Grech (/ˈɡrɛk/) is a surname of Maltese origin. Notable people with the surname include:
- Amanda Spiteri Grech, Maltese politician
- Joe Grech (born 1934), Maltese singer
- Joe Debono Grech (born 1939), Maltese politician
- Joseph Grech (1948–2010), Maltese bishop of Sandhurst
- Karin Grech (1962–1977), Maltese murder victim
- Leandro Grech (born 1980), Maltese football player
- Lino Grech (1930−2013), Maltese actor, writer and director
- Louis Grech (born 1947), Maltese politician
- Mario Grech (born 1947), Maltese bishop, cardinal and Vatican official
- Martin Grech (born 1982), English musician
- Prosper Grech (1925–2019), Maltese Roman Catholic bishop and cardinal
- Ric Grech (1946–1990), English bassist