Protein-coding gene in the species Homo sapiens
Transforming growth factor beta-1-induced transcript 1 protein is a protein that in humans is encoded by the TGFB1I1 gene .[5] [6] TGFB1 . Studies suggest TGFB1I1 plays a role in processes of cell growth, proliferation,[7] [8] [9] [5] [7] [10] [11]
Functions [ edit ] Transforming growth factor beta-1-induced transcript 1 plays a role in a number of cell functions. Originally, TGFB1I1 was isolated as a senescence-inducing gene from mouse osteoblastic cells through treatment with transforming growth factor beta-1 and hydrogen peroxide.[9] [12] [13] [10] [14] [8] [15] [16]
Interactions [ edit ] TGFB1I1 has been shown to interact with:
See also [ edit ] References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000140682 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030782 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b c d Matsuya M, Sasaki H, Aoto H, Mitaka T, Nagura K, Ohba T, et al. (January 1998). "Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions" . The Journal of Biological Chemistry . 273 (2): 1003–1014. doi :10.1074/jbc.273.2.1003 PMID 9422762 . ^ Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, Chang C (March 1999). "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate" . The Journal of Biological Chemistry . 274 (12): 8316–8321. doi :10.1074/jbc.274.12.8316 PMID 10075738 . ^ a b Heitzer MD, DeFranco DB (July 2006). "Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells". Cancer Research . 66 (14): 7326–7333. doi :10.1158/0008-5472.can-05-2379 . PMID 16849583 . ^ a b Hu Y, Cascone PJ, Cheng L, Sun D, Nambu JR, Schwartz LM (August 1999). "Lepidopteran DALP, and its mammalian ortholog HIC-5, function as negative regulators of muscle differentiation" . Proceedings of the National Academy of Sciences of the United States of America . 96 (18): 10218–10223. Bibcode :1999PNAS...9610218H . doi :10.1073/pnas.96.18.10218 PMC 17869 PMID 10468589 . ^ a b Shibanuma M, Mashimo J, Kuroki T, Nose K (October 1994). "Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence" . The Journal of Biological Chemistry . 269 (43): 26767–26774. doi :10.1016/S0021-9258(18)47085-8 PMID 7929412 . ^ a b Yang L, Guerrero J, Hong H, DeFranco DB, Stallcup MR (June 2000). "Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix" . Molecular Biology of the Cell . 11 (6): 2007–2018. doi :10.1091/mbc.11.6.2007 . PMC 14899 PMID 10848625 . ^ Shibanuma M, Kim-Kaneyama JR, Ishino K, Sakamoto N, Hishiki T, Yamaguchi K, et al. (March 2003). "Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal" . Molecular Biology of the Cell . 14 (3): 1158–1171. doi :10.1091/mbc.02-06-0099 . PMC 151587 PMID 12631731 . ^ Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (April 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain" . The Journal of Biological Chemistry . 274 (14): 9847–9853. doi :10.1074/jbc.274.14.9847 PMID 10092676 . ^ Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". Journal of Cell Science . 112 ( Pt 2) (2): 181–190. doi :10.1242/jcs.112.2.181 . PMID 9858471 . ^ Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, Chang C (March 1999). "Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate" . The Journal of Biological Chemistry . 274 (12): 8316–8321. doi :10.1074/jbc.274.12.8316 PMID 10075738 . ^ Ohanian J, Pieri M, Ohanian V (September 2015). "Non-receptor tyrosine kinases and the actin cytoskeleton in contractile vascular smooth muscle" . The Journal of Physiology . 593 (17): 3807–3814. doi :10.1113/jphysiol.2014.284174 . PMC 4575570 PMID 25433074 . ^ Kim-Kaneyama JR, Lei XF, Arita S, Miyauchi A, Miyazaki T, Miyazaki A (2012). "Hydrogen peroxide-inducible clone 5 (Hic-5) as a potential therapeutic target for vascular and other disorders" . Journal of Atherosclerosis and Thrombosis . 19 (7): 601–607. doi :10.5551/jat.10736 PMID 22472216 . ^ a b Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, et al. (May 2002). "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator" . The Journal of Biological Chemistry . 277 (18): 15426–15431. doi :10.1074/jbc.M111218200 PMID 11856738 . ^ He B, Minges JT, Lee LW, Wilson EM (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators" . The Journal of Biological Chemistry . 277 (12): 10226–10235. doi :10.1074/jbc.M111975200 PMID 11779876 . ^ Carneiro AM, Ingram SL, Beaulieu JM, Sweeney A, Amara SG, Thomas SM, et al. (August 2002). "The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter" . The Journal of Neuroscience . 22 (16): 7045–7054. doi :10.1523/JNEUROSCI.22-16-07045.2002 PMC 6757888 PMID 12177201 . ^ Jia Y, Ransom RF, Shibanuma M, Liu C, Welsh MJ, Smoyer WE (October 2001). "Identification and characterization of hic-5/ARA55 as an hsp27 binding protein" . The Journal of Biological Chemistry . 276 (43): 39911–39918. doi :10.1074/jbc.M103510200 PMID 11546764 . ^ a b Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". Journal of Cell Science . 112 ( Pt 2) (2): 181–190. doi :10.1242/jcs.112.2.181 . PMID 9858471 . ^ Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K (August 2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase" . Molecular and Cellular Biology . 21 (16): 5332–5345. doi :10.1128/MCB.21.16.5332-5345.2001 . PMC 87257 PMID 11463817 . ^ Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (April 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain" . The Journal of Biological Chemistry . 274 (14): 9847–9853. doi :10.1074/jbc.274.14.9847 PMID 10092676 .
Further reading [ edit ]
Yeh S, Sampson ER, Lee DK, Kim E, Hsu CL, Chen YL, et al. (December 2000). "Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer". Journal of the Formosan Medical Association = Taiwan Yi Zhi . 99 (12): 885–894. PMID 11155740 . Heitzer MD, DeFranco DB (February 2007). "Hic-5/ARA55: a prostate stroma-specific AR coactivator". Steroids . 72 (2): 218–220. doi :10.1016/j.steroids.2006.11.010 . PMID 17166536 . S2CID 38796305 . Wilson SE, Lloyd SA (September 1991). "Epidermal growth factor and its receptor, basic fibroblast growth factor, transforming growth factor beta-1, and interleukin-1 alpha messenger RNA production in human corneal endothelial cells". Investigative Ophthalmology & Visual Science . 32 (10): 2747–2756. PMID 1716619 . Shibanuma M, Mashimo J, Kuroki T, Nose K (October 1994). "Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence" . The Journal of Biological Chemistry . 269 (43): 26767–26774. doi :10.1016/S0021-9258(18)47085-8 PMID 7929412 . Shibanuma M, Mochizuki E, Maniwa R, Mashimo J, Nishiya N, Imai S, et al. (March 1997). "Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts" . Molecular and Cellular Biology . 17 (3): 1224–1235. doi :10.1128/mcb.17.3.1224 . PMC 231847 PMID 9032249 . Fujita H, Kamiguchi K, Cho D, Shibanuma M, Morimoto C, Tachibana K (October 1998). "Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase" . The Journal of Biological Chemistry . 273 (41): 26516–26521. doi :10.1074/jbc.273.41.26516 PMID 9756887 . Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin". Journal of Cell Science . 112 ( Pt 2) (2): 181–190. doi :10.1242/jcs.112.2.181 . PMID 9858471 . Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (April 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain" . The Journal of Biological Chemistry . 274 (14): 9847–9853. doi :10.1074/jbc.274.14.9847 PMID 10092676 . Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, et al. (May 1999). "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling" . The Journal of Cell Biology . 145 (4): 851–863. doi :10.1083/jcb.145.4.851 . PMC 2133183 PMID 10330411 . Liu S, Thomas SM, Woodside DG, Rose DM, Kiosses WB, Pfaff M, Ginsberg MH (December 1999). "Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses". Nature . 402 (6762): 676–681. Bibcode :1999Natur.402..676L . doi :10.1038/45264 . PMID 10604475 . S2CID 2770368 . Yang L, Guerrero J, Hong H, DeFranco DB, Stallcup MR (June 2000). "Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix" . Molecular Biology of the Cell . 11 (6): 2007–2018. doi :10.1091/mbc.11.6.2007 . PMC 14899 PMID 10848625 . Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, et al. (May 2001). "CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk" . Blood . 97 (9): 2633–2639. doi :10.1182/blood.V97.9.2633 PMID 11313252 . Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K (August 2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase" . Molecular and Cellular Biology . 21 (16): 5332–5345. doi :10.1128/MCB.21.16.5332-5345.2001 . PMC 87257 PMID 11463817 . Jia Y, Ransom RF, Shibanuma M, Liu C, Welsh MJ, Smoyer WE (October 2001). "Identification and characterization of hic-5/ARA55 as an hsp27 binding protein" . The Journal of Biological Chemistry . 276 (43): 39911–39918. doi :10.1074/jbc.M103510200 PMID 11546764 . Ting HJ, Yeh S, Nishimura K, Chang C (January 2002). "Supervillin associates with androgen receptor and modulates its transcriptional activity" . Proceedings of the National Academy of Sciences of the United States of America . 99 (2): 661–666. Bibcode :2002PNAS...99..661T . doi :10.1073/pnas.022469899 PMC 117362 PMID 11792840 . Denhez F, Wilcox-Adelman SA, Baciu PC, Saoncella S, Lee S, French B, et al. (April 2002). "Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5" . The Journal of Biological Chemistry . 277 (14): 12270–12274. doi :10.1074/jbc.M110291200 PMID 11805099 . Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, et al. (May 2002). "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator" . The Journal of Biological Chemistry . 277 (18): 15426–15431. doi :10.1074/jbc.M111218200 PMID 11856738 .
External links [ edit ] This article incorporates text from the United States National Library of Medicine , which is in the public domain .
