Tlatelolco may refer to:

• Tlatelolco (altepetl), a pre-Columbian Aztec citystate
• Tlatelolco (archaeological site), an archaeological site in Mexico City, location of the Aztec citystate
• Tlatelolco, Mexico City, an area in the Cuauhtémoc borough of Mexico City
• Conjunto Urbano Nonoalco Tlatelolco, mega apartment complex
• The Tlatelolco massacre of 1968 in which Mexican police and military forces killed more than 300 protesting students
• Tlatelolco metro station, a station on the Mexico City Metro
• Tlatelolco (Mexico City Metrobús), a BRT station in Mexico City
• Treaty of Tlatelolco, a treaty for the prohibition of nuclear weapons in Latin America and the Caribbean
• Codex of Tlatelolco, a pictorial central Mexican manuscript
• Topos de Tlatelolco, a rescue brigade