THC Science

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Summary

DescriptionSteroidogenesis.png	English: Enzymes, their cellular location, substrates and products in human steroidogenesis. Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids. White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see Wikipedia:structural formula. HSD: Hydroxysteroid dehydrogenase References: Walter F. Boron, Emile L. Boulpaep (2003) Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, pp. page 1,300 ISBN: 1-4160-2328-3. For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis - Reference pathway (KO) from Kyoto University Bioinformatics Center. 1/11/13 There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase. Polski: Enzymy biorące udział w steroidogenezie. Uwagi: W miejscu gdzie stereochemia nie jest wyświetlana, jest taka sama jak dla Cholesterol lub w pokazanej powyżej grupie. HSD: Dehydrogenaza hydroksysteroidu
Date	28 March 2009
Source	Self-made using bkchem and inkscape
Author	David Richfield (User:Slashme) and Mikael Häggström. Derived from previous version by Hoffmeier and Settersr. In external use, this diagram may be cited as: Häggström M, Richfield D (2014). "Diagram of the pathways of human steroidogenesis". Wikiversity Journal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN 20018762.
Other versions	Derivative works of this file: Stereoidogenesis tr.png Steroidogenesis tr.png There is also an svg version (File:Steroidogenesis.svg), but since MediaWiki renders svg-images imperfectly, this image is first converted to a raster format to avoid ugly flaws in Wikipedia.

Evolution

A short flashback of some milestones the evolution of the picture, demonstrating the power of free licensing where anybody can contribute to making things better.

1. (March 2007) Previous image by Stannered.

5. (March 2009) Colouring and further organization by Mikael Häggström.

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Licensing

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File history

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	Date/Time	Dimensions	User	Comment
current	15:22, 13 March 2013	2,075 × 1,842 (940 KB)	Slashme	Removed link from corticosterone to cortisol via CYP17A1, which is incorrect (according to http://www.genome.jp/kegg-bin/show_pathway?ko00140+C02140 )
	16:15, 9 July 2012	2,075 × 1,842 (932 KB)	Mikael Häggström	Addition and correction of stereochemistries at positions 11 and 17.
	04:24, 9 July 2012	2,075 × 1,842 (928 KB)	Mikael Häggström	Added stereochemistries, removed redundant white circle at cortisol, renamed 21-alpha hydroxylase to simply 21-hydroxylase.
	05:17, 13 December 2011	1,314 × 1,166 (530 KB)	Slashme	Align some text and arrows for neatness' sake.
	05:03, 13 December 2011	1,314 × 1,166 (530 KB)	Slashme	Fixed reaction scheme: corticosterone doesn't go to cortisol! Karl and Lindie, why didn't you fix it when you first found out? Tsk tsk.
	12:56, 8 May 2010	1,314 × 1,162 (510 KB)	Mikael Häggström	minor renaming of 3-beta-HSD
	09:28, 18 April 2010	1,314 × 1,162 (510 KB)	Mikael Häggström	Moved pregnenolone out of molecular structure
	08:54, 1 November 2009	1,003 × 883 (253 KB)	Mikael Häggström	"Bunny-jumped", since the change earlier probably was too small to make it want to really update, but that misplaced 6 was important.
	08:53, 1 November 2009	621 × 767 (428 KB)	Mikael Häggström	see above
	08:49, 1 November 2009	1,003 × 883 (253 KB)	Mikael Häggström	moved misplaced nr 6