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MTRF1
Identifiers
Aliases	MTRF1, MRF1, MTTRF1, RF1, mitochondrial translational release factor 1, mitochondrial translation release factor 1
External IDs	OMIM: 604601 MGI: 2384815 HomoloGene: 20903 GeneCards: MTRF1
Gene location (Human)
Chr.	Chromosome 13 (human)
End	41,263,577 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	79,661,027 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	n/a
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	9617
	211253
	ENSG00000120662
	ENSMUSG00000022022
	O75570; Q8N6Z2
	Q8K126
	NM_004294; NM_001354073; NM_001354074; NM_001354076
	NM_145960
	NP_004285; NP_001341002; NP_001341003; NP_001341005
	NP_666072
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.^[5]^[6]

The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120662 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022022 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang Y, Spremulli LL (November 1998). "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (1–2): 245–50. doi:10.1016/S0167-4781(98)00223-1. PMID 9838146.
^ Hansen LL, Jørgensen R, Justesen J (2000). "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics. 88 (1–2): 91–2. doi:10.1159/000015494. PMID 10773675. S2CID 1354562.

Further reading[edit]

Nozaki Y, Matsunaga N, Ishizawa T, et al. (2008). "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG". Genes Cells. 13 (5): 429–38. doi:10.1111/j.1365-2443.2008.01181.x. PMID 18429816. S2CID 21204094.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Soleimanpour-Lichaei HR, Kühl I, Gaisne M, et al. (2007). "mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG". Molecular Cell. 27 (5): 745–57. doi:10.1016/j.molcel.2007.06.031. PMC 1976341. PMID 17803939.
Young DJ, Edgar CD, Murphy J, et al. (2010). "Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria". RNA. 16 (6): 1146–55. doi:10.1261/rna.1970310. PMC 2874167. PMID 20421313.
Huynen, MA, Martijn; Duarte I; Chrzanowska-Lightowlers ZM; Nabuurs SB. (8 May 2012). "Structure based hypothesis of a mitochondrial ribosome rescue mechanism". Biology Direct. 7 (1): 14. doi:10.1186/1745-6150-7-14. PMC 3418547. PMID 22569235.
Lind, C; Sund J; Åqvist J (2013). "Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons". Nature Communications. 4: 2940. Bibcode:2013NatCo...4.2940L. doi:10.1038/ncomms3940. PMID 24352605.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120662 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022022 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9838146-5] Zhang Y, Spremulli LL (November 1998). "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (1–2): 245–50. doi:10.1016/S0167-4781(98)00223-1. PMID 9838146.

[pmid10773675-6] Hansen LL, Jørgensen R, Justesen J (2000). "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics. 88 (1–2): 91–2. doi:10.1159/000015494. PMID 10773675. S2CID 1354562.

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