Tuning P450 enzymes as oxidation catalysts R Fasan ACS Catalysis 2 (4), 647-666, 2012 | 293 | 2012 |
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties R Fasan, MM Chen, NC Crook, FH Arnold Angewandte Chemie International Edition 46 (44), 8414-8418, 2007 | 278 | 2007 |
Molecular basis of RNA recognition by the human alternative splicing factor Fox‐1 SD Auweter, R Fasan, L Reymond, JG Underwood, DL Black, S Pitsch, ... The EMBO journal 25 (1), 163-173, 2006 | 241 | 2006 |
Evolutionary history of a specialized p450 propane monooxygenase R Fasan, YT Meharenna, CD Snow, TL Poulos, FH Arnold Journal of molecular biology 383 (5), 1069-1080, 2008 | 223 | 2008 |
Using a β‐hairpin to mimic an α‐helix: cyclic peptidomimetic inhibitors of the p53–HDM2 protein–protein interaction R Fasan, RLA Dias, K Moehle, O Zerbe, JW Vrijbloed, D Obrecht, ... Angewandte Chemie International Edition 43 (16), 2109-2112, 2004 | 218 | 2004 |
Highly diastereoselective and enantioselective olefin cyclopropanation using engineered myoglobin‐based catalysts M Bordeaux, V Tyagi, R Fasan Angewandte Chemie 127 (6), 1764-1768, 2015 | 213 | 2015 |
Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions OF Brandenberg, R Fasan, FH Arnold Current opinion in biotechnology 47, 102-111, 2017 | 196 | 2017 |
Structure-Activity Studies in a Family of b-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction R Fasan, RLA Dias, K Moehle, O Zerbe, D Obrecht, PRE Mittl, MG Grutter, ... ChemBioChem 7 (3), 515-526, 2006 | 162 | 2006 |
Controlled Oxidation of Remote sp3 C–H Bonds in Artemisinin via P450 Catalysts with Fine-Tuned Regio- and Stereoselectivity K Zhang, BM Shafer, MD Demars, HA Stern, R Fasan Journal of the American Chemical Society 134 (45), 18695-18704, 2012 | 154 | 2012 |
P450-Catalyzed Intramolecular sp3 C–H Amination with Arylsulfonyl Azide Substrates R Singh, M Bordeaux, R Fasan ACS catalysis 4 (2), 546-552, 2014 | 146 | 2014 |
Intermolecular carbene S–H insertion catalysed by engineered myoglobin-based catalysts V Tyagi, RB Bonn, R Fasan Chemical science 6 (4), 2488-2494, 2015 | 142 | 2015 |
Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates G Sreenilayam, R Fasan Chemical Communications 51 (8), 1532-1534, 2015 | 129 | 2015 |
Chemo-enzymatic fluorination of unactivated organic compounds A Rentmeister, FH Arnold, R Fasan Nature chemical biology 5 (1), 26-28, 2009 | 123 | 2009 |
Gram‐scale synthesis of chiral cyclopropane‐containing drugs and drug precursors with engineered myoglobin catalysts featuring complementary stereoselectivity P Bajaj, G Sreenilayam, V Tyagi, R Fasan Angewandte Chemie 128 (52), 16344-16348, 2016 | 122 | 2016 |
Highly diastereo-and enantioselective synthesis of trifluoromethyl-substituted cyclopropanes via myoglobin-catalyzed transfer of trifluoromethylcarbene A Tinoco, V Steck, V Tyagi, R Fasan Journal of the American Chemical Society 139 (15), 5293-5296, 2017 | 118 | 2017 |
Enzymatic C(sp3)-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones R Singh, JN Kolev, PA Sutera, R Fasan ACS catalysis 5 (3), 1685-1691, 2015 | 118 | 2015 |
Myoglobin‐Catalyzed Olefination of Aldehydes V Tyagi, R Fasan Angewandte Chemie 128 (7), 2558-2562, 2016 | 97 | 2016 |
P450 fingerprinting method for rapid discovery of terpene hydroxylating P450 catalysts with diversified regioselectivity K Zhang, S El Damaty, R Fasan Journal of the American Chemical Society 133 (10), 3242-3245, 2011 | 96 | 2011 |
Intramolecular C (sp3) H amination of arylsulfonyl azides with engineered and artificial myoglobin-based catalysts M Bordeaux, R Singh, R Fasan Bioorganic & medicinal chemistry 22 (20), 5697-5704, 2014 | 94 | 2014 |
Discovery of Potent Parthenolide-Based Antileukemic Agents Enabled by Late-Stage P450-Mediated C H Functionalization JN Kolev, KM O’Dwyer, CT Jordan, R Fasan ACS chemical biology 9 (1), 164-173, 2014 | 87 | 2014 |