THC Science

Gender dysphoria
Gender dysphoria
Other names	Gender identity disorder
Specialty	Psychiatry, psychology
Symptoms	Distress related to one's assigned gender, sex, and/or sex characteristics
Complications	Eating disorders, suicide, depression, anxiety, social isolation
Differential diagnosis	Variance in gender identity or expression that is not distressing
Treatment	Transitioning, psychotherapy
Medication	Hormones (e.g., androgens, antiandrogens, estrogens)

Gender dysphoria (GD) is the distress a person feels due to a mismatch between their gender identity—their personal sense of their own gender—and their sex assigned at birth.^[5]^[6] The diagnostic label gender identity disorder (GID) was used until 2013 with the release of the diagnostic manual DSM-5. The condition was renamed to remove the stigma associated with the term disorder.^[7]

People with gender dysphoria commonly identify as transgender.^[8] Gender nonconformity is not the same thing as gender dysphoria^[9] and does not always lead to dysphoria or distress.^[10] According to the American Psychiatric Association, not all transgender people experience dysphoria;^[9] the critical element of gender dysphoria is "clinically significant distress".^[1]

The causes of gender dysphoria are unknown but a gender identity likely reflects genetic, biological, environmental, and cultural factors.^[11]^[12]^[13] Treatment for gender dysphoria may include supporting the individual's gender expression or their desire for hormone therapy or surgery.^[2]^[3] Treatment may also include counseling or psychotherapy.^[3]

Some researchers and transgender people support declassification of the condition because they say the diagnosis pathologizes gender variance and reinforces the binary model of gender.^[14] Without the classification of gender dysphoria as a medical disorder, HRT and gender affirming surgery may be viewed as cosmetic treatments by health insurance, as opposed to medically necessary treatment, and may not be covered.^[15]

Signs and symptoms

Distress arising from an incongruence between a person's felt gender and assigned sex/gender (usually at birth) is the cardinal symptom of gender dysphoria.^[16]^[17]

Gender dysphoria in those assigned male at birth (AMAB) tends to follow one of two broad trajectories: early-onset or late-onset. Early-onset gender dysphoria is behaviorally visible in childhood. Sometimes gender dysphoria will stop for a while in this group and they will identify as gay or homosexual for a period of time, followed by recurrence of gender dysphoria. This group is usually sexually attracted to members of their natal sex in adulthood, commonly identifying as heterosexual or straight. Late-onset gender dysphoria does not include visible signs in early childhood, but some report having had wishes to be the opposite sex in childhood that they did not report to others.^[18] Transgender people assigned male at birth who experience late-onset gender dysphoria will usually be attracted to women and may identify as lesbians or bisexual, while those with early-onset will usually be attracted to men.^[18] A similar pattern occurs in those assigned female at birth (AFAB), with those experiencing early-onset GD being most likely to be attracted to women and those with late-onset being most likely to be attracted to men and identify as gay.^[18]^[19]

Symptoms of GD in children include preferences for opposite sex-typical toys, games, or activities; great dislike of their own genitalia; and a strong preference for playmates of the opposite sex.^[20] Some children may also experience social isolation from their peers, anxiety, loneliness, and depression.^[4] In adolescents and adults, symptoms include the desire to be and to be treated as a different gender.^[20] Adults with GD are at increased risk for stress, isolation, anxiety, depression, poor self-esteem, and suicide.^[4] Transgender people are also at heightened risk for eating disorders^[21] and substance abuse.^[22]

Causes

The specific causes of gender dysphoria remain unknown, and treatments targeting the etiology or pathogenesis of gender dysphoria do not exist.^[23] Evidence from studies of twins suggests that genetic factors play a role in the development of gender dysphoria.^[11]^[12] Gender identity is thought to likely reflect a complex interplay of biological, environmental, and cultural factors.^[13]

Diagnosis

The American Psychiatric Association permits a diagnosis of gender dysphoria in adolescents or adults if two or more of the following criteria are experienced for at least six months' duration:^[20]

A strong desire to be of a gender other than one's assigned gender
A strong desire to be treated as a gender other than one's assigned gender
A significant incongruence between one's experienced or expressed gender and one's sexual characteristics
A strong desire for the sexual characteristics of a gender other than one's assigned gender
A strong desire to be rid of one's sexual characteristics due to incongruence with one's experienced or expressed gender
A strong conviction that one has the typical reactions and feelings of a gender other than one's assigned gender

In addition, the condition must be associated with clinically significant distress or impairment.^[20]

The DSM-5 moved this diagnosis out of the sexual disorders category and into a category of its own.^[20] The diagnosis was renamed from gender identity disorder to gender dysphoria, after criticisms that the former term was stigmatizing.^[24] Subtyping by sexual orientation was deleted. The diagnosis for children was separated from that for adults, as "gender dysphoria in children". The creation of a specific diagnosis for children reflects the lesser ability of children to have insight into what they are experiencing, or ability to express it if they have insight.^[25] Other specified gender dysphoria or unspecified gender dysphoria can be diagnosed if a person does not meet the criteria for gender dysphoria but still has clinically significant distress or impairment.^[20] Intersex people are now included in the diagnosis of GD.^[26]

The International Classification of Diseases (ICD-10) lists several disorders related to gender identity:^[27]^[28]

Transsexualism (F64.0): Desire to live and be accepted as a member of the opposite sex, usually accompanied by a desire for surgery and hormonal treatment
Gender identity disorder of childhood (F64.2): Persistent and intense distress about one's assigned gender, manifested prior to puberty
Other gender identity disorders (F64.8)
Gender identity disorder, unspecified (F64.9)
Sexual maturation disorder (F66.0): Uncertainty about one's gender identity or sexual orientation, causing anxiety or distress

The ICD-11, which came into effect on 1 January 2022, significantly revised classification of gender identity-related conditions.^[29] Under "conditions related to sexual health", the ICD-11 lists "gender incongruence", which is coded into three conditions:^[30]

Gender incongruence of adolescence or adulthood (HA60): replaces F64.0
Gender incongruence of childhood (HA61): replaces F64.2
Gender incongruence, unspecified (HA6Z): replaces F64.9

In addition, sexual maturation disorder has been removed, along with dual-role transvestism.^[31] ICD-11 defines gender incongruence as "a marked and persistent incongruence between an individual’s experienced gender and the assigned sex", with no requirement for significant distress or impairment.

Treatment

Treatment for a person diagnosed with GD may include psychological counseling, supporting the individual's gender expression, or hormone therapy or surgery. This may involve physical transition resulting from medical interventions such as hormonal treatment, genital surgery, electrolysis or laser hair removal, chest/breast surgery, or other reconstructive surgeries.^[32] The goal of treatment may simply be to reduce problems resulting from the person's transgender status, for example, counseling the patient in order to reduce guilt associated with cross-dressing.^[33]

Guidelines have been established to aid clinicians. The World Professional Association for Transgender Health (WPATH) Standards of Care are used by some clinicians as treatment guidelines. Others use guidelines outlined in Gianna Israel and Donald Tarver's Transgender Care.^[34] Guidelines for treatment generally follow a "harm reduction" model.^[35]^[36]^[37]

Children

Medical, scientific, and governmental organizations have opposed conversion therapy, defined as treatment viewing gender nonconformity as pathological and something to be changed, instead supporting approaches that affirm children's diverse gender identities.^[38]^[39]^[40] People are more likely to keep having gender dysphoria the more intense their gender dysphoria, cross-gendered behavior, and verbal identification with the desired/experienced gender are (i.e. stating that they are a different gender rather than wish to be a different gender).^[41]

A 2016 review of 10 prospective follow-up studies from childhood to adolescence found an average desistance rate of 85%, with rates varying widely between studies (from 61% to 98%).^[42]^[43] The review notes numerous methodological difficulties that arise when measuring desistance, including the variation in intensity of gender dysphoria among the children in the studies.^[41] These studies have been criticized on the grounds that they count as 'desistance' cases where the child met the criteria for gender identity disorder as defined in the DSM-III or DSM-IV, but would not have met the updated criteria for gender dysphoria in the DSM-5, established in 2013.^[41]^[44]^{[further explanation needed]} Additionally, the evidence offered has been criticized for citing studies which have been labelled conversion therapy for discouraging social transition and trying to prevent a transgender outcome. The diagnostic criteria for gender dysphoria used in the studies only required gender-nonconformity, and did not require a child to state a transgender identity or a desire for medical or social transition.^[45]^[46]^[47] Most childhood desisters go on to identify as cisgender and gay or lesbian.^[41]^[48] A 2021 study on transgender children who socially transitioned found that 7.3% detransition.^[49]

Professionals who treat gender dysphoria in children sometimes prescribe puberty blockers to delay the onset of puberty until a child is believed to be old enough to make an informed decision on whether hormonal or surgical gender reassignment is in their best interest.^[50]^[51]

A review published in Child and Adolescent Mental Health found that puberty blockers are fully reversible, and that they are associated with such positive outcomes as decreased suicidality in adulthood, improved affect and psychological functioning, and improved social life.^[52]

A review commissioned by the UK Department of Health found that there was very low certainty of quality of evidence about puberty blocker outcomes in terms of mental health, quality of life and impact on gender dysphoria.^[53] The Finnish government commissioned a review of the research evidence for treatment of minors and the Finnish Ministry of Health concluded that there are no research-based health care methods for minors with gender dysphoria.^[54] Nevertheless, they recommend the use of puberty blockers for minors on a case-by-case basis, and the American Academy of Pediatrics state that "pubertal suppression in children who identify as TGD [transgender and gender diverse] generally leads to improved psychological functioning in adolescence and young adulthood.".^[55]

In the United States, several states have introduced or are considering legislation that would prohibit the use of puberty blockers in the treatment of transgender children.^[56] The American Medical Association,^[57] the Endocrine Society,^[58] the American Psychological Association,^[59] the American Academy of Child and Adolescent Psychiatry^[60] and the American Academy of Pediatrics^[61] oppose bans on puberty blockers for transgender children. In the UK, in the case of Bell v Tavistock, an appeal court, overturning the original decision, ruled that children under 16 could give consent to receiving puberty blockers.^[62]

Psychological treatments

Until the 1970s, psychotherapy was the primary treatment for gender dysphoria and generally was directed to helping the person adjust to their assigned sex. Psychotherapy is any therapeutic interaction that aims to treat a psychological problem. Psychotherapy may be used in addition to biological interventions, although some clinicians use only psychotherapy to treat gender dysphoria.^[23] Psychotherapeutic treatment of GD involves helping the patient to adapt to their gender incongruence or to explorative investigation of confounding co-occurring^[63]^[64]^[65]^[66] mental health issues. Attempts to alleviate GD by changing the patient's gender identity to reflect assigned sex have been ineffective and are regarded as conversion therapy by most health organizations.^[38]^[67]^: 1741

Biological treatments

Biological treatments physically alter primary and secondary sex characteristics to reduce the discrepancy between an individual's physical body and gender identity.^[68] Biological treatments for GD are typically undertaken in conjunction with psychotherapy; however, the WPATH Standards of Care state that psychotherapy should not be an absolute requirement for biological treatments.^[69] It is known that some mental disorders are important to evaluate and treat before proceeding with hormones or surgery, as treatment of these mental disorders can sometimes make the wish for altering one's body disappear or significantly lessen.^[68]

Psychotherapy, hormone therapy, and sex reassignment surgery can be effective at treating GD when the WPATH Standards of Care 6 are followed.^[67]^: 1570 Hormonal treatments have been shown to reduce a number of symptoms of psychiatric distress associated with gender dysphoria.^[70] A WPATH commissioned systematic review of the outcomes of hormone therapy "found evidence that gender-affirming hormone therapy may be associated with improvements in [quality of life] scores and decreases in depression and anxiety symptoms among transgender people." The strength of the evidence was low due to methodological limitations of the studies undertaken.^[71] Some literature suggests that gender-affirming surgery is associated with improvements in quality of life and decreased incidence of depression.^[72] Those who choose to undergo sex reassignment surgery report high satisfaction rates with the outcome, though these studies have limitations including risk of bias (lack of randomization, lack of controlled studies, self-reported outcomes) and high loss to follow up.^[73]^[74]^[75]

For adolescents, much is unknown, including persistence. Disagreement among practitioners regarding treatment of adolescents is in part due to the lack of long-term data.^[63] Young people qualifying for biomedical treatment according to the Dutch model^[76]^[77] (including having GD from early childhood on which intensifies at puberty and absence of psychiatric comorbidities that could challenge diagnosis or treatment) found reduction in gender dysphoria, although limitations to these outcome studies have been noted, such as lack of controls or considering alternatives like psychotherapy.^[78]

More rigorous studies are needed to assess the effectiveness, safety, and long-term benefits and risks of hormonal and surgical treatments.^[73] For instance, a 2020 Cochrane review found insufficient evidence^[79] to determine whether feminizing hormones were safe or effective. A 2021 review published in the Journal of the Endocrine Society found hormone therapy was associated with increased quality of life, decreased depression, and decreased anxiety. Associations were similar across gender identity and age.^[80] Several studies have found significant long-term psychological and psychiatric pathology after surgical treatments.^[73]

In 2021, a review published in Plastic And Reconstructive Surgery found that less than 1% of people who undergo gender-affirming surgery regret the decision.^[81]

Comorbidities

Among youth, around 20% to 30% of individuals attending gender clinics meet the DSM criteria for an anxiety disorder.^[82] Gender dysphoria is also associated with an increased risk of eating disorders in transgender youth.^[83]

A widely held view among clinicians is that there is an over-representation of neurodevelopmental conditions amongst individuals with GD, although this view has been questioned.^[84] Studies on children and adolescents with gender dysphoria have found a high prevalence of autism spectrum disorder (ASD) traits or a confirmed diagnosis of ASD. Adults with gender dysphoria attending specialist gender clinics have also been shown to have high rates of ASD traits or an autism diagnosis as well.^[85] It has been estimated that children with ASD were over four times as likely to be diagnosed with GD,^[84] with ASD being reported from 6% to over 20% of teens referring to gender identity services.^[86]

Epidemiology

Different studies have arrived at different conclusions about the prevalence of gender dysphoria. The DSM-5 estimates that about 0.005% to 0.014% of people assigned male at birth and 0.002% to 0.003% of people assigned female at birth are diagnosable with gender dysphoria.^[87]

According to Black's Medical Dictionary, gender dysphoria "occurs in one in 30,000 male births and one in 100,000 female births."^[88] Studies in European countries in the early 2000s found that about 1 in 12,000 natal male adults and 1 in 30,000 natal female adults seek out sex reassignment surgery.^[89] Studies of hormonal treatment or legal name change find higher prevalence than sex reassignment, with, for example a 2010 Swedish study finding that 1 in 7,750 adult natal males and 1 in 13,120 adult natal females requested a legal name change to a name of the opposite gender.^[89]

Studies that measure transgender status by self-identification find even higher rates of gender identity different from sex assigned at birth (although some of those who identify as transgender or gender nonconforming may not experience clinically significant distress and so do not have gender dysphoria). A study in New Zealand found that 1 in 3,630 natal males and 1 in 22,714 natal females have changed their legal gender markers.^[89] A survey of Massachusetts adults found that 0.5% identify as transgender.^[89]^[90] A national survey in New Zealand of 8,500 randomly selected secondary school students from 91 randomly selected high schools found 1.2% of students responded "yes" to the question "Do you think you are transgender?".^[91] Outside of a clinical setting, the stability of transgender or non-binary identities is unknown.^[89]

Research indicates people who transition in adulthood are up to three times more likely to be male assigned at birth, but that among people transitioning in childhood the sex ratio is close to 1:1.^[92] The prevalence of gender dysphoria in children is unknown due to the absence of formal prevalence studies.^[41]

History

Neither the DSM-I (1952) nor the DSM-II (1968) contained a diagnosis analogous to gender dysphoria. Gender identity disorder first appeared as a diagnosis in the DSM-III (1980), where it appeared under "psychosexual disorders" but was used only for the childhood diagnosis. Adolescents and adults received a diagnosis of transsexualism (homosexual, heterosexual, or asexual type). The DSM-III-R (1987) added "Gender Identity Disorder of Adolescence and Adulthood, Non-Transsexual Type" (GIDAANT).^[93]^[94]^[95]

Society and culture

Researchers disagree about the nature of distress and impairment in people with GD. Some authors have suggested that people with GD suffer because they are stigmatized and victimized;^[14]^[96] and that, if society had less strict gender divisions, transgender people would suffer less.^[97]

Some controversy surrounds the creation of the GD diagnosis, with Davy et al. stating that although the creators of the diagnosis state that it has rigorous scientific support, "it is impossible to scrutinize such claims, since the discussions, methodological processes, and promised field trials of the diagnosis have not been published."^[26]

Some cultures have three or more defined genders. The existence of accepted social categories other than man or woman may alleviate the distress associated with cross-gender identity. For example, in Samoa, the fa'afafine, a group of feminine males, are mostly socially accepted. The fa'afafine appear similar to transgender women in terms of their lifelong identities and gendered behavior, but experience far less distress than do transgender women in Western cultures. This suggests that the distress of gender dysphoria is mostly not caused by the cross-gender identity itself, but by difficulties encountered from social disapproval by one's culture.^[98] Overall, it is unclear whether or not gender dysphoria persists in cultures with third gender categories.^[99]

Classification as a disorder

The psychiatric diagnosis of gender identity disorder (now gender dysphoria) was introduced in DSM-III in 1980. Arlene Istar Lev and Deborah Rudacille have characterized the addition as a political maneuver to re-stigmatize homosexuality.^[100]^[101] (Homosexuality was declassified as a mental disorder in the DSM-II in 1974.) By contrast, Kenneth Zucker and Robert Spitzer argue that gender identity disorder was included in DSM-III because it "met the generally accepted criteria used by the framers of DSM-III for inclusion."^[102] Some researchers, including Spitzer and Paul J. Fink, contend that the behaviors and experiences seen in transsexualism are abnormal and constitute a dysfunction.^[103] The American Psychiatric Association stated that gender nonconformity is not the same thing as gender dysphoria,^[9] and that "gender nonconformity is not in itself a mental disorder. The critical element of gender dysphoria is the presence of clinically significant distress associated with the condition."^[1]

Individuals with gender dysphoria may or may not regard their own cross-gender feelings and behaviors as a disorder. Advantages and disadvantages exist to classifying gender dysphoria as a disorder.^[3] Because gender dysphoria had been classified as a disorder in medical texts (such as the previous DSM manual, the DSM-IV-TR, under the name "gender identity disorder"), many insurance companies are willing to cover some of the expenses of sex reassignment therapy. Without the classification of gender dysphoria as a medical disorder, sex reassignment therapy may be viewed as a cosmetic treatment, rather than medically necessary treatment, and may not be covered.^[15] In the United States, transgender people are less likely than others to have health insurance, and often face hostility and insensitivity from healthcare providers.^[104] Some researchers and transgender people support declassification of the condition because they say the diagnosis pathologizes gender variance and reinforces the binary model of gender.^[14]

An analysis of the Samoan third gender fa'afafine suggests that the DSM-IV-TR diagnostic component of distress is not inherent in the cross-gender identity; rather, it is related to social rejection and discrimination suffered by the individual.^[98] Psychology professor Darryl Hill insists that gender dysphoria is not a mental disorder, but rather that the diagnostic criteria reflect psychological distress in children that occurs when parents and others have trouble relating to their child's gender variance.^[103] Transgender people have often been harassed, socially excluded, and subjected to discrimination, abuse and violence, including murder.^[4]^[97]

In December 2002, the British Lord Chancellor's office published a Government Policy Concerning Transsexual People document that categorically states, "What transsexualism is not ... It is not a mental illness."^[105] In May 2009, the government of France declared that a transsexual gender identity will no longer be classified as a psychiatric condition,^[106] but according to French trans rights organizations, beyond the impact of the announcement itself, nothing changed.^[107] Denmark made a similar statement in 2016.^[108]

In the ICD-11, GID is reclassified as "gender incongruence", a condition related to sexual health.^[30] The working group responsible for this recategorization recommended keeping such a diagnosis in ICD-11 to preserve access to health services.^[31]

Gender euphoria

Gender euphoria (GE) is a proposed term for the opposite of gender dysphoria. It is the satisfaction, enjoyment, or relief felt by trans people when they feel their body matches their personal gender identity.^[89]^[109] Healthline defines it as "feelings of alignment or joy about [one's] gender identity or expression,"^[110] while Psych Central's definition is "deep joy when your internal gender identity matches your gender expression."^[111]

In 1979, the term "gender euphoria" was first published; however, it was then used to describe male privilege present in Black cisgender men.^[112]^[113]

In 1986, the term was first published in a trans context, as part of an interview with a trans person: "gender dysphoria, and a term of which he seems inordinately proud, gender euphoria."^[114] Similar uses were published in 1988.^[115]^[116]

In a 1988 interview with a trans man, the subject states, "I think that day [Dr. Charles Ilhenfeld] administered my first shot of the 'wonder-drug' must have been one of the 'peak-experiences' of my life -- talk about 'gender euphoria'!"^[117] The interview indicates he is referring to testosterone.^[117]

In 1989, Mariette Pathy Allen published an unnamed transgender person's quote in her photography book Transformations: "The shrinks may call it 'gender dysphoria,' but for some of us, it's gender 'euphoria,' and we're not going to apologize anymore!"^[118]

In 1990, Virginia Prince used the phrase in trans magazine Femme Mirror, ending an article with, "...from here on you can enjoy GENDER EUPHORIA - HAVE A GOOD LIFE!"^[119]

Starting in 1991, a monthly newsletter named Gender Euphoria was released,^[120] featuring articles about transgender topics; Leslie Feinberg read the newsletter to better understand the transgender community.^[121] In 1993, the blurb of Nan Goldin's The Other Side read, "The pictures in this book are not of people suffering dysphoria but rather expressing gender euphoria."^[122]

In 1994, Scottish "TV/TS" periodical The Tartan Skirt wrote, "Let's accentuate the positive, discard the negative, and promote the new condition of 'Gender Euphoria.'"^[123]

In 1997, Patrick Califia described transgender activists picketing using signs that read "Gender Euphoria NOT Gender Dysphoria" and handing out "thousands of leaflets" at protests.^[124]

The following year, in 1998, Second Skins: The Body Narratives of Transsexuality reported:

The transactivist group Transexual Menace is campaigning to have the diagnosis "Gender Identity Disorder" removed entirely from the Diagnostic and Statistical Manual of Mental Disorders. "Gender Euphoria NOT Gender Dysphoria"; its slogans invert the pathologizing of transgender, offering pride in queer difference as an alternative to the psychiatric story.^[125]

Transgender congruence is also used to ascribe transgender individuals feeling genuine, authentic, and comfortable with their gender identity and external appearance.^[126]^[127]

In 2019, the Midsumma festival in Australia hosted "Gender Euphoria," a cabaret focusing on "bliss" in transgender experiences, including musical, ballet, and burlesque performances.^[128]^[129]^[130]^[131] A reviewer described it as "triumphant – honest, unpretentious, touching, and a vital celebration."^[129]

References

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^ ^a ^b Reed GM, Drescher J, Krueger RB, Atalla E, Cochran SD, First MB, Cohen-Kettenis PT, Arango-de Montis I, Parish SJ, Cottler S, Briken P, Saxena S (October 2016). "Disorders related to sexuality and gender identity in the ICD-11: revising the ICD-10 classification based on current scientific evidence, best clinical practices, and human rights considerations". World Psychiatry. 15 (3): 205–221. doi:10.1002/wps.20354. PMC 5032510. PMID 27717275.
^ "NHS - Treatment - Gender dysphoria". NHS. 2016. Retrieved January 10, 2019.
^ Leiblum, Sandra (2006). Principles and Practice of Sex Therapy, Fourth Edition. The Guilford Press. pp. 488–9. ISBN 978-1-59385-349-5.
^ Heyes, C. J., & Latham, J. R. (2018). Trans surgeries and cosmetic surgeries: The politics of analogy. Transgender Studies Quarterly, 5(2), 174-189.
^ Committee On Adolescence (July 2013). "Office-based care for lesbian, gay, bisexual, transgender, and questioning youth". Pediatrics. 132 (1): 198–203. doi:10.1542/peds.2013-1282. PMID 23796746. However, adolescents with multiple or anonymous partners, having unprotected intercourse, or having substance abuse issues should be tested at shorter intervals.
^ "www.glma.org Compendium of Health Profession Association LGBT Policy & Position Statements" (PDF). GLMA. 2013. Retrieved August 27, 2013.
^ "APA Policy Statements on Lesbian, Gay, Bisexual, & Transgender Concerns" (PDF). American Psychological Association. 2011. Retrieved August 27, 2013. Be it further resolved that APA recognizes the efficacy, benefit, and necessity of gender transition treatments for appropriately evaluated individuals and calls upon public and private insurers to cover these medically necessary treatments
^ ^a ^b "Health and Medical Organization Statements on Sexual Orientation, Gender Identity/Expression and 'Reparative Therapy'". lambdalegal.org. Lambda Legal.
^ "Policy and Position Statements on Conversion Therapy". Human Rights Campaign. Human Rights Campaign. Retrieved 12 April 2017.
^ American Psychiatric Association (December 2018). "Position Statement on Therapies Focused on Attempts to Change Sexual Orientation (Reparative or Conversion Therapies)" (PDF). American Psychiatric Association. Archived from the original (PDF) on 10 December 2021. While many might identify as questioning, queer, or a variety of other identities, 'reparative' or conversion therapy is based on the a priori assumption that diverse sexual orientations and gender identities are mentally ill and should change ... APA encourages legislation which would prohibit the practice of 'reparative' or conversion therapies that are based on the a priori assumption that diverse sexual orientations and gender identities are mentally ill(references omitted)
^ ^a ^b ^c ^d ^e Ristori, Jiska; Steensma, Thomas D. (2 January 2016). "Gender dysphoria in childhood". International Review of Psychiatry. 28 (1): 13–20. doi:10.3109/09540261.2015.1115754. PMID 26754056. S2CID 5461482.
^ Kaltiala-Heino, Riittakerttu; Bergman, Hannah; Työläjärvi, Marja; Frisén, Louise (2018-03-02). "Gender dysphoria in adolescence: current perspectives". Adolescent Health, Medicine and Therapeutics. 9: 31–41. doi:10.2147/AHMT.S135432. ISSN 1179-318X. PMC 5841333. PMID 29535563. Evidence from the 10 available prospective follow-up studies from childhood to adolescence (reviewed in the study by Ristori and Steensma 28) indicates that for ~80% of children who meet the criteria for GDC, the GD recedes with puberty. Instead, many of these adolescents will identify as non-heterosexual.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Ristori, Jiska; Steensma, Thomas D. (2016). "Gender dysphoria in childhood". International Review of Psychiatry (Abingdon, England). 28 (1): 13–20. doi:10.3109/09540261.2015.1115754. ISSN 1369-1627. PMID 26754056. S2CID 5461482. As is shown in Table 1 there is much variation in the reported persistence rates between the studies, ranging from 2% to 39%. ... Based on this information, it seems reasonable to conclude that the persistence of GD may well be higher than 15%. However, desistence of GD still seems to be the case in the majority of children with GD.
^ Temple Newhook, Julia; Pyne, Jake; Winters, Kelley; Feder, Stephen; Holmes, Cindy; Tosh, Jemma; Sinnott, Mari-Lynne; Jamieson, Ally; Pickett, Sarah (2018-04-03). "A critical commentary on follow-up studies and "desistance" theories about transgender and gender-nonconforming children". International Journal of Transgenderism. 19 (2): 212–224. doi:10.1080/15532739.2018.1456390. ISSN 1553-2739. S2CID 150338824.
^ Ashley, Florence (2021-09-02). "The clinical irrelevance of "desistance" research for transgender and gender creative youth". Psychology of Sexual Orientation and Gender Diversity. doi:10.1037/sgd0000504. ISSN 2329-0390. S2CID 239099559. Archived from the original on 3 March 2022. Retrieved 3 March 2022.
^ Newhook, Julia Temple; Pyne, Jake; Winters, Kelley; Feder, Stephen; Holmes, Cindy; Tosh, Jemma; Sinnott, Mari-Lynne; Jamieson, Ally; Pickett, Sarah (2018-04-03). "A critical commentary on follow-up studies and "desistance" theories about transgender and gender-nonconforming children". International Journal of Transgenderism. 19 (2): 212–224. doi:10.1080/15532739.2018.1456390. ISSN 1553-2739. S2CID 150338824.
^ Steensma, Thomas (2018). "A critical commentary on "A critical commentary on follow-up studies and "desistence" theories about transgender and gender non-conforming children"". International Journal of Transgenderism. 19 (2): 225–230. doi:10.1080/15532739.2018.1468292. S2CID 150062632 – via Taylor & Francis Online.
^ Butler, Catherine; Hutchinson, Anna (2020). "Debate: The pressing need for research and services for gender desisters/Detransitioners". Child and Adolescent Mental Health. 25 (1): 45–47. doi:10.1111/camh.12361. PMID 32285632. S2CID 210484832.
^ Holcombe, Madeline (2022-05-10). "Kids usually stay consistent when they socially transition young, according to a study". CNN. Retrieved 2022-06-07.
^ The Transgendered Child: A Handbook for Families and Professionals (Brill and Pepper, 2008)^{[full citation needed]}^{[page needed]}
^ Alleyne, Richard (15 April 2011). "Puberty blocker for children considering sex change". The Telegraph. Archived from the original on 2022-01-11. Retrieved 1 December 2020.
^ Rew, Lynn; Young, Cara; Monge, Maria; Bogucka, Roxanne. "Review: Puberty blockers for transgender and gender diverse youth-a critical review of the literature". Child and Adolescent Mental Health. PMID 33320999. Positive outcomes were decreased suicidality in adulthood, improved affect and psychological functioning, and improved social life.
^ "Evidence review: Gonadotrophin releasing hormone analogues for children and adolescents with gender dysphoria". Retrieved 2 April 2021. The critical outcomes for decision making are the impact on gender dysphoria, mental health and quality of life. The quality of evidence for these outcomes was assessed as very low certainty using modified GRADE.{{cite web}}: CS1 maint: url-status (link)
^ "Finnish guidelines for treatment of child and adolescent gender dysphoria (published march 2021)" (PDF). Council for Choices in Health Care (COHERE). Retrieved 22 April 2021. p. 6: Terveydenhuoltolain mukaan (8§) terveydenhuollon toiminnan on perustuttava näyttöön ja hyviin hoito- ja toimintakäytäntöihin. Alaikäisten osalta tutkimusnäyttöön perustuvia terveydenhuollon menetelmiä ei ole. [According to the Health Care Act (Section 8), health care activities must be based on evidence and good care and operating practices. There are no research-based health care methods for minors. [translation provided by Wikipedia]]{{cite web}}: CS1 maint: url-status (link)
^ Rafferty, Jason; Health, Committee on Psychosocial Aspects of Child and Family; Adolescence, Committee On; Section on Lesbian, Gay (2018-10-01). "Ensuring Comprehensive Care and Support for Transgender and Gender-Diverse Children and Adolescents". Pediatrics. 142 (4): e20182162. doi:10.1542/peds.2018-2162. ISSN 0031-4005. PMID 30224363.
^ Safer, Joshua D. (17 February 2020). "Controversial pubertal blocker legislation may bring unintended consequences for children". Healio. Retrieved 15 December 2020.
^ "AMA fights to protect health care for transgender patients". State Advocacy Update. American Medical Association. March 26, 2021.
^ "Endocrine Society urges policymakers to follow science on transgender health: Texas custody case prompts unfounded claims". Endocrine Society (Press release). Washington, DC. October 28, 2019.
^ "Criminalizing Gender Affirmative Care with Minors: Suggested Discussion Points With Resources to Oppose Transgender Exclusion Bills". American Psychological Association.
^ "AACAP Statement Responding to Efforts to ban Evidence-Based Care for Transgender and Gender Diverse Youth". American Academy of Child and Adolescent Psychiatry. 8 November 2019.
^ Schmidt, Samantha (22 April 2021). "FAQ: What you need to know about transgender children". The Washington Post.
^ Siddique, Haroon (17 September 2021). "Appeal court overturns UK puberty blockers ruling for under-16s 17 September 2021". Guardian. Guardian. Retrieved 17 September 2021.
^ ^a ^b Kaltiala-Heino, Riittakerttu; Sumia, Maria; Työläjärvi, Marja; Lindberg, Nina (2015). "Two years of gender identity service for minors: overrepresentation of natal girls with severe problems in adolescent development". Child and Adolescent Psychiatry and Mental Health. 9: 9. doi:10.1186/s13034-015-0042-y. ISSN 1753-2000. PMC 4396787. PMID 25873995. for the majority of adolescent-onset cases, GD presented in the context of severe mental disorders and general identity confusion. In such situations, appropriate treatment for psychiatric comorbidities may be warranted before conclusions regarding gender identity can be drawn."; "There is still no clear consensus regarding hormonal treatment for adolescents because long-term data are unavailable"; "In a nationwide long-term follow-up study of adult cases, psychiatric morbidity, suicide attempts and suicide mortality persisted as elevated after juridical and medical SR.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Development of the diagnosis gender dysphoria" (PDF). Swedish National Board of Health and Welfare (in Swedish). Feb 2020. Retrieved 13 March 2021.{{cite web}}: CS1 maint: url-status (link)
^ Kozlowska, Kasia; Chudleigh, Catherine; McClure, Georgia; Maguire, Ann M.; Ambler, Geoffrey R. (2021-01-12). "Attachment Patterns in Children and Adolescents With Gender Dysphoria". Frontiers in Psychology. 11: 582688. doi:10.3389/fpsyg.2020.582688. ISSN 1664-1078. PMC 7835132. PMID 33510668.
^ D’Angelo, Roberto; Syrulnik, Ema; Ayad, Sasha; Marchiano, Lisa; Kenny, Dianna Theadora; Clarke, Patrick (2021-01-01). "One Size Does Not Fit All: In Support of Psychotherapy for Gender Dysphoria". Archives of Sexual Behavior. 50 (1): 7–16. doi:10.1007/s10508-020-01844-2. ISSN 1573-2800. PMC 7878242. PMID 33089441.
^ ^a ^b George R. Brown, MD (July 20, 2011). "Chapter 165 Sexuality and Sexual Disorders". In Robert S. Porter, MD; et al. (eds.). The Merck Manual of Diagnosis and Therapy (19th ed.). Whitehouse Station, NJ, USA: Merck & Co., Inc. pp. 1740–1747. ISBN 978-0-911910-19-3.
^ ^a ^b Bockting, W; Knudson, G; Goldberg, J (January 2006). "Counselling and Mental Health Care of Transgender Adults and Loved Ones". International Journal of Transgenderism. 9 (3–4): 35–82. doi:10.1300/J485v09n03_03. S2CID 71503744. As per Figure 1, delusions about sex or gender, dissociative disorders, thought disorders,or obsessive or compulsive features should be evaluated and treated prior to proceeding with hormone therapy or surgery. Thought disorders, dissociative disorders, and obsessive-compulsive disorders can, rarely, cause a transient wish for sex reassignment which disappears or significantly lessens when the underlying mental health condition is treated. It is important to treat these disorders before proceeding with hormones or surgery to ensure that the desire for alteration of primary or secondary sex characteristics is not a temporary desire. See also WPATH Standards of Care, version 7, page 23: "The role of mental health professionals includes making reasonably sure that the gender dysphoria is not secondary to or better accounted for by other diagnoses." And the paradigmatic Dutch model for consideration of comorbid conditions before proceeding with treatment for childhood onset.
^ "Standards of Care for the Health of Transsexual, Transgender, and Gender Nonconforming People" (PDF). World Professional Association for Transgender Health. pp. 28–29. Retrieved 15 March 2021.
^ Altinay, Murat; Anand, Amit (2020). "Neuroimaging gender dysphoria: a novel psychobiological model". Brain Imaging and Behavior. 14 (4): 1281–1297. doi:10.1007/s11682-019-00121-8. PMID 31134582. S2CID 167207854. Retrieved 2021-10-16. A recently published study (Colizzi et al. 2014), where 118 patients were followed before and 12 months after HRT revealed that 14% of the patients had comorbid Axis-I psychiatric diagnosis. Psychiatric distress and impairment were found to be higher in the beginning phase of the study but after HRT, there was a significant improvement in major depressive disorder, anxiety and functional impairment. Similarly, Fisher and colleagues' (Fisher et al. 2013) 2013 paper suggests that the dysfunction and impairment in the transgender population is highly associated with lack of HRT, which may suggest that at least a fraction of the impairment that was documented as comorbid Axis-I psychiatric disorders could in fact be impairment from GD. Finally, a metanalysis done by Dhejne and colleagues (Dhejne et al. 2016) reviewed 38 longitudinal studies that investigated psychiatric comorbidities pre and post gender affirmation treatments in transgender people with GD. The results of this analysis indicate that depression and GAD do have higher prevalence in transgender population but this finding was isolated to baseline (pre-gender affirmation treatments) where after gender affirmation therapies, rate of psychiatric comorbidities decreased to cisgender population levels
^ Baker, Kellan E.; Wilson, Lisa M.; Sharma, Ritu; Dukhanin, Vadim; McArthur, Kristen; Robinson, Karen A. (2021). "Hormone Therapy, Mental Health, and Quality of Life Among Transgender People: A Systematic Review". Journal of the Endocrine Society. 5 (4): bvab011. doi:10.1210/jendso/bvab011. PMC 7894249. PMID 33644622. This systematic review of 20 studies found evidence that gender-affirming hormone therapy may be associated with improvements in QOL scores and decreases in depression and anxiety symptoms among transgender people. Associations were similar across gender identity and age. The strength of evidence for these conclusions is low due to methodological limitations.
^ Wernick, Jeremy A.; Busa, Samantha; Matouk, Kareen; Nicholson, Joey; Janssen, Aron (2019-11-01). "A Systematic Review of the Psychological Benefits of Gender-Affirming Surgery". Urologic Clinics of North America. Gender Affirming Surgery. 46 (4): 475–486. doi:10.1016/j.ucl.2019.07.002. ISSN 0094-0143. PMID 31582022. S2CID 201997501.
^ ^a ^b ^c Hembree, Wylie C; Cohen-Kettenis, Peggy T; Gooren, Louis; Hannema, Sabine E; Meyer, Walter J; Murad, M Hassan; Rosenthal, Stephen M; Safer, Joshua D; Tangpricha, Vin; T’Sjoen, Guy G (2017-11-01). "Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline". The Journal of Clinical Endocrinology & Metabolism. 102 (11): 3869–3903. doi:10.1210/jc.2017-01658. ISSN 0021-972X. PMID 28945902. In the future, we need more rigorous evaluations of the effectiveness and safety of endocrine and surgical protocols.Specifically, endocrine treatment protocols for GD/gender incongruence should include the careful assessment of the following: (1) the effects of prolonged delay of puberty in adolescents on bone health, gonadal function, and the brain (including effects on cognitive, emotional, social, and sexual development); [...] and (4) the risks and benefits of gender-affirming hormone treatment in older transgender people." "Future research is needed to ascertain the potential harm of hormonal therapies (176)." "The satisfaction rate with surgical reassignment of sex is now very high (187)." "Owing to the lack of controlled studies, incomplete follow-up, and lack of valid assessment measures, evaluating various surgical approaches and techniques is difficult." "Several postoperative studies report significant long-term psychological and psychiatric pathology (259–261)." "We need more studies with appropriate controls that examine long-term quality of life, psychosocial outcomes, and psychiatric outcomes to determine the long-term benefits of surgical treatment.
^ Murad, Mohammad Hassan; Elamin, Mohamed B.; Garcia, Magaly Zumaeta; Mullan, Rebecca J.; Murad, Ayman; Erwin, Patricia J.; Montori, Victor M. (February 2010). "Hormonal therapy and sex reassignment: a systematic review and meta-analysis of quality of life and psychosocial outcomes". Clinical Endocrinology. 72 (2): 214–231. doi:10.1111/j.1365-2265.2009.03625.x. ISSN 1365-2265. PMID 19473181. S2CID 19590739. The evidence in this review is of very low quality9, 10 due to the serious methodological limitations of included studies. Studies lacked bias protection measures such as randomization and control groups, and generally depended on self-report to ascertain the exposure (i.e. hormonal therapy was self-reported as opposed to being extracted from medical records). Our reliance on reported outcome measures may also indicate a higher risk of reporting bias within the studies. Statistical heterogeneity of the results was also significant.
^ Sutcliffe, P. A.; Dixon, S.; Akehurst, R. L.; Wilkinson, A.; Shippam, A.; White, S.; Richards, R.; Caddy, C. M. (March 2009). "Evaluation of surgical procedures for sex reassignment: a systematic review". Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 62 (3): 294–306, discussion 306–308. doi:10.1016/j.bjps.2007.12.009. ISSN 1878-0539. PMID 18222742. The evidence concerning gender reassignment surgery in both MTF and FTM transsexism has several limitations in terms of: (a) lack of controlled studies, (b) evidence has not collected data prospectively, (c) high loss to follow up and (d) lack of validated assessment measures. Some satisfactory outcomes were reported, but the magnitude of benefit and harm for individual surgical procedures cannot be estimated accurately using the current available evidence.
^ Cohen-Kettenis, Peggy T.; Delemarre-van de Waal, Henriette A.; Gooren, Louis J. G. (2008). "The treatment of adolescent transsexuals: changing insights". The Journal of Sexual Medicine. 5 (8): 1892–1897. doi:10.1111/j.1743-6109.2008.00870.x. ISSN 1743-6109. PMID 18564158.
^ de Vries, Annelou L. C.; McGuire, Jenifer K.; Steensma, Thomas D.; Wagenaar, Eva C. F.; Doreleijers, Theo A. H.; Cohen-Kettenis, Peggy T. (2014). "Young adult psychological outcome after puberty suppression and gender reassignment". Pediatrics. 134 (4): 696–704. doi:10.1542/peds.2013-2958. ISSN 1098-4275. PMID 25201798. S2CID 18155489.
^ Zucker, Kenneth J. (2019-10-01). "Adolescents with Gender Dysphoria: Reflections on Some Contemporary Clinical and Research Issues". Archives of Sexual Behavior. 48 (7): 1983–1992. doi:10.1007/s10508-019-01518-8. ISSN 1573-2800. PMID 31321594. S2CID 197663705. In the Dutch model, several factors were identified in deeming adolescent eligibility for early biomedical treatment. According to Cohen-Kettenis, Delemarre-van de Waal, and Gooren (2008), these included the following: (1) the presence of gender dysphoria from early childhood on; (2) an exacerbation of the gender dysphoria after the first signs of puberty; (3) the absence of psychiatric comorbidity that would interfere with a diagnostic evaluation or treatment; (4) adequate psychological and social support during treatment; and (5) a demonstration of knowledge of the sex/gender reassignment process. Several studies have reported on the benefits of this therapeutic protocol in reducing gender dysphoria (e.g., de Vries et al., 2014, which is the best study to date). Of course, one should bear in mind some of the limitation to these outcome studies, including the fact that not all assessed adolescents were deemed eligible for the treatment protocol (and thus we know relatively little about the longer-term outcomes of these youth) and that study designs have not included alternative treatment options (such as psychosocial therapy) or even being assigned to a wait-list control condition
^ Haupt, Claudia; Henke, Miriam; Kutschmar, Alexia; Hauser, Birgit; Baldinger, Sandra; Saenz, Sarah Rafaela; Schreiber, Gerhard (2020-11-28). "Antiandrogen or estradiol treatment or both during hormone therapy in transitioning transgender women". Cochrane Database of Systematic Reviews. 2020 (11): CD013138. doi:10.1002/14651858.cd013138.pub2. ISSN 1465-1858. PMC 8078580. PMID 33251587. We found insufficient evidence to determine the efficacy or safety of hormonal treatment approaches for transgender women in transition.
^ Baker, Kellan; Wilson, Lisa; Sharma, Ritu; Dukhanin, Vadim; McArthur, Kristen; Robinson, Karen (2021-02-02). "Hormone Therapy, Mental Health, and Quality of Life Among Transgender People: A Systematic Review". Journal of the Endocrine Society. 5 (4). Hormone therapy was associated with increased QOL, decreased depression, and decreased anxiety.
^ Bustos, Valeria; Bustos, Samyd; Mascaro, Andres; Del Corral, Gabriel; Forte, Antonio; Ciudad, Pedro; Kim, Esther; Langstein, Howard; Manrique, Oscar (March 2021). "Regret after Gender-affirmation Surgery: A Systematic Review and Meta-analysis of Prevalence". Plastic and Reconstructive Surgery. 9 (3): e3477. doi:10.1097/GOX.0000000000003477. PMC 8099405. PMID 33968550. Archived from the original on 2022-04-06. Retrieved 2022-04-15.
^ Janssen, Aron; Leibowitz, Scott (2018-05-22). Affirmative Mental Health Care for Transgender and Gender Diverse Youth: A Clinical Guide. Springer. p. 8. ISBN 978-3-319-78307-9.
^ Coelho, Jennifer S; Suen, Janet; Clark, Beth A; et al. (October 15, 2019). "Eating Disorder Diagnoses and Symptom Presentation in Transgender Youth: A Scoping Review". Current Psychiatry Reports. 21 (11): 107. doi:10.1007/s11920-019-1097-x. PMID 31617014. S2CID 204542613 – via EBSCOhost. Significantly higher rates of eating disorder symptoms were documented in transgender youth compared to cisgender youth.
^ ^a ^b Thrower, Emily; Bretherton, Ingrid; Pang, Ken C.; Zajac, Jeffrey D.; Cheung, Ada S. (2020-03-01). "Prevalence of Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder Amongst Individuals with Gender Dysphoria: A Systematic Review". Journal of Autism and Developmental Disorders. 50 (3): 695–706. doi:10.1007/s10803-019-04298-1. ISSN 1573-3432. PMID 31732891. S2CID 208061795.
^ Kyriakou, Andreas; Nicolaides, Nicolas C.; Skordis, Nicos (2020). "Current approach to the clinical care of adolescents with gender dysphoria". Acta Bio Medica : Atenei Parmensis. 91 (1): 165–175. doi:10.23750/abm.v91i1.9244. ISSN 0392-4203. PMC 7569586. PMID 32191677.
^ Kaltiala-Heino, Riittakerttu; Bergman, Hannah; Työläjärvi, Marja; Frisén, Louise (2018-03-02). "Gender dysphoria in adolescence: current perspectives". Adolescent Health, Medicine and Therapeutics. 9: 31–41. doi:10.2147/AHMT.S135432. ISSN 1179-318X. PMC 5841333. PMID 29535563.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Diagnostic and Statistical Manual of Mental Disorders 5. American Psychiatric Association. 2013. p. 454. ISBN 978-0-89042-555-8.
^ Harvey Marcovitch, ed. (2018). "Gender Identity Disorders". Black's Medical Dictionary (43rd ed.). New York: Bloomsbury.
^ ^a ^b ^c ^d ^e ^f Zucker, Kenneth J. (2017). "Epidemiology of gender dysphoria and transgender identity". Sexual Health. 14 (5): 404–411. doi:10.1071/SH17067. ISSN 1448-5028. PMID 28838353.
^ Conron, KJ; Scott, G; Stowell, GS; Landers, S (January 2012), "Transgender Health in Massachusetts: Results from a Household Probability Sample of Adults", American Journal of Public Health, 102 (1), American Public Health Association: 118–222, doi:10.2105/AJPH.2011.300315, ISSN 1541-0048, OCLC 01642844, PMC 3490554, PMID 22095354, Between 2007 and 2009, survey participants aged 18 to 64 years in the Massachusetts Behavioral Risk Factor Surveillance System (MA-BRFSS; N = 28 662) were asked: "Some people describe themselves as transgender when they experience a different gender identity from their sex at birth. For example, a person born into a male body, but who feels female or lives as a woman. Do you consider yourself to be transgender?" ... We restricted the analytic sample to 28176 participants who answered yes or no to the transgender question (excluding n=364, 1.0% weighted who declined to respond. ... Transgender respondents (n=131; 0.5%; 95% confidence interval [CI]=0.3%, 0.6%) were somewhat younger and more likely to be Hispanic than were nontransgender respondents.
^ Clark TC, Lucassen MF, Bullen P, Denny SJ, Fleming TM, Robinson EM, Rossen FV (July 2014). "The health and well-being of transgender high school students: results from the New Zealand adolescent health survey (Youth'12)". The Journal of Adolescent Health. 55 (1): 93–9. doi:10.1016/j.jadohealth.2013.11.008. PMID 24438852. Whether a student was transgender was measured by the question, "Do you think you are transgender? This is a girl who feels like she should have been a boy, or a boy who feels like he should have been a girl (e.g., Trans, Queen, Fa'faffine, Whakawahine, Tangata ira Tane, Genderqueer)?" ... Over 8,000 students (n = 8,166) answered the question about whether they were transgender. Approximately 95% of students did not report being transgender (n=7,731; 94.7%), 96 students reported being transgender (1.2%), 202 reported not being sure (2.5%), and 137 did not understand the question (1.7%).
^ Landén M, Wålinder J, Lundström B (April 1996). "Prevalence, incidence and sex ratio of transsexualism". Acta Psychiatrica Scandinavica. 93 (4): 221–3. doi:10.1111/j.1600-0447.1996.tb10638.x. PMID 8712018. S2CID 26661088. On average, the male [to female]:female [to male] ratio in prevalence studies is estimated to be 3:1. However ... the incidence studies have shown a considerably lower male [to female] predominance. In Sweden and England and Wales, a sex ratio of 1:1 has been reported. In the most recent incidence data from Sweden, there is a slight male [to female] predominance among the group consisting of all applicants for sex reassignment, while in the group of primary [early onset] transsexuals there is no difference in incidence between men and women.
^ Koh J (2012). "[The history of the concept of gender identity disorder]". Seishin Shinkeigaku Zasshi = Psychiatria et Neurologia Japonica. 114 (6): 673–80. PMID 22844818.
^ Pauly, Ira B. (1993). "Terminology and Classification of Gender Identity Disorders". Journal of Psychology & Human Sexuality. 5 (4): 1–14. doi:10.1300/J056v05n04_01.
^ Drescher, Jack, Transsexualism, Gender Identity Disorder and the DSM, Journal of Gay & Lesbian Mental Health 14, no. 2 (2010): 112.
^ Bryant, Karl Edward (2007). The Politics of Pathology and the Making of Gender Identity Disorder. Ann Arbor, Michigan. p. 222. ISBN 978-0-549-26816-1.{{cite book}}: CS1 maint: location missing publisher (link)
^ ^a ^b Giordano, Simona (2012). Children with Gender Identity Disorder: A Clinical, Ethical, and Legal Analysis. New Jersey: Routledge. p. 147. ISBN 978-0-415-50271-9.
^ ^a ^b Vasey PL, Bartlett NH (2007). "What can the Samoan "Fa'afafine" teach us about the Western concept of gender identity disorder in childhood?". Perspectives in Biology and Medicine. 50 (4): 481–90. doi:10.1353/pbm.2007.0056. PMID 17951883. S2CID 37437172.
^ Diagnostic and Statistical Manual of Mental Disorders 5. American Psychiatric Association. 2013. p. 457. ISBN 978-0-89042-555-8.
^ Lev, Arlene Istar (2004). Transgender Emergence: Therapeutic Guidelines for Working with Gender-Variant People and Their Families. Haworth Press. p. 172. ISBN 978-0-7890-2117-5.
^ Rudacille, Deborah (February 2005). The Riddle of Gender: Science, Activism, and Transgender Rights. Pantheon. ISBN 978-0-375-42162-4.^{[page needed]}
^ Zucker, KJ; Spitzer, RL (Jan–Feb 2005), "Was the gender identity disorder of childhood diagnosis introduced into DSM-III as a backdoor maneuver to replace homosexuality? A historical note.", Journal of Sex and Marital Therapy, 31 (1): 31–42, doi:10.1080/00926230590475251, PMID 15841704, S2CID 22589255
^ ^a ^b "Controversy Continues to Grow Over DSM's GID Diagnosis". Psychiatric News.
^ Mallon, Gerald P. (2009). Social Work Practice with Transgender and Gender Variant Youth. New Jersey: Routledge. ISBN 978-0-415-99482-8.
^ "Government Policy concerning Transsexual People". People's rights/Transsexual people. U.K. Department for Constitutional Affairs. 2003. Archived from the original on May 11, 2008.
^ "La transsexualité ne sera plus classée comme affectation psychiatrique". Le Monde. May 16, 2009.
^ "La France est très en retard dans la prise en charge des transsexuels". Libération (in French). May 17, 2011. En réalité, ce décret n'a été rien d'autre qu'un coup médiatique, un très bel effet d'annonce. Sur le terrain, rien n'a changé.
^ Worley, Will (May 14, 2016). "Denmark will become first country to no longer define being transgender as a mental illness". The Independent.
^ Benestad, E.E.P. (October 2010). "From gender dysphoria to gender euphoria: An assisted journey". Sexologies. 19 (4): 225–231. doi:10.1016/j.sexol.2010.09.003. ISSN 1158-1360.
^ Hannan, M.D., Catherine; Collins, Donald; Whitington, Rayne (May 27, 2022). "Everything You Need to Know About Gender Affirming Care". Healthline.
^ "Sex vs. Gender: What's the Difference and Why Does it Matter?". Psych Central. 2022-05-12. Retrieved 2022-06-01.
^ Gittelson, Natalie (1979). Dominus: A Woman Looks at Men's Lives. Harcourt Brace Jovanovich. ISBN 978-0-15-626118-0.
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^ Aman, Reinhold (1988). Lillian Mermin Feinsilver Festschrift. Maledicta Press. ISBN 978-0-916500-29-0.
^ Transsexualism: A Collection of Articles, Editorials, and Letters on the Subject of Male-to-female and Female-to-male Transsexualism Edited from the TV-TS Tapestry Journal, Issues 39-52. International Foundation for Gender Education. 1988.
^ ^a ^b Transsexualism: A Collection of Articles, Editorials, and Letters on the Subject of Male-to-female and Female-to-male Transsexualism Edited from the TV-TS Tapestry Journal, Issues 39-52. University of Michigan: International Foundation for Gender Education. 1988.
^ Allen, Mariette Pathy (1989). Transformations: Crossdressers and Those who Love Them. Dutton. ISBN 978-0-525-24820-0.
^ Femme Mirror. 1990.
^ MacKenzie, Gordene Olga (1994). Transgender Nation. Popular Press. ISBN 978-0-87972-596-9.
^ Feinberg, Leslie (1999-10-10). Trans Liberation: Beyond Pink or Blue. Beacon Press. ISBN 978-0-8070-7951-5.
^ Ekins, Richard (1997). Male Femaling: A Grounded Theory Approach to Cross-dressing and Sex-changing. Psychology Press. ISBN 978-0-415-10624-5.
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^ Huit, T. Zachary; Ralston, Allura L.; Haws, J. Kyle; Holt, Natalie R.; Hope, Debra A.; Puckett, Jae A.; Mocarski, Richard A.; Woodruff, Nathan (2021-11-04). "Psychometric Evaluation of the Transgender Congruence Scale". Sexuality Research and Social Policy. doi:10.1007/s13178-021-00659-7. ISSN 1553-6610. S2CID 243792173.
^ Kozee, Holly B.; Tylka, Tracy L.; Bauerband, L. Andrew (June 2012). "Measuring Transgender Individuals' Comfort With Gender Identity and Appearance: Development and Validation of the Transgender Congruence Scale". Psychology of Women Quarterly. 36 (2): 179–196. doi:10.1177/0361684312442161. ISSN 0361-6843. S2CID 10564167.
^ "The joy that comes from embracing trans identity shouldn't be so rare | Andy Connor". the Guardian. 2019-01-25. Retrieved 2022-06-02.
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External links

Health Law Standards of Care for Transsexualism – An alternative to the Benjamin Standards of Care proposed by the International Conference on Transgender Law and Employment Policy.
The Lord Chancellor's Department Government Policy concerning Transsexual People

[DSM-5_fact_sheet-1] "Gender Dysphoria" (PDF). American Psychiatric Publishing. Retrieved December 24, 2016.

[Maddux-2] Maddux JE, Winstead BA (2015). Psychopathology: Foundations for a Contemporary Understanding. Routledge. pp. 464–465. ISBN 978-1317697992.

[Standards_of_Care-3] ^ ^a ^b ^c ^d ^e ^f Coleman E (2011). "Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7" (PDF). International Journal of Transgenderism. 13 (4). Routledge Taylor & Francis Group: 165–232. doi:10.1080/15532739.2011.700873. S2CID 39664779. Archived from the original (PDF) on August 2, 2014. Retrieved August 30, 2014.

[Davidson-2012-4] Davidson, Michelle R. (2012). A Nurse's Guide to Women's Mental Health. Springer Publishing Company. p. 114. ISBN 978-0-8261-7113-9.

[5] Campaign, Human Rights. "Sexual Orientation and Gender Identity Definitions".

[MorrowMessinger-6] Sexual Orientation and Gender Expression in Social Work Practice, edited by Deana F. Morrow and Lori Messinger (2006, ISBN 0231501862), p. 8: "Gender identity refers to an individual's personal sense of identity as masculine or feminine, or some combination thereof."

[7] American Psychiatric Association, DSM-5 Fact Sheets, Updated Disorders: Gender Dysphoria (Washington, D.C.: American Psychiatric Association, 2013): 2 ("DSM-5 aims to avoid stigma and ensure clinical care for individuals who see and feel themselves to be a different gender than their assigned gender. It replaces the diagnostic name 'gender identity disorder' with 'gender dysphoria', as well as makes other important clarifications in the criteria.").

[Russo-8] Russo J, Coker JK, King JH (2017). DSM-5® and Family Systems. Springer Publishing Company. p. 352. ISBN 978-0826183996. People meeting criteria for Gender Dysphoria most often identify themselves as trans or transgender. Trans or transgender can be used as umbrella terms to include the broad spectrum of persons whose gender identity differs from the assigned gender (APA, 2013).

[What_Is-9] Ranna Parekh. "What Is Gender Dysphoria?". American Psychiatric Publishing. Retrieved November 20, 2018.

[10] World Professional Association for Transgender Health (WPATH), Standards of Care for the Health of Transsexual, Transgender, and Gender Nonconforming People, ver. 7 (2011), 5 ("only some gender nonconforming people experience gender dysphoria at some point in their lives.")

[heylens_et_al-11] Heylens G, De Cuypere G, Zucker KJ, Schelfaut C, Elaut E, Vanden Bossche H, De Baere E, T'Sjoen G (March 2012). "Gender identity disorder in twins: a review of the case report literature". The Journal of Sexual Medicine. 9 (3): 751–7. doi:10.1111/j.1743-6109.2011.02567.x. PMID 22146048. Of 23 monozygotic female and male twins, nine (39.1%) were concordant for GID; in contrast, none of the 21 same‐sex dizygotic female and male twins were concordant for GID, a statistically significant difference (P = 0.005)... These findings suggest a role for genetic factors in the development of GID.

[diamond-2013-12] Diamond, Milton (2013). "Transsexuality Among Twins: Identity Concordance, Transition, Rearing, and Orientation". International Journal of Transgenderism. 14 (1): 24–38. doi:10.1080/15532739.2013.750222. S2CID 144330783. Combining data from the present survey with those from past-published reports, 20% of all male and female monozygotic twin pairs were found concordant for transsexual identity... The responses of our twins relative to their rearing, along with our findings regarding some of their experiences during childhood and adolescence show their identity was much more influenced by their genetics than their rearing.

[Rosenthal-2014-13] Rosenthal, Stephen M. (2014-12-01). "Approach to the Patient: Transgender Youth: Endocrine Considerations". The Journal of Clinical Endocrinology & Metabolism. 99 (12): 4379–4389. doi:10.1210/jc.2014-1919. ISSN 0021-972X. PMID 25140398.

[Karl_Bryant-14] Bryant, Karl (2018). "Gender Dysphoria". Encyclopædia Britannica Online. Retrieved August 16, 2018.

[Zack_Ford-15] Ford, Zack. "APA Revises Manual: Being Transgender is No Longer a Mental Disorder". ThinkProgress. Archived from the original on February 2, 2013. Retrieved April 7, 2013.

[16] Zucker, Kenneth J.; Lawrence, Anne A.; Kreukels, Baudewijntje P.C. (2016). "Gender Dysphoria in Adults". Annual Review of Clinical Psychology. 12: 217–247. doi:10.1146/annurev-clinpsy-021815-093034. PMID 26788901. [For DSM-5] a reconceptualization was articulated in which 'identity' per se was not considered a sign of a mental disorder. Rather, it was the incongruence between one's felt gender and assigned sex/gender (usually at birth) leading to distress and/or impairment that was the core feature of the diagnosis.

[17] Lev, Arlene Istar (2013). "Gender Dysphoria: Two Steps Forward, One Step Back". Clinical Social Work Journal. 41 (3): 288–296. doi:10.1007/s10615-013-0447-0. S2CID 144556484. [Despite some misgivings], I think that the change in nomenclature from the DSM-IV to the DSM-5 is a step forward, that is, removing the concept of gender as the site of the disorder and placing the focus on issues of distress and dysphoria.

[Guillamon-18] Guillamon A, Junque C, Gómez-Gil E (October 2016). "A Review of the Status of Brain Structure Research in Transsexualism". Archives of Sexual Behavior. 45 (7): 1615–48. doi:10.1007/s10508-016-0768-5. PMC 4987404. PMID 27255307.

[dsm5-19] Diagnostic and Statistical Manual of Mental Disorders (Fifth ed.). Arlington, VA: American Psychiatric Publishing. 2013. pp. 451–460. ISBN 978-0-89042-554-1.

[DSM5-20] ^ ^a ^b ^c ^d ^e ^f American Psychiatry Association (2013). Diagnostic and Statistical Manual of Mental Disorders (DSM-5) (5th ed.). Washington, DC and London: American Psychiatric Publishing. pp. 451–460. ISBN 978-0-89042-555-8.

[21] Diemer EW, Grant JD, Munn-Chernoff MA, Patterson DA, Duncan AE (August 2015). "Gender Identity, Sexual Orientation, and Eating-Related Pathology in a National Sample of College Students". The Journal of Adolescent Health. 57 (2): 144–9. doi:10.1016/j.jadohealth.2015.03.003. PMC 4545276. PMID 25937471.

[22] Harmon, A., & Oberleitner, M. G. (2016). Gender dysphoria. In Gale (Ed.), Gale encyclopedia of children's health: Infancy through adolescence (3rd ed.). Farmington, MI: Gale.

[treatment_review-23] Gijs, L; Brawaeys, A (2007). "Surgical Treatment of Gender Dysphoria in Adults and Adolescents: Recent Developments, Effectiveness, and Challenges". Annual Review of Sex Research. 18 (178–224).

[DSMVChild-24] "Gender Dysphoria in Children". American Psychiatric Association. May 4, 2011. Retrieved July 3, 2011.

[25] "P 00 Gender Dysphoria in Children". American Psychiatric Association. Retrieved April 2, 2012.

[Davy-26] Davy, Zowie; Toze, Michael (2018). "What Is Gender Dysphoria? A Critical Systematic Narrative Review". Transgender Health. 3 (1). Mary Ann Liebert, Inc. Publishers: 159–169. doi:10.1089/trgh.2018.0014. PMC 6225591. PMID 30426079.

[ICD-10-27] "International Classification of Diseases (ICD) F64 Gender identity disorders". World Health Organization. Retrieved August 9, 2018.

[28] Potts, S; Bhugra, D (1995). "Classification of sexual disorders". International Review of Psychiatry. 7 (2): 167–174. doi:10.3109/09540269509028323.

[29] "International Classification of Diseases". World Health Organization. Retrieved August 11, 2018.

[icd11-gc-30] "Gender incongruence (ICD-11)". icd.who.int. WHO. Retrieved August 28, 2018.

[pmid27717275-31] Reed GM, Drescher J, Krueger RB, Atalla E, Cochran SD, First MB, Cohen-Kettenis PT, Arango-de Montis I, Parish SJ, Cottler S, Briken P, Saxena S (October 2016). "Disorders related to sexuality and gender identity in the ICD-11: revising the ICD-10 classification based on current scientific evidence, best clinical practices, and human rights considerations". World Psychiatry. 15 (3): 205–221. doi:10.1002/wps.20354. PMC 5032510. PMID 27717275.

[NHS-32] "NHS - Treatment - Gender dysphoria". NHS. 2016. Retrieved January 10, 2019.

[Leiblum-2006-33] Leiblum, Sandra (2006). Principles and Practice of Sex Therapy, Fourth Edition. The Guilford Press. pp. 488–9. ISBN 978-1-59385-349-5.

[34] Heyes, C. J., & Latham, J. R. (2018). Trans surgeries and cosmetic surgeries: The politics of analogy. Transgender Studies Quarterly, 5(2), 174-189.

[AAP-35] Committee On Adolescence (July 2013). "Office-based care for lesbian, gay, bisexual, transgender, and questioning youth". Pediatrics. 132 (1): 198–203. doi:10.1542/peds.2013-1282. PMID 23796746. However, adolescents with multiple or anonymous partners, having unprotected intercourse, or having substance abuse issues should be tested at shorter intervals.

[GLMA-36] "www.glma.org Compendium of Health Profession Association LGBT Policy & Position Statements" (PDF). GLMA. 2013. Retrieved August 27, 2013.

[APA-37] "APA Policy Statements on Lesbian, Gay, Bisexual, & Transgender Concerns" (PDF). American Psychological Association. 2011. Retrieved August 27, 2013. Be it further resolved that APA recognizes the efficacy, benefit, and necessity of gender transition treatments for appropriately evaluated individuals and calls upon public and private insurers to cover these medically necessary treatments

[Lambda-38] "Health and Medical Organization Statements on Sexual Orientation, Gender Identity/Expression and 'Reparative Therapy'". lambdalegal.org. Lambda Legal.

[HRC-39] "Policy and Position Statements on Conversion Therapy". Human Rights Campaign. Human Rights Campaign. Retrieved 12 April 2017.

[APA_Position_2018-40] American Psychiatric Association (December 2018). "Position Statement on Therapies Focused on Attempts to Change Sexual Orientation (Reparative or Conversion Therapies)" (PDF). American Psychiatric Association. Archived from the original (PDF) on 10 December 2021. While many might identify as questioning, queer, or a variety of other identities, 'reparative' or conversion therapy is based on the a priori assumption that diverse sexual orientations and gender identities are mentally ill and should change ... APA encourages legislation which would prohibit the practice of 'reparative' or conversion therapies that are based on the a priori assumption that diverse sexual orientations and gender identities are mentally ill(references omitted)

[Ristori-41] Ristori, Jiska; Steensma, Thomas D. (2 January 2016). "Gender dysphoria in childhood". International Review of Psychiatry. 28 (1): 13–20. doi:10.3109/09540261.2015.1115754. PMID 26754056. S2CID 5461482.

[42] Kaltiala-Heino, Riittakerttu; Bergman, Hannah; Työläjärvi, Marja; Frisén, Louise (2018-03-02). "Gender dysphoria in adolescence: current perspectives". Adolescent Health, Medicine and Therapeutics. 9: 31–41. doi:10.2147/AHMT.S135432. ISSN 1179-318X. PMC 5841333. PMID 29535563. Evidence from the 10 available prospective follow-up studies from childhood to adolescence (reviewed in the study by Ristori and Steensma 28) indicates that for ~80% of children who meet the criteria for GDC, the GD recedes with puberty. Instead, many of these adolescents will identify as non-heterosexual.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[:9-43] Ristori, Jiska; Steensma, Thomas D. (2016). "Gender dysphoria in childhood". International Review of Psychiatry (Abingdon, England). 28 (1): 13–20. doi:10.3109/09540261.2015.1115754. ISSN 1369-1627. PMID 26754056. S2CID 5461482. As is shown in Table 1 there is much variation in the reported persistence rates between the studies, ranging from 2% to 39%. ... Based on this information, it seems reasonable to conclude that the persistence of GD may well be higher than 15%. However, desistence of GD still seems to be the case in the majority of children with GD.

[44] Temple Newhook, Julia; Pyne, Jake; Winters, Kelley; Feder, Stephen; Holmes, Cindy; Tosh, Jemma; Sinnott, Mari-Lynne; Jamieson, Ally; Pickett, Sarah (2018-04-03). "A critical commentary on follow-up studies and "desistance" theories about transgender and gender-nonconforming children". International Journal of Transgenderism. 19 (2): 212–224. doi:10.1080/15532739.2018.1456390. ISSN 1553-2739. S2CID 150338824.

[ashley_2021-45] Ashley, Florence (2021-09-02). "The clinical irrelevance of "desistance" research for transgender and gender creative youth". Psychology of Sexual Orientation and Gender Diversity. doi:10.1037/sgd0000504. ISSN 2329-0390. S2CID 239099559. Archived from the original on 3 March 2022. Retrieved 3 March 2022.

[temple-newhook-46] Newhook, Julia Temple; Pyne, Jake; Winters, Kelley; Feder, Stephen; Holmes, Cindy; Tosh, Jemma; Sinnott, Mari-Lynne; Jamieson, Ally; Pickett, Sarah (2018-04-03). "A critical commentary on follow-up studies and "desistance" theories about transgender and gender-nonconforming children". International Journal of Transgenderism. 19 (2): 212–224. doi:10.1080/15532739.2018.1456390. ISSN 1553-2739. S2CID 150338824.

[steensma_2018-47] Steensma, Thomas (2018). "A critical commentary on "A critical commentary on follow-up studies and "desistence" theories about transgender and gender non-conforming children"". International Journal of Transgenderism. 19 (2): 225–230. doi:10.1080/15532739.2018.1468292. S2CID 150062632 – via Taylor & Francis Online.

[Need-48] Butler, Catherine; Hutchinson, Anna (2020). "Debate: The pressing need for research and services for gender desisters/Detransitioners". Child and Adolescent Mental Health. 25 (1): 45–47. doi:10.1111/camh.12361. PMID 32285632. S2CID 210484832.

[Holcombe_2022-49] Holcombe, Madeline (2022-05-10). "Kids usually stay consistent when they socially transition young, according to a study". CNN. Retrieved 2022-06-07.

[50] The Transgendered Child: A Handbook for Families and Professionals (Brill and Pepper, 2008)^{[full citation needed]}^{[page needed]}

[Alleyne-51] Alleyne, Richard (15 April 2011). "Puberty blocker for children considering sex change". The Telegraph. Archived from the original on 2022-01-11. Retrieved 1 December 2020.

[52] Rew, Lynn; Young, Cara; Monge, Maria; Bogucka, Roxanne. "Review: Puberty blockers for transgender and gender diverse youth-a critical review of the literature". Child and Adolescent Mental Health. PMID 33320999. Positive outcomes were decreased suicidality in adulthood, improved affect and psychological functioning, and improved social life.

[53] "Evidence review: Gonadotrophin releasing hormone analogues for children and adolescents with gender dysphoria". Retrieved 2 April 2021. The critical outcomes for decision making are the impact on gender dysphoria, mental health and quality of life. The quality of evidence for these outcomes was assessed as very low certainty using modified GRADE.{{cite web}}: CS1 maint: url-status (link)

[54] "Finnish guidelines for treatment of child and adolescent gender dysphoria (published march 2021)" (PDF). Council for Choices in Health Care (COHERE). Retrieved 22 April 2021. p. 6: Terveydenhuoltolain mukaan (8§) terveydenhuollon toiminnan on perustuttava näyttöön ja hyviin hoito- ja toimintakäytäntöihin. Alaikäisten osalta tutkimusnäyttöön perustuvia terveydenhuollon menetelmiä ei ole. [According to the Health Care Act (Section 8), health care activities must be based on evidence and good care and operating practices. There are no research-based health care methods for minors. [translation provided by Wikipedia]]{{cite web}}: CS1 maint: url-status (link)

[55] Rafferty, Jason; Health, Committee on Psychosocial Aspects of Child and Family; Adolescence, Committee On; Section on Lesbian, Gay (2018-10-01). "Ensuring Comprehensive Care and Support for Transgender and Gender-Diverse Children and Adolescents". Pediatrics. 142 (4): e20182162. doi:10.1542/peds.2018-2162. ISSN 0031-4005. PMID 30224363.

[Safer-56] Safer, Joshua D. (17 February 2020). "Controversial pubertal blocker legislation may bring unintended consequences for children". Healio. Retrieved 15 December 2020.

[57] "AMA fights to protect health care for transgender patients". State Advocacy Update. American Medical Association. March 26, 2021.

[58] "Endocrine Society urges policymakers to follow science on transgender health: Texas custody case prompts unfounded claims". Endocrine Society (Press release). Washington, DC. October 28, 2019.

[59] "Criminalizing Gender Affirmative Care with Minors: Suggested Discussion Points With Resources to Oppose Transgender Exclusion Bills". American Psychological Association.

[60] "AACAP Statement Responding to Efforts to ban Evidence-Based Care for Transgender and Gender Diverse Youth". American Academy of Child and Adolescent Psychiatry. 8 November 2019.

[61] Schmidt, Samantha (22 April 2021). "FAQ: What you need to know about transgender children". The Washington Post.

[62] Siddique, Haroon (17 September 2021). "Appeal court overturns UK puberty blockers ruling for under-16s 17 September 2021". Guardian. Guardian. Retrieved 17 September 2021.

[:3-63] Kaltiala-Heino, Riittakerttu; Sumia, Maria; Työläjärvi, Marja; Lindberg, Nina (2015). "Two years of gender identity service for minors: overrepresentation of natal girls with severe problems in adolescent development". Child and Adolescent Psychiatry and Mental Health. 9: 9. doi:10.1186/s13034-015-0042-y. ISSN 1753-2000. PMC 4396787. PMID 25873995. for the majority of adolescent-onset cases, GD presented in the context of severe mental disorders and general identity confusion. In such situations, appropriate treatment for psychiatric comorbidities may be warranted before conclusions regarding gender identity can be drawn."; "There is still no clear consensus regarding hormonal treatment for adolescents because long-term data are unavailable"; "In a nationwide long-term follow-up study of adult cases, psychiatric morbidity, suicide attempts and suicide mortality persisted as elevated after juridical and medical SR.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[64] "Development of the diagnosis gender dysphoria" (PDF). Swedish National Board of Health and Welfare (in Swedish). Feb 2020. Retrieved 13 March 2021.{{cite web}}: CS1 maint: url-status (link)

[65] Kozlowska, Kasia; Chudleigh, Catherine; McClure, Georgia; Maguire, Ann M.; Ambler, Geoffrey R. (2021-01-12). "Attachment Patterns in Children and Adolescents With Gender Dysphoria". Frontiers in Psychology. 11: 582688. doi:10.3389/fpsyg.2020.582688. ISSN 1664-1078. PMC 7835132. PMID 33510668.

[66] D’Angelo, Roberto; Syrulnik, Ema; Ayad, Sasha; Marchiano, Lisa; Kenny, Dianna Theadora; Clarke, Patrick (2021-01-01). "One Size Does Not Fit All: In Support of Psychotherapy for Gender Dysphoria". Archives of Sexual Behavior. 50 (1): 7–16. doi:10.1007/s10508-020-01844-2. ISSN 1573-2800. PMC 7878242. PMID 33089441.

[merck_manual-67] George R. Brown, MD (July 20, 2011). "Chapter 165 Sexuality and Sexual Disorders". In Robert S. Porter, MD; et al. (eds.). The Merck Manual of Diagnosis and Therapy (19th ed.). Whitehouse Station, NJ, USA: Merck & Co., Inc. pp. 1740–1747. ISBN 978-0-911910-19-3.

[care_guidelines-68] Bockting, W; Knudson, G; Goldberg, J (January 2006). "Counselling and Mental Health Care of Transgender Adults and Loved Ones". International Journal of Transgenderism. 9 (3–4): 35–82. doi:10.1300/J485v09n03_03. S2CID 71503744. As per Figure 1, delusions about sex or gender, dissociative disorders, thought disorders,or obsessive or compulsive features should be evaluated and treated prior to proceeding with hormone therapy or surgery. Thought disorders, dissociative disorders, and obsessive-compulsive disorders can, rarely, cause a transient wish for sex reassignment which disappears or significantly lessens when the underlying mental health condition is treated. It is important to treat these disorders before proceeding with hormones or surgery to ensure that the desire for alteration of primary or secondary sex characteristics is not a temporary desire. See also WPATH Standards of Care, version 7, page 23: "The role of mental health professionals includes making reasonably sure that the gender dysphoria is not secondary to or better accounted for by other diagnoses." And the paradigmatic Dutch model for consideration of comorbid conditions before proceeding with treatment for childhood onset.

[SOC28-69] "Standards of Care for the Health of Transsexual, Transgender, and Gender Nonconforming People" (PDF). World Professional Association for Transgender Health. pp. 28–29. Retrieved 15 March 2021.

[Neuroimaging-70] Altinay, Murat; Anand, Amit (2020). "Neuroimaging gender dysphoria: a novel psychobiological model". Brain Imaging and Behavior. 14 (4): 1281–1297. doi:10.1007/s11682-019-00121-8. PMID 31134582. S2CID 167207854. Retrieved 2021-10-16. A recently published study (Colizzi et al. 2014), where 118 patients were followed before and 12 months after HRT revealed that 14% of the patients had comorbid Axis-I psychiatric diagnosis. Psychiatric distress and impairment were found to be higher in the beginning phase of the study but after HRT, there was a significant improvement in major depressive disorder, anxiety and functional impairment. Similarly, Fisher and colleagues' (Fisher et al. 2013) 2013 paper suggests that the dysfunction and impairment in the transgender population is highly associated with lack of HRT, which may suggest that at least a fraction of the impairment that was documented as comorbid Axis-I psychiatric disorders could in fact be impairment from GD. Finally, a metanalysis done by Dhejne and colleagues (Dhejne et al. 2016) reviewed 38 longitudinal studies that investigated psychiatric comorbidities pre and post gender affirmation treatments in transgender people with GD. The results of this analysis indicate that depression and GAD do have higher prevalence in transgender population but this finding was isolated to baseline (pre-gender affirmation treatments) where after gender affirmation therapies, rate of psychiatric comorbidities decreased to cisgender population levels

[71] Baker, Kellan E.; Wilson, Lisa M.; Sharma, Ritu; Dukhanin, Vadim; McArthur, Kristen; Robinson, Karen A. (2021). "Hormone Therapy, Mental Health, and Quality of Life Among Transgender People: A Systematic Review". Journal of the Endocrine Society. 5 (4): bvab011. doi:10.1210/jendso/bvab011. PMC 7894249. PMID 33644622. This systematic review of 20 studies found evidence that gender-affirming hormone therapy may be associated with improvements in QOL scores and decreases in depression and anxiety symptoms among transgender people. Associations were similar across gender identity and age. The strength of evidence for these conclusions is low due to methodological limitations.

[72] Wernick, Jeremy A.; Busa, Samantha; Matouk, Kareen; Nicholson, Joey; Janssen, Aron (2019-11-01). "A Systematic Review of the Psychological Benefits of Gender-Affirming Surgery". Urologic Clinics of North America. Gender Affirming Surgery. 46 (4): 475–486. doi:10.1016/j.ucl.2019.07.002. ISSN 0094-0143. PMID 31582022. S2CID 201997501.

[:5-73] Hembree, Wylie C; Cohen-Kettenis, Peggy T; Gooren, Louis; Hannema, Sabine E; Meyer, Walter J; Murad, M Hassan; Rosenthal, Stephen M; Safer, Joshua D; Tangpricha, Vin; T’Sjoen, Guy G (2017-11-01). "Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline". The Journal of Clinical Endocrinology & Metabolism. 102 (11): 3869–3903. doi:10.1210/jc.2017-01658. ISSN 0021-972X. PMID 28945902. In the future, we need more rigorous evaluations of the effectiveness and safety of endocrine and surgical protocols.Specifically, endocrine treatment protocols for GD/gender incongruence should include the careful assessment of the following: (1) the effects of prolonged delay of puberty in adolescents on bone health, gonadal function, and the brain (including effects on cognitive, emotional, social, and sexual development); [...] and (4) the risks and benefits of gender-affirming hormone treatment in older transgender people." "Future research is needed to ascertain the potential harm of hormonal therapies (176)." "The satisfaction rate with surgical reassignment of sex is now very high (187)." "Owing to the lack of controlled studies, incomplete follow-up, and lack of valid assessment measures, evaluating various surgical approaches and techniques is difficult." "Several postoperative studies report significant long-term psychological and psychiatric pathology (259–261)." "We need more studies with appropriate controls that examine long-term quality of life, psychosocial outcomes, and psychiatric outcomes to determine the long-term benefits of surgical treatment.

[74] Murad, Mohammad Hassan; Elamin, Mohamed B.; Garcia, Magaly Zumaeta; Mullan, Rebecca J.; Murad, Ayman; Erwin, Patricia J.; Montori, Victor M. (February 2010). "Hormonal therapy and sex reassignment: a systematic review and meta-analysis of quality of life and psychosocial outcomes". Clinical Endocrinology. 72 (2): 214–231. doi:10.1111/j.1365-2265.2009.03625.x. ISSN 1365-2265. PMID 19473181. S2CID 19590739. The evidence in this review is of very low quality9, 10 due to the serious methodological limitations of included studies. Studies lacked bias protection measures such as randomization and control groups, and generally depended on self-report to ascertain the exposure (i.e. hormonal therapy was self-reported as opposed to being extracted from medical records). Our reliance on reported outcome measures may also indicate a higher risk of reporting bias within the studies. Statistical heterogeneity of the results was also significant.

[75] Sutcliffe, P. A.; Dixon, S.; Akehurst, R. L.; Wilkinson, A.; Shippam, A.; White, S.; Richards, R.; Caddy, C. M. (March 2009). "Evaluation of surgical procedures for sex reassignment: a systematic review". Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS. 62 (3): 294–306, discussion 306–308. doi:10.1016/j.bjps.2007.12.009. ISSN 1878-0539. PMID 18222742. The evidence concerning gender reassignment surgery in both MTF and FTM transsexism has several limitations in terms of: (a) lack of controlled studies, (b) evidence has not collected data prospectively, (c) high loss to follow up and (d) lack of validated assessment measures. Some satisfactory outcomes were reported, but the magnitude of benefit and harm for individual surgical procedures cannot be estimated accurately using the current available evidence.

[76] Cohen-Kettenis, Peggy T.; Delemarre-van de Waal, Henriette A.; Gooren, Louis J. G. (2008). "The treatment of adolescent transsexuals: changing insights". The Journal of Sexual Medicine. 5 (8): 1892–1897. doi:10.1111/j.1743-6109.2008.00870.x. ISSN 1743-6109. PMID 18564158.

[77] Vries, Annelou L. C.; McGuire, Jenifer K.; Steensma, Thomas D.; Wagenaar, Eva C. F.; Doreleijers, Theo A. H.; Cohen-Kettenis, Peggy T. (2014). "Young adult psychological outcome after puberty suppression and gender reassignment". Pediatrics. 134 (4): 696–704. doi:10.1542/peds.2013-2958. ISSN 1098-4275. PMID 25201798. S2CID 18155489.

[78] Zucker, Kenneth J. (2019-10-01). "Adolescents with Gender Dysphoria: Reflections on Some Contemporary Clinical and Research Issues". Archives of Sexual Behavior. 48 (7): 1983–1992. doi:10.1007/s10508-019-01518-8. ISSN 1573-2800. PMID 31321594. S2CID 197663705. In the Dutch model, several factors were identified in deeming adolescent eligibility for early biomedical treatment. According to Cohen-Kettenis, Delemarre-van de Waal, and Gooren (2008), these included the following: (1) the presence of gender dysphoria from early childhood on; (2) an exacerbation of the gender dysphoria after the first signs of puberty; (3) the absence of psychiatric comorbidity that would interfere with a diagnostic evaluation or treatment; (4) adequate psychological and social support during treatment; and (5) a demonstration of knowledge of the sex/gender reassignment process. Several studies have reported on the benefits of this therapeutic protocol in reducing gender dysphoria (e.g., de Vries et al., 2014, which is the best study to date). Of course, one should bear in mind some of the limitation to these outcome studies, including the fact that not all assessed adolescents were deemed eligible for the treatment protocol (and thus we know relatively little about the longer-term outcomes of these youth) and that study designs have not included alternative treatment options (such as psychosocial therapy) or even being assigned to a wait-list control condition

[79] Haupt, Claudia; Henke, Miriam; Kutschmar, Alexia; Hauser, Birgit; Baldinger, Sandra; Saenz, Sarah Rafaela; Schreiber, Gerhard (2020-11-28). "Antiandrogen or estradiol treatment or both during hormone therapy in transitioning transgender women". Cochrane Database of Systematic Reviews. 2020 (11): CD013138. doi:10.1002/14651858.cd013138.pub2. ISSN 1465-1858. PMC 8078580. PMID 33251587. We found insufficient evidence to determine the efficacy or safety of hormonal treatment approaches for transgender women in transition.

[80] Baker, Kellan; Wilson, Lisa; Sharma, Ritu; Dukhanin, Vadim; McArthur, Kristen; Robinson, Karen (2021-02-02). "Hormone Therapy, Mental Health, and Quality of Life Among Transgender People: A Systematic Review". Journal of the Endocrine Society. 5 (4). Hormone therapy was associated with increased QOL, decreased depression, and decreased anxiety.

[81] Bustos, Valeria; Bustos, Samyd; Mascaro, Andres; Del Corral, Gabriel; Forte, Antonio; Ciudad, Pedro; Kim, Esther; Langstein, Howard; Manrique, Oscar (March 2021). "Regret after Gender-affirmation Surgery: A Systematic Review and Meta-analysis of Prevalence". Plastic and Reconstructive Surgery. 9 (3): e3477. doi:10.1097/GOX.0000000000003477. PMC 8099405. PMID 33968550. Archived from the original on 2022-04-06. Retrieved 2022-04-15.

[82] Janssen, Aron; Leibowitz, Scott (2018-05-22). Affirmative Mental Health Care for Transgender and Gender Diverse Youth: A Clinical Guide. Springer. p. 8. ISBN 978-3-319-78307-9.

[83] Coelho, Jennifer S; Suen, Janet; Clark, Beth A; et al. (October 15, 2019). "Eating Disorder Diagnoses and Symptom Presentation in Transgender Youth: A Scoping Review". Current Psychiatry Reports. 21 (11): 107. doi:10.1007/s11920-019-1097-x. PMID 31617014. S2CID 204542613 – via EBSCOhost. Significantly higher rates of eating disorder symptoms were documented in transgender youth compared to cisgender youth.

[:1-84] Thrower, Emily; Bretherton, Ingrid; Pang, Ken C.; Zajac, Jeffrey D.; Cheung, Ada S. (2020-03-01). "Prevalence of Autism Spectrum Disorder and Attention-Deficit Hyperactivity Disorder Amongst Individuals with Gender Dysphoria: A Systematic Review". Journal of Autism and Developmental Disorders. 50 (3): 695–706. doi:10.1007/s10803-019-04298-1. ISSN 1573-3432. PMID 31732891. S2CID 208061795.

[85] Kyriakou, Andreas; Nicolaides, Nicolas C.; Skordis, Nicos (2020). "Current approach to the clinical care of adolescents with gender dysphoria". Acta Bio Medica : Atenei Parmensis. 91 (1): 165–175. doi:10.23750/abm.v91i1.9244. ISSN 0392-4203. PMC 7569586. PMID 32191677.

[86] Kaltiala-Heino, Riittakerttu; Bergman, Hannah; Työläjärvi, Marja; Frisén, Louise (2018-03-02). "Gender dysphoria in adolescence: current perspectives". Adolescent Health, Medicine and Therapeutics. 9: 31–41. doi:10.2147/AHMT.S135432. ISSN 1179-318X. PMC 5841333. PMID 29535563.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[87] Diagnostic and Statistical Manual of Mental Disorders 5. American Psychiatric Association. 2013. p. 454. ISBN 978-0-89042-555-8.

[88] Harvey Marcovitch, ed. (2018). "Gender Identity Disorders". Black's Medical Dictionary (43rd ed.). New York: Bloomsbury.

[:0-89] ^ ^a ^b ^c ^d ^e ^f Zucker, Kenneth J. (2017). "Epidemiology of gender dysphoria and transgender identity". Sexual Health. 14 (5): 404–411. doi:10.1071/SH17067. ISSN 1448-5028. PMID 28838353.

[AJPH-90] Conron, KJ; Scott, G; Stowell, GS; Landers, S (January 2012), "Transgender Health in Massachusetts: Results from a Household Probability Sample of Adults", American Journal of Public Health, 102 (1), American Public Health Association: 118–222, doi:10.2105/AJPH.2011.300315, ISSN 1541-0048, OCLC 01642844, PMC 3490554, PMID 22095354, Between 2007 and 2009, survey participants aged 18 to 64 years in the Massachusetts Behavioral Risk Factor Surveillance System (MA-BRFSS; N = 28 662) were asked: "Some people describe themselves as transgender when they experience a different gender identity from their sex at birth. For example, a person born into a male body, but who feels female or lives as a woman. Do you consider yourself to be transgender?" ... We restricted the analytic sample to 28176 participants who answered yes or no to the transgender question (excluding n=364, 1.0% weighted who declined to respond. ... Transgender respondents (n=131; 0.5%; 95% confidence interval [CI]=0.3%, 0.6%) were somewhat younger and more likely to be Hispanic than were nontransgender respondents.

[91] Clark TC, Lucassen MF, Bullen P, Denny SJ, Fleming TM, Robinson EM, Rossen FV (July 2014). "The health and well-being of transgender high school students: results from the New Zealand adolescent health survey (Youth'12)". The Journal of Adolescent Health. 55 (1): 93–9. doi:10.1016/j.jadohealth.2013.11.008. PMID 24438852. Whether a student was transgender was measured by the question, "Do you think you are transgender? This is a girl who feels like she should have been a boy, or a boy who feels like he should have been a girl (e.g., Trans, Queen, Fa'faffine, Whakawahine, Tangata ira Tane, Genderqueer)?" ... Over 8,000 students (n = 8,166) answered the question about whether they were transgender. Approximately 95% of students did not report being transgender (n=7,731; 94.7%), 96 students reported being transgender (1.2%), 202 reported not being sure (2.5%), and 137 did not understand the question (1.7%).

[prevalence-92] Landén M, Wålinder J, Lundström B (April 1996). "Prevalence, incidence and sex ratio of transsexualism". Acta Psychiatrica Scandinavica. 93 (4): 221–3. doi:10.1111/j.1600-0447.1996.tb10638.x. PMID 8712018. S2CID 26661088. On average, the male [to female]:female [to male] ratio in prevalence studies is estimated to be 3:1. However ... the incidence studies have shown a considerably lower male [to female] predominance. In Sweden and England and Wales, a sex ratio of 1:1 has been reported. In the most recent incidence data from Sweden, there is a slight male [to female] predominance among the group consisting of all applicants for sex reassignment, while in the group of primary [early onset] transsexuals there is no difference in incidence between men and women.

[93] Koh J (2012). "[The history of the concept of gender identity disorder]". Seishin Shinkeigaku Zasshi = Psychiatria et Neurologia Japonica. 114 (6): 673–80. PMID 22844818.

[94] Pauly, Ira B. (1993). "Terminology and Classification of Gender Identity Disorders". Journal of Psychology & Human Sexuality. 5 (4): 1–14. doi:10.1300/J056v05n04_01.

[95] Drescher, Jack, Transsexualism, Gender Identity Disorder and the DSM, Journal of Gay & Lesbian Mental Health 14, no. 2 (2010): 112.

[:2-96] Bryant, Karl Edward (2007). The Politics of Pathology and the Making of Gender Identity Disorder. Ann Arbor, Michigan. p. 222. ISBN 978-0-549-26816-1.{{cite book}}: CS1 maint: location missing publisher (link)

[Giordano-2012-97] Giordano, Simona (2012). Children with Gender Identity Disorder: A Clinical, Ethical, and Legal Analysis. New Jersey: Routledge. p. 147. ISBN 978-0-415-50271-9.

[fa'afafine-98] Vasey PL, Bartlett NH (2007). "What can the Samoan "Fa'afafine" teach us about the Western concept of gender identity disorder in childhood?". Perspectives in Biology and Medicine. 50 (4): 481–90. doi:10.1353/pbm.2007.0056. PMID 17951883. S2CID 37437172.

[99] Diagnostic and Statistical Manual of Mental Disorders 5. American Psychiatric Association. 2013. p. 457. ISBN 978-0-89042-555-8.

[100] Lev, Arlene Istar (2004). Transgender Emergence: Therapeutic Guidelines for Working with Gender-Variant People and Their Families. Haworth Press. p. 172. ISBN 978-0-7890-2117-5.

[101] Rudacille, Deborah (February 2005). The Riddle of Gender: Science, Activism, and Transgender Rights. Pantheon. ISBN 978-0-375-42162-4.^{[page needed]}

[Historical_Note-102] Zucker, KJ; Spitzer, RL (Jan–Feb 2005), "Was the gender identity disorder of childhood diagnosis introduced into DSM-III as a backdoor maneuver to replace homosexuality? A historical note.", Journal of Sex and Marital Therapy, 31 (1): 31–42, doi:10.1080/00926230590475251, PMID 15841704, S2CID 22589255

[PsychNews-103] "Controversy Continues to Grow Over DSM's GID Diagnosis". Psychiatric News.

[104] Mallon, Gerald P. (2009). Social Work Practice with Transgender and Gender Variant Youth. New Jersey: Routledge. ISBN 978-0-415-99482-8.

[105] "Government Policy concerning Transsexual People". People's rights/Transsexual people. U.K. Department for Constitutional Affairs. 2003. Archived from the original on May 11, 2008.

[106] "La transsexualité ne sera plus classée comme affectation psychiatrique". Le Monde. May 16, 2009.

[107] "La France est très en retard dans la prise en charge des transsexuels". Libération (in French). May 17, 2011. En réalité, ce décret n'a été rien d'autre qu'un coup médiatique, un très bel effet d'annonce. Sur le terrain, rien n'a changé.

[108] Worley, Will (May 14, 2016). "Denmark will become first country to no longer define being transgender as a mental illness". The Independent.

[109] Benestad, E.E.P. (October 2010). "From gender dysphoria to gender euphoria: An assisted journey". Sexologies. 19 (4): 225–231. doi:10.1016/j.sexol.2010.09.003. ISSN 1158-1360.

[:6-110] Hannan, M.D., Catherine; Collins, Donald; Whitington, Rayne (May 27, 2022). "Everything You Need to Know About Gender Affirming Care". Healthline.

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[112] Gittelson, Natalie (1979). Dominus: A Woman Looks at Men's Lives. Harcourt Brace Jovanovich. ISBN 978-0-15-626118-0.

[113] Kriegel, Leonard (1979). On Men and Manhood. Hawthorn Books. ISBN 978-0-8015-0248-4.

[114] Aman, Reinhold (1986). Maledicta. Maledicta Press. ISBN 978-0-916500-29-0.

[115] Aman, Reinhold (1988). Lillian Mermin Feinsilver Festschrift. Maledicta Press. ISBN 978-0-916500-29-0.

[116] Transsexualism: A Collection of Articles, Editorials, and Letters on the Subject of Male-to-female and Female-to-male Transsexualism Edited from the TV-TS Tapestry Journal, Issues 39-52. International Foundation for Gender Education. 1988.

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[118] Allen, Mariette Pathy (1989). Transformations: Crossdressers and Those who Love Them. Dutton. ISBN 978-0-525-24820-0.

[119] Femme Mirror. 1990.

[120] MacKenzie, Gordene Olga (1994). Transgender Nation. Popular Press. ISBN 978-0-87972-596-9.

[121] Feinberg, Leslie (1999-10-10). Trans Liberation: Beyond Pink or Blue. Beacon Press. ISBN 978-0-8070-7951-5.

[122] Ekins, Richard (1997). Male Femaling: A Grounded Theory Approach to Cross-dressing and Sex-changing. Psychology Press. ISBN 978-0-415-10624-5.

[123] The Tartan Skirt: Magazine of the Scottish TV/TS Group. ADF Editorial Services. 1994.

[124] Califia, Patrick (1997). Sex Changes: The Politics of Transgenderism. Cleis Press. ISBN 978-1-57344-072-1.

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[127] Kozee, Holly B.; Tylka, Tracy L.; Bauerband, L. Andrew (June 2012). "Measuring Transgender Individuals' Comfort With Gender Identity and Appearance: Development and Validation of the Transgender Congruence Scale". Psychology of Women Quarterly. 36 (2): 179–196. doi:10.1177/0361684312442161. ISSN 0361-6843. S2CID 10564167.

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@@ Line 78: / Line 78: @@
 Medical, scientific, and governmental organizations have opposed [[conversion therapy]], defined as treatment viewing gender nonconformity as pathological and something to be changed, instead supporting approaches that affirm children's diverse gender identities.<ref name="Lambda">{{cite web|title=Health and Medical Organization Statements on Sexual Orientation, Gender Identity/Expression and 'Reparative Therapy'|url=https://www.lambdalegal.org/publications/health-and-med-orgs-stmts-on-sex-orientation-and-gender-identity|website=lambdalegal.org|publisher=Lambda Legal}}</ref><ref name="HRC">{{cite web|title=Policy and Position Statements on Conversion Therapy|url=http://www.hrc.org/resources/policy-and-position-statements-on-conversion-therapy|website=Human Rights Campaign|publisher=Human Rights Campaign|access-date=12 April 2017}}</ref><ref name="APA_Position_2018">{{cite web|title=Position Statement on Therapies Focused on Attempts to Change Sexual Orientation (Reparative or Conversion Therapies)|url=https://www.psychiatry.org/File%20Library/About-APA/Organization-Documents-Policies/Policies/Position-Conversion-Therapy.pdf|archive-url=https://web.archive.org/web/20211210052014/https://www.psychiatry.org/File%20Library/About-APA/Organization-Documents-Policies/Policies/Position-Conversion-Therapy.pdf |archive-date=10 December 2021|date=December 2018|author=American Psychiatric Association|publisher=[[American Psychiatric Association]] |quote=While many might identify as questioning, queer, or a variety of other identities, 'reparative' or conversion therapy is based on the a priori assumption that diverse sexual orientations and gender identities are mentally ill and should change ... APA encourages legislation which would prohibit the practice of 'reparative' or conversion therapies that are based on the a priori assumption that diverse sexual orientations and gender identities are mentally ill(references omitted)|author-link=American Psychiatric Association}}</ref> People are more likely to keep having gender dysphoria the more intense their gender dysphoria, cross-gendered behavior, and verbal identification with the desired/experienced gender are (i.e. stating that they ''are'' a different gender rather than ''wish to be'' a different gender).<ref name="Ristori">{{cite journal |last1=Ristori |first1=Jiska |last2=Steensma |first2=Thomas D. |title=Gender dysphoria in childhood |journal=International Review of Psychiatry |date=2 January 2016 |volume=28 |issue=1 |pages=13–20 |doi=10.3109/09540261.2015.1115754|pmid=26754056 |s2cid=5461482 }}</ref>
-The question of adult gender identity outcome is central to the treatment of gender dysphoria in children.<ref name="Ristori" /> A 2016 review of 10 prospective follow-up studies from childhood to adolescence found an average desistance rate of 85%, with rates varying widely between studies (from 61% to 98%).<ref>{{Cite journal|last1=Kaltiala-Heino|first1=Riittakerttu|last2=Bergman|first2=Hannah|last3=Työläjärvi|first3=Marja|last4=Frisén|first4=Louise|date=2018-03-02|title=Gender dysphoria in adolescence: current perspectives|journal=Adolescent Health, Medicine and Therapeutics|volume=9|pages=31–41|doi=10.2147/AHMT.S135432|issn=1179-318X|pmc=5841333|pmid=29535563|quote="Evidence from the 10 available prospective follow-up studies from childhood to adolescence (reviewed in the study by Ristori and Steensma 28) indicates that for ~80% of children who meet the criteria for GDC, the GD recedes with puberty. Instead, many of these adolescents will identify as non-heterosexual."}}</ref><ref name=":9">{{Cite journal|last1=Ristori|first1=Jiska|last2=Steensma|first2=Thomas D.|date=2016|title=Gender dysphoria in childhood|url=https://pubmed.ncbi.nlm.nih.gov/26754056/|journal=International Review of Psychiatry (Abingdon, England)|volume=28|issue=1|pages=13–20|doi=10.3109/09540261.2015.1115754|issn=1369-1627|pmid=26754056|s2cid=5461482|quote=As is shown in Table 1 there is much variation in the reported persistence rates between the studies, ranging from 2% to 39%. ... Based on this information, it seems reasonable to conclude that the persistence of GD may well be higher than 15%. However, desistence of GD still seems to be the case in the majority of children with GD.}}</ref> The review notes numerous methodological difficulties that arise when measuring desistance, including the variation in intensity of gender dysphoria among the children in the studies.<ref name="Ristori" />  These studies have been criticized on the grounds that they count as 'desistance' cases where the child met the criteria for gender identity disorder as defined in the [[DSM-III]] or [[DSM-IV]], but would not have met the updated criteria for gender dysphoria in the [[DSM-5]], established in 2013.<ref name="Ristori" /><ref>{{Cite journal|last1=Temple Newhook|first1=Julia|last2=Pyne|first2=Jake|last3=Winters|first3=Kelley|last4=Feder|first4=Stephen|last5=Holmes|first5=Cindy|last6=Tosh|first6=Jemma|last7=Sinnott|first7=Mari-Lynne|last8=Jamieson|first8=Ally|last9=Pickett|first9=Sarah|date=2018-04-03|title=A critical commentary on follow-up studies and "desistance" theories about transgender and gender-nonconforming children|url=https://www.tandfonline.com/doi/full/10.1080/15532739.2018.1456390|journal=International Journal of Transgenderism|language=en|volume=19|issue=2|pages=212–224|doi=10.1080/15532739.2018.1456390|s2cid=150338824|issn=1553-2739}}</ref>{{Explain|reason=What are the relevant differences between GID and GD?|date=June 2022}} Additionally, the evidence offered has been criticized for citing studies which have been labelled [[conversion therapy]] for discouraging [[Social transitioning|social transition]] and trying to prevent a transgender outcome. The [[DSM-5#Gender dysphoria|diagnostic criteria]] for gender dysphoria used in the studies only required gender-nonconformity, and did not require a child to state a transgender identity or a desire for [[Medical transition|medical]] or [[Social transitioning|social transition]].<ref name="ashley_2021">{{Cite journal |last=Ashley |first=Florence |date=2021-09-02 |title=The clinical irrelevance of "desistance" research for transgender and gender creative youth. |url=http://doi.apa.org/getdoi.cfm?doi=10.1037/sgd0000504 |journal=Psychology of Sexual Orientation and Gender Diversity |language=en |doi=10.1037/sgd0000504 |s2cid=239099559 |issn=2329-0390 |access-date=3 March 2022 |archive-date=3 March 2022 |archive-url=https://web.archive.org/web/20220303170812/http://doi.apa.org/doiLanding?doi=10.1037/sgd0000504 |url-status=live }}</ref><ref name=temple-newhook>{{Cite journal|last1=Newhook|first1=Julia Temple|last2=Pyne|first2=Jake|last3=Winters|first3=Kelley|last4=Feder|first4=Stephen|last5=Holmes|first5=Cindy|last6=Tosh|first6=Jemma|last7=Sinnott|first7=Mari-Lynne|last8=Jamieson|first8=Ally|last9=Pickett|first9=Sarah|date=2018-04-03|title=A critical commentary on follow-up studies and "desistance" theories about transgender and gender-nonconforming children|url=https://doi.org/10.1080/15532739.2018.1456390|journal=International Journal of Transgenderism|volume=19|issue=2|pages=212–224|doi=10.1080/15532739.2018.1456390 |s2cid=150338824|issn=1553-2739}}</ref><ref name="steensma_2018">{{Cite journal|last=Steensma|first=Thomas|date=2018|title=A critical commentary on "A critical commentary on follow-up studies and "desistence" theories about transgender and gender non-conforming children"|url=https://www.tandfonline.com/doi/full/10.1080/15532739.2018.1468292|journal=[[International Journal of Transgenderism]]|volume=19|issue=2|pages=225–230|doi=10.1080/15532739.2018.1468292|s2cid=150062632|via=Taylor & Francis Online}}</ref> Most childhood desisters go on to identify as [[cisgender]] and gay or lesbian.<ref name="Ristori" /><ref name="Need">{{Cite journal|last1=Butler|first1=Catherine|last2=Hutchinson|first2=Anna|year=2020|title=Debate: The pressing need for research and services for gender desisters/Detransitioners|journal=Child and Adolescent Mental Health|volume=25|issue=1|pages=45–47|doi=10.1111/camh.12361|pmid=32285632|s2cid=210484832}}</ref>
+A 2016 review of 10 prospective follow-up studies from childhood to adolescence found an average desistance rate of 85%, with rates varying widely between studies (from 61% to 98%).<ref>{{Cite journal|last1=Kaltiala-Heino|first1=Riittakerttu|last2=Bergman|first2=Hannah|last3=Työläjärvi|first3=Marja|last4=Frisén|first4=Louise|date=2018-03-02|title=Gender dysphoria in adolescence: current perspectives|journal=Adolescent Health, Medicine and Therapeutics|volume=9|pages=31–41|doi=10.2147/AHMT.S135432|issn=1179-318X|pmc=5841333|pmid=29535563|quote="Evidence from the 10 available prospective follow-up studies from childhood to adolescence (reviewed in the study by Ristori and Steensma 28) indicates that for ~80% of children who meet the criteria for GDC, the GD recedes with puberty. Instead, many of these adolescents will identify as non-heterosexual."}}</ref><ref name=":9">{{Cite journal|last1=Ristori|first1=Jiska|last2=Steensma|first2=Thomas D.|date=2016|title=Gender dysphoria in childhood|url=https://pubmed.ncbi.nlm.nih.gov/26754056/|journal=International Review of Psychiatry (Abingdon, England)|volume=28|issue=1|pages=13–20|doi=10.3109/09540261.2015.1115754|issn=1369-1627|pmid=26754056|s2cid=5461482|quote=As is shown in Table 1 there is much variation in the reported persistence rates between the studies, ranging from 2% to 39%. ... Based on this information, it seems reasonable to conclude that the persistence of GD may well be higher than 15%. However, desistence of GD still seems to be the case in the majority of children with GD.}}</ref>  The review notes numerous methodological difficulties that arise when measuring desistance, including the variation in intensity of gender dysphoria among the children in the studies.<ref name="Ristori" />  These studies have been criticized on the grounds that they count as 'desistance' cases where the child met the criteria for gender identity disorder as defined in the [[DSM-III]] or [[DSM-IV]], but would not have met the updated criteria for gender dysphoria in the [[DSM-5]], established in 2013.<ref name="Ristori" /><ref>{{Cite journal|last1=Temple Newhook|first1=Julia|last2=Pyne|first2=Jake|last3=Winters|first3=Kelley|last4=Feder|first4=Stephen|last5=Holmes|first5=Cindy|last6=Tosh|first6=Jemma|last7=Sinnott|first7=Mari-Lynne|last8=Jamieson|first8=Ally|last9=Pickett|first9=Sarah|date=2018-04-03|title=A critical commentary on follow-up studies and "desistance" theories about transgender and gender-nonconforming children|url=https://www.tandfonline.com/doi/full/10.1080/15532739.2018.1456390|journal=International Journal of Transgenderism|language=en|volume=19|issue=2|pages=212–224|doi=10.1080/15532739.2018.1456390|s2cid=150338824|issn=1553-2739}}</ref>{{Explain|reason=What are the relevant differences between GID and GD?|date=June 2022}} Additionally, the evidence offered has been criticized for citing studies which have been labelled [[conversion therapy]] for discouraging [[Social transitioning|social transition]] and trying to prevent a transgender outcome. The [[DSM-5#Gender dysphoria|diagnostic criteria]] for gender dysphoria used in the studies only required gender-nonconformity, and did not require a child to state a transgender identity or a desire for [[Medical transition|medical]] or [[Social transitioning|social transition]].<ref name="ashley_2021">{{Cite journal |last=Ashley |first=Florence |date=2021-09-02 |title=The clinical irrelevance of "desistance" research for transgender and gender creative youth. |url=http://doi.apa.org/getdoi.cfm?doi=10.1037/sgd0000504 |journal=Psychology of Sexual Orientation and Gender Diversity |language=en |doi=10.1037/sgd0000504 |s2cid=239099559 |issn=2329-0390 |access-date=3 March 2022 |archive-date=3 March 2022 |archive-url=https://web.archive.org/web/20220303170812/http://doi.apa.org/doiLanding?doi=10.1037/sgd0000504 |url-status=live }}</ref><ref name=temple-newhook>{{Cite journal|last1=Newhook|first1=Julia Temple|last2=Pyne|first2=Jake|last3=Winters|first3=Kelley|last4=Feder|first4=Stephen|last5=Holmes|first5=Cindy|last6=Tosh|first6=Jemma|last7=Sinnott|first7=Mari-Lynne|last8=Jamieson|first8=Ally|last9=Pickett|first9=Sarah|date=2018-04-03|title=A critical commentary on follow-up studies and "desistance" theories about transgender and gender-nonconforming children|url=https://doi.org/10.1080/15532739.2018.1456390|journal=International Journal of Transgenderism|volume=19|issue=2|pages=212–224|doi=10.1080/15532739.2018.1456390 |s2cid=150338824|issn=1553-2739}}</ref><ref name="steensma_2018">{{Cite journal|last=Steensma|first=Thomas|date=2018|title=A critical commentary on "A critical commentary on follow-up studies and "desistence" theories about transgender and gender non-conforming children"|url=https://www.tandfonline.com/doi/full/10.1080/15532739.2018.1468292|journal=[[International Journal of Transgenderism]]|volume=19|issue=2|pages=225–230|doi=10.1080/15532739.2018.1468292|s2cid=150062632|via=Taylor & Francis Online}}</ref> Most childhood desisters go on to identify as [[cisgender]] and gay or lesbian.<ref name="Ristori" /><ref name="Need">{{Cite journal|last1=Butler|first1=Catherine|last2=Hutchinson|first2=Anna|year=2020|title=Debate: The pressing need for research and services for gender desisters/Detransitioners|journal=Child and Adolescent Mental Health|volume=25|issue=1|pages=45–47|doi=10.1111/camh.12361|pmid=32285632|s2cid=210484832}}</ref> A 2021 study on transgender children who socially transitioned found that 7.3% detransition.<ref name="Holcombe 2022">{{cite web | last=Holcombe | first=Madeline | title=Kids usually stay consistent when they socially transition young, according to a study | website=CNN | date=2022-05-10 | url=https://www.cnn.com/2022/05/10/health/trans-youth-identity-parenting-wellness/index.html | access-date=2022-06-07}}</ref>
 Professionals who treat gender dysphoria in children sometimes prescribe [[puberty blocker]]s to delay the onset of puberty until a child is believed to be old enough to make an informed decision on whether hormonal or surgical gender reassignment is in their best interest.<ref>''The Transgendered Child: A Handbook for Families and Professionals'' (Brill and Pepper, 2008){{full citation needed|date=May 2016}}{{page needed|date=May 2016}}</ref><ref name="Alleyne">{{cite news |last1=Alleyne |first1=Richard |title=Puberty blocker for children considering sex change |url=https://www.telegraph.co.uk/news/health/news/8454002/Puberty-blocker-for-children-considering-sex-change.html |archive-url=https://ghostarchive.org/archive/20220111/https://www.telegraph.co.uk/news/health/news/8454002/Puberty-blocker-for-children-considering-sex-change.html |archive-date=2022-01-11 |url-access=subscription |url-status=live |access-date=1 December 2020 |work=The Telegraph |date=15 April 2011}}{{cbignore}}</ref>

Classification	D ICD-10: F64.9 , F64.8 ICD-9-CM: 302.85 MeSH: D000068116
External resources	MedlinePlus: 001527

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