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Cocaine: The First Local Anesthetic and the'Third Scourge of Humanity': A Centennial Melodrama

MF Goldberg - Archives of ophthalmology, 1984 - jamanetwork.com
" For me," said Sherlock Holmes," there still remains the cocaine bottle." Arthur Conan Doyle,
The Sign of Four" The Strange Story of Jonathan Small" PROLOGUE Exactly 100 years ago,
Carl Koller, a 26-year-old Viennese ophthalmologist, first demonstrated the ability of a drug
to induce local anesthesia. Immediately, Koller was thrust into the international limelight,
along with his then obscure colleague and friend, Sigmund Freud, aged 28 years, and with
the internationally respected founding Editor of theArchives of Ophthalmology, Herman …