the safety of AMG-747 and its potential as an add-on to anti-psychotic therapy in people with schizophrenia. These studies were later halted due to a case of Stevens–Johnson syndrome in one of the participants.[3]
See also
[edit]References
[edit]- ^ "Tilapertin". PubChem. U.S. National Library of Medicine. Retrieved 2024-08-16.
- ^ World Health Organization (2013). "International Nonproprietary Names for Pharmaceutical Substances (INN): Proposed INN: List 110" (PDF). WHO Drug Information. 27 (4). World Health Organization.
- ^ a b Dunayevich E, Buchanan RW, Chen CY, Yang J, Nilsen J, Dietrich JM, et al. (April 2017). "Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia". Schizophrenia Research. 182: 90–97. doi:10.1016/j.schres.2016.10.027. PMID 27789188.