Protein-coding gene in the species Homo sapiens
Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene .[5] [6] [7]
See also [ edit ] References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000155846 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033871 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O (Jan 2002). "Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus" . Diabetologia . 44 (12): 2220–6. doi :10.1007/s001250100032 PMID 11793024 . ^ Kressler D, Schreiber SN, Knutti D, Kralli A (Apr 2002). "The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha" . J Biol Chem . 277 (16): 13918–25. doi :10.1074/jbc.M201134200 PMID 11854298 . ^ "Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta" .
Further reading [ edit ]
Handschin C, Spiegelman BM (2007). "Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism" . Endocr. Rev . 27 (7): 728–35. doi :10.1210/er.2006-0037 PMID 17018837 . Esterbauer H, Oberkofler H, Krempler F, Patsch W (2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression". Genomics . 62 (1): 98–102. doi :10.1006/geno.1999.5977 . PMID 10585775 . Knutti D, Kaul A, Kralli A (2000). "A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen" . Mol. Cell. Biol . 20 (7): 2411–22. doi :10.1128/MCB.20.7.2411-2422.2000 . PMC 85422 PMID 10713165 . Lin J, Puigserver P, Donovan J, et al. (2002). "Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor" . J. Biol. Chem . 277 (3): 1645–8. doi :10.1074/jbc.C100631200 PMID 11733490 . Lacquemant C, Chikri M, Boutin P, et al. (2002). "No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians". Diabetologia . 45 (4): 602–3, author reply 604. doi :10.1007/s00125-002-0783-z . PMID 12032643 . Hara K, Tobe K, Okada T, et al. (2003). "A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes" . Diabetologia . 45 (5): 740–3. doi :10.1007/s00125-002-0803-z PMID 12107756 . Huss JM, Kopp RP, Kelly DP (2002). "Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha" . J. Biol. Chem . 277 (43): 40265–74. doi :10.1074/jbc.M206324200 PMID 12181319 . Hentschke M, Süsens U, Borgmeyer U (2003). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma". Biochem. Biophys. Res. Commun . 299 (5): 872–9. doi :10.1016/S0006-291X(02)02753-5 . PMID 12470660 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Shiraki T, Sakai N, Kanaya E, Jingami H (2003). "Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state" . J. Biol. Chem . 278 (13): 11344–50. doi :10.1074/jbc.M212859200 PMID 12551939 . Hammarstedt A, Jansson PA, Wesslau C, et al. (2003). "Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance". Biochem. Biophys. Res. Commun . 301 (2): 578–82. doi :10.1016/S0006-291X(03)00014-7 . PMID 12565902 . Meirhaeghe A, Crowley V, Lenaghan C, et al. (2003). "Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo" . Biochem. J . 373 (Pt 1): 155–65. doi :10.1042/BJ20030200 . PMC 1223480 PMID 12678921 . Patti ME, Butte AJ, Crunkhorn S, et al. (2003). "Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1" . Proc. Natl. Acad. Sci. U.S.A . 100 (14): 8466–71. Bibcode :2003PNAS..100.8466P . doi :10.1073/pnas.1032913100 PMC 166252 PMID 12832613 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Ling C, Poulsen P, Carlsson E, et al. (2004). "Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins" . J. Clin. Invest . 114 (10): 1518–26. doi :10.1172/JCI21889 . PMC 525741 PMID 15546003 . Andersen G, Wegner L, Yanagisawa K, et al. (2006). "Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity" . J. Med. Genet . 42 (5): 402–7. doi :10.1136/jmg.2004.026278 . PMC 1736055 PMID 15863669 . Staiger H, Staiger K, Haas C, et al. (2005). "Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro" . Diabetologia . 48 (10): 2115–8. doi :10.1007/s00125-005-1895-z PMID 16132959 . Wirtenberger M, Tchatchou S, Hemminki K, et al. (2006). "Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer" . Carcinogenesis . 27 (11): 2201–8. doi :10.1093/carcin/bgl067 PMID 16704985 .
External links [ edit ] This article incorporates text from the United States National Library of Medicine , which is in the public domain .
