Mirzoyan (Armenian: Միրզոյան), is an Armenian surname. Notable people with the surname include:

• Alexander Mirzayan (born 1945), Russian singer-songwriter
• Alexander Mirzoyan (born 1951), Soviet association football player
• Arakel Mirzoyan (born 1989), Armenian weightlifter
• Ararat Mirzoyan (born 1979), Armenian politician and Armenian First Deputy Prime Minister since May 2018
• Arayik Mirzoyan (born 1987), Armenian weightlifter
• Arsen Mirzoyan (born 1978), Ukrainian singer
• Edvard Mirzoyan (1921–2012), Armenian composer
• Karen Mirzoyan, Former Minister of Foreign Affairs (2012–2017) of the Artsakh Republic
• Levon Mirzoyan (1897–1939), Soviet statesman
• Oksen Mirzoyan (born 1961), Soviet weightlifter
• Pharaon Mirzoyan (born 1949), Armenian painter

• Mirzoyan–Terdjanian organization, an Armenian-American organized crime group, mastermind of the 2010 Medicaid fraud in the United States