David Sims is the name of:

• David Sims (running back) (born 1955), former American football running back with the Seattle Seahawks
• David Sims (safety) (born 1986), American football safety for the Indianapolis Colts
• Dave Sims (born 1953), Seattle-based sportscaster
• Dave Sims (rugby union) (1969–2022), rugby player
• Dave Sims (swimmer), member of the USA's 1980 Olympic team
• David Sims (biologist) (born 1969), professor in marine biology
• David Sims (photographer) (born 1966), British fashion and beauty photographer
• David Wm. Sims (born 1963), American musician
• David Sims (director) (born 1948), New Zealand film director
• David Sims (critic), The Atlantic film critic and co-host of Blank Check with Griffin & David

• Dave Sim (born 1956), Canadian comic book writer
• Dave Sime (1936–2016), athlete
• David J. Simms (1933–2018), Indian-born Irish mathematician