Filorexant

Filorexant
Filorexant.svg
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard 100.203.042 Edit this at Wikidata
Chemical and physical data
Formula C24H25FN4O2
Molar mass 420.479 g/mol g·mol−1
3D model (JSmol)

Filorexant (INN, USAN) (code name MK-6096) is an orexin antagonist which is or was under development by Merck for the treatment of insomnia.[1] It is a dual antagonist of the OX1 and OX2 receptors.[2][3] As of March 2014, filorexant has completed phase II clinical trials.[4] It was also investigated as a migraine prophylaxis, but was not found effective,[5] and in major depressive disorder and painful diabetic neuropathy.[6] As of May 2015, filorexant is no longer listed on Merck‘s online development pipeline.[7]

See also[edit]

References[edit]

  1. ^ Hoyer D, Jacobson LH (December 2013). “Orexin in sleep, addiction and more: is the perfect insomnia drug at hand?”. Neuropeptides. 47 (6): 477–88. doi:10.1016/j.npep.2013.10.009. PMID 24215799.
  2. ^ Winrow CJ, Gotter AL, Cox CD, et al. (February 2012). “Pharmacological characterization of MK-6096 – a dual orexin receptor antagonist for insomnia”. Neuropharmacology. 62 (2): 978–87. doi:10.1016/j.neuropharm.2011.10.003. PMID 22019562.
  3. ^ Peroutka SJ (January 2014). “Clinical trials update. 2013: year in review”. Headache. 54 (1): 189–94. doi:10.1111/head.12267. PMID 24400767.
  4. ^ Cooper CK (March 2014). “Orexin Receptor Antagonists: Novel Hypnotic Agents”. Ment. Health. Clin. 4 (2): 64. ISSN 2168-9709.
  5. ^ Chabi, A.; Zhang, Y.; Jackson, S.; Cady, R.; Lines, C.; Herring, W. J.; Connor, K. M.; Michelson, D. (Aug 8, 2014). “Randomized controlled trial of the orexin receptor antagonist filorexant for migraine prophylaxis”. Cephalalgia. 35 (5): 379–88. doi:10.1177/0333102414544979. PMID 25106663.
  6. ^ Michel Alexander Steiner; Christopher J Winrow (11 November 2014). Insomnia and beyond – Exploring the therapeutic potential of orexin receptor antagonists. Frontiers E-books. pp. 3–. ISBN 978-2-88919-330-1.
  7. ^ “Merck Pipeline”. Merck. 2015. Retrieved 2015-05-14.

External links[edit]