Sambasiva Rao (సాంబశివరావు) is an Indian given name. Notable people with the name include:

• Rayapati Sambasiva Rao, Indian politician and industrialist.
• Kavuri Samba Siva Rao, an Indian politician, engineer and industrialist.
• A. S. Rao or Ayyagari Sambasiva Rao, was an Indian scientist.
• Avula Sambasiva Rao, was an Indian judge.
• S. Rao Kosaraju or Sambasiva Rao Kosaraju is a professor of computer science at Johns Hopkins University,