THC Science

TAAR3P
Identifiers
Aliases	TAAR3P, GPR57, GPR58, TAAR2, TAAR3, trace amine associated receptor 3 (gene/pseudogene), trace amine associated receptor 3, pseudogene
External IDs	GeneCards: TAAR3P
Gene location (Human)
Chr.	Chromosome 6 (human)
End	132,609,302 bp
Orthologs
	9288
	n/a
	ENSG00000179073
	n/a
	n; a
	n/a
	NM_014627
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Putative trace amine-associated receptor 3 (TAAR3) is a human pseudogene with the gene symbol TAAR3P.^[3]^[4]^[5]^[6] In other species such as mice, TAAR3 is a functional protein-coding gene that encodes a trace amine-associated receptor protein.

Isobutylamine is a known ligand of TAAR3 in mice associated with sexual behaviour in male mice.^[7]

Isopentylamine was identified as a ligand for murine TAAR3 eliciting aversive behavior.^[8]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179073 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ HGNC:4513 Retrieved 28 November 2019
^ Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, et al. (February 2000). "Cloning and characterization of additional members of the G protein-coupled receptor family". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (3): 311–23. doi:10.1016/s0167-4781(99)00241-9. PMID 10684976.
^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
^ "Entrez Gene: TAAR3 trace amine associated receptor 3".
^ Harmeier A, Meyer CA, Staempfli A, Casagrande F, Petrinovic MM, Zhang YP, et al. (2018). "How Female Mice Attract Males: A Urinary Volatile Amine Activates a Trace Amine-Associated Receptor That Induces Male Sexual Interest". Frontiers in Pharmacology. 9: 924. doi:10.3389/fphar.2018.00924. PMC 6104183. PMID 30158871.
^ Liberles SD (October 2015). "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Current Opinion in Neurobiology. 34: 1–7. doi:10.1016/j.conb.2015.01.001. PMC 4508243. PMID 25616211.