Spinelli is an Italian surname. Notable people with the surname include:

• Altiero Spinelli (1907–1986), Italian advocate for European federalism and founding father of the European Union
• Anita Spinelli (1908-2010), Swiss artist and painter
• Anthony Spinelli (1927–2000), American director of pornographic films
• Antonio Spinelli (bishop) C.R. (1657–1724), Italian Roman Catholic Bishop of Melfi and Rapolla
• Antonio Spinelli (football manager) (born 1980), Argentine football manager
• Ashley Spinelli, a character in the cartoon Recess (TV series)
• Barbara Spinelli (born 1946), Italian politician
• Brunello Spinelli (1939–2018), Italian water polo player
• Chiara Spinelli (1744–1823), Italian noblewoman and pastellist.
• Claudio Spinelli (born 1998), Argentine footballer
• Damian Spinelli, a fictional character on the American soap opera General Hospital
• Elisabetta Spinelli (born 1968), Italian voice actress
• Filippo Spinelli (1566–1616), Roman Catholic cardinal
• Francesco Spinelli (1853–1913), Italian Roman Catholic priest and founder of the Sisters Adorers of the Blessed Sacrament
• Fernando Spinelli, Argentine footballer
• Gennaro Spinelli, Prince of Cariati (1780–1851), Italian politician and diplomat
• Gérard Spinelli, Mayor of the French town of Beausoleil, adjoining part of the Principality of Monaco
• Gianluca Spinelli (born 1966), Italian professional football goalkeeper coach
• Giovanni Battista Spinelli (c.1597–c. 1647), Italian painter
• Giuseppe Spinelli (1694–1763), cardinal prefect of the Congregation for the Evangelization of Peoples
• Giuseppe Spinelli (politician) (1908–1987), Italian politician
• Jerry Spinelli (born 1941), American author
• Juanita Spinelli (1889–1941), the first woman to be executed by the state of California
• Laurita Spinelli, with Carlotta Truman, the German duo of the Eurovision Song Contest 2019
• Luca Spinelli, Swiss investigative journalist and the founder of the legal open source project Oscon
• Mitchell Spinelli, American pornographic film director and producer
• Nicola Antonio Spinelli C.R. (1583–1634), Italian Roman Catholic Bishop of Alessano
• Niccola Spinelli (1865–1909), Italian opera composer
• Parri Spinelli (c. 1387–1453, Italian painter of the early Renaissance
• Pietro Antonio Spinelli (1597–1645), Roman Catholic Archbishop of Rossano
• Spinello di Luca Spinelli (c. 1350–c. 1410), Italian painter from Arezzo
• Tomás Spinelli (born 1993), Argentine footballer
• Troiano Spinelli (1712–1777), Italian nobleman, economic-philosopher, and historian

• Palazzo Corner Spinelli, on the Grand Canal, Venice, Italy
• Palazzo Spinelli di Laurino, Naples, 15-century palace in central Naples, Italy
• Stadio Marco Spinelli, a municipal stadium in Alife, Italy

• Aguilar–Spinelli test, from the United States Supreme Court case, Spinelli v. United States
• Spinelli Group, a network planned for the so-called United States of Europa

• Spinelly, surname page
• Spina (disambiguation)
• Spinetti, surname page