10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1gene.[5]
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.[5]
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Krupenko SA, Oleinik NV (2002). "10-formyltetrahydrofolate dehydrogenase, one of the major folate enzymes, is down-regulated in tumor tissues and possesses suppressor effects on cancer cells". Cell Growth Differ. 13 (5): 227–36. PMID12065246.
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PDB gallery
1s3i: Crystal structure of the N terminal hydrolase domain of 10-formyltetrahydrofolate dehydrogenase
2bw0: CRYSTAL STRUCTURE OF THE HYDROLASE DOMAIN OF HUMAN 10-FORMYLTETRAHYDROFOLATE 2 DEHYDROGENASE
2cfi: THE HYDROLASE DOMAIN OF HUMAN 10-FTHFD IN COMPLEX WITH 6-FORMYLTETRAHYDROPTERIN
2cq8: Solution structure of RSGI RUH-033, a pp-binding domain of 10-FTHFDH from human cDNA
2o2p: Crystal structure of the C-terminal domain of rat 10'formyltetrahydrofolate dehydrogenase
2o2q: Crystal structure of the C-terminal domain of rat 10'formyltetrahydrofolate dehydrogenase in complex with NADP
2o2r: Crystal structure of the C-terminal domain of rat 10'formyltetrahydrofolate dehydrogenase in complex with NADPH