IRS is the United States Internal Revenue Service.
IRS may also refer to:
Arts and entertainment[edit]
- I.R.S. Records
- "I.R.S.", a song by Guns N' Roses on their album Chinese Democracy
- Irwin R. Schyster, wrestler Mike Rotunda
- IR$, Franco-Belgian comics
Economics[edit]
Organisations[edit]
- Independence Republic of Sardinia, a political party, Italy
- Leibniz Institute for Research on Society and Space, of the Leibniz Association
Medicine[edit]
- Indoor residual spraying of insecticide
- Insulin receptor substrate, a ligand
- Intergroup Rhabdomyosarcoma Study Group
Transportation[edit]
- Independent rear suspension, a form of car independent suspension
- International Railway Solution, International Union of Railways leaflets
- International Railway Systems, a Romanian company
- IRS Airlines, Nigeria
Other uses[edit]
- International Rules Series, Australia–Ireland football competition
- Indian Remote Sensing satellite
- Indian Readership Survey
- Integrated reception system, for broadcast signals
- Institutionalized Riot Systems