Protein-coding gene in the species Homo sapiens
Neuroligin-2 is a protein that in humans is encoded by the NLGN2 gene .[5] [6] [7]
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.[7]
References [ edit ]
^ a b c ENSG00000283859 GRCh38: Ensembl release 89: ENSG00000169992, ENSG00000283859 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051790 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene . 246 (1–2): 303–10. doi :10.1016/S0378-1119(00)00049-4 . PMID 10767552 . ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (2): 143–50. doi :10.1093/dnares/7.2.143 PMID 10819331 . ^ a b "Entrez Gene: NLGN2 neuroligin 2" .
Further reading [ edit ]
Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ..." Curr. Biol . 10 (17): R620–3. doi :10.1016/S0960-9822(00)00663-1 PMID 10996085 . S2CID 15851386 . Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins" . J. Biol. Chem . 271 (5): 2676–82. doi :10.1074/jbc.271.5.2676 PMID 8576240 . Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95". Science . 277 (5331): 1511–5. doi :10.1126/science.277.5331.1511 . PMID 9278515 . Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci . 11 (3): 161–72. doi :10.1006/mcne.1998.0679 . PMID 9647694 . S2CID 36534759 . Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (1): 65–73. doi :10.1093/dnares/7.1.65 PMID 10718198 . Scheiffele P, Fan J, Choih J, et al. (2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons" . Cell . 101 (6): 657–69. doi :10.1016/S0092-8674(00)80877-6 PMID 10892652 . S2CID 16095623 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Jamain S, Quach H, Betancur C, et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism" . Nat. Genet . 34 (1): 27–9. doi :10.1038/ng1136 . PMC 1925054 PMID 12669065 .
