Department of Interior may refer to:

• Department of the Interior (1932–39), an Australian government department that existed 1932–1939
• Department of the Interior (1939–72), an Australian government department that existed 1939–1972
• United States Department of the Interior
• Ministry of Interior, a government department typically responsible for policing, emergency management, national security, elections, and immigration
  • List of interior ministries in different countries and their heads