Mayo is a given name. Notable people with the name include:
- Mayo Doko (土光 真代, born 1996), Japanese women's footballer
- Mayo Kawasaki (born 1963), Japanese actor
- Mayo Hibi (born 1996), Japanese tennis player
- Mayo Itoyama (糸山 真与, born 1991), Japanese synchronized swimmer
- Mayo Methot (1904-1951), American actress, third wife of Humphrey Bogart
- Mayo Okamoto (born 1974), Japanese singer-songwriter
- Mayo Smith (1915–1977), American baseball player and manager
- Mayo Suzukaze (born 1960), Japanese actress
- Mayo Thompson (born 1944), American musician and visual artist
- Mayo Yamaura (born 1984), Japanese curler