An unprecedented microgravity observation of maximal shape oscillations of a surfactant-bearing water drop the size of a ping-pong ball was observed during a mission of Space Shuttle Columbia. The goal of the research, of which this observation is a part, was to study the rheological properties of liquid drop surfaces on which are adsorbed surfactant molecules under conditions not possible at 1g. Numerical computation of the evolution of the shape of greatly deformed drops using the boundary integral method has successfully predicted the observed drop shapes over a complete cycle of oscillation, thereby permitting the calculation of the dynamic surface tension under these unique conditions.