Protein-coding gene in the species Homo sapiens
RING finger protein 4 is a protein that in humans is encoded by the RNF4 gene .[5] [6]
The protein encoded by this gene contains a RING finger domain and acts as a transcription factor . This protein has been shown to interact with, and inhibit the activity of, TRPS1 , a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor -dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis .[6]
Interactions [ edit ] RNF4 has been shown to interact with TCF20 ,[7] PATZ1 [8] [9] Androgen receptor .[9] [10] [11]
See also [ edit ] References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000063978 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029110 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Chiariotti L, Benvenuto G, Fedele M, Santoro M, Simeone A, Fusco A, Bruni CB (Jan 1998). "Identification and characterization of a novel RING-finger gene (RNF4) mapping at 4p16.3". Genomics . 47 (2): 258–65. doi :10.1006/geno.1997.5105 . PMID 9479498 . ^ a b "Entrez Gene: RNF4 ring finger protein 4" .^ Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P (Aug 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers" . The Journal of Biological Chemistry . 275 (34): 26144–9. doi :10.1074/jbc.M003405200 PMID 10849425 . ^ Fedele M, Benvenuto G, Pero R, Majello B, Battista S, Lembo F, Vollono E, Day PM, Santoro M, Lania L, Bruni CB, Fusco A, Chiariotti L (Mar 2000). "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor" . The Journal of Biological Chemistry . 275 (11): 7894–901. doi :10.1074/jbc.275.11.7894 PMID 10713105 . ^ a b Pero R, Lembo F, Palmieri EA, Vitiello C, Fedele M, Fusco A, Bruni CB, Chiariotti L (Feb 2002). "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription" . The Journal of Biological Chemistry . 277 (5): 3280–5. doi :10.1074/jbc.M109491200 PMID 11719514 . ^ Moilanen AM, Poukka H, Karvonen U, Häkli M, Jänne OA, Palvimo JJ (Sep 1998). "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription" . Molecular and Cellular Biology . 18 (9): 5128–39. doi :10.1128/mcb.18.9.5128 . PMC 109098 PMID 9710597 . ^ Poukka H, Aarnisalo P, Santti H, Jänne OA, Palvimo JJ (Jan 2000). "Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms" . The Journal of Biological Chemistry . 275 (1): 571–9. doi :10.1074/jbc.275.1.571 PMID 10617653 .
Further reading [ edit ]
Moilanen AM, Poukka H, Karvonen U, Häkli M, Jänne OA, Palvimo JJ (Sep 1998). "Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription" . Molecular and Cellular Biology . 18 (9): 5128–39. doi :10.1128/mcb.18.9.5128 . PMC 109098 PMID 9710597 . Hadano S, Ishida Y, Ikeda JE (Jun 1998). "The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3" . DNA Research . 5 (3): 177–86. doi :10.1093/dnares/5.3.177 PMID 9734812 . Poukka H, Aarnisalo P, Santti H, Jänne OA, Palvimo JJ (Jan 2000). "Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms" . The Journal of Biological Chemistry . 275 (1): 571–9. doi :10.1074/jbc.275.1.571 PMID 10617653 . Fedele M, Benvenuto G, Pero R, Majello B, Battista S, Lembo F, Vollono E, Day PM, Santoro M, Lania L, Bruni CB, Fusco A, Chiariotti L (Mar 2000). "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor" . The Journal of Biological Chemistry . 275 (11): 7894–901. doi :10.1074/jbc.275.11.7894 PMID 10713105 . Galili N, Nayak S, Epstein JA, Buck CA (May 2000). "Rnf4, a RING protein expressed in the developing nervous and reproductive systems, interacts with Gscl, a gene within the DiGeorge critical region" . Developmental Dynamics . 218 (1): 102–11. doi :10.1002/(SICI)1097-0177(200005)218:1<102::AID-DVDY9>3.0.CO;2-A PMID 10822263 . Lyngsø C, Bouteiller G, Damgaard CK, Ryom D, Sanchez-Muñoz S, Nørby PL, Bonven BJ, Jørgensen P (Aug 2000). "Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers" . The Journal of Biological Chemistry . 275 (34): 26144–9. doi :10.1074/jbc.M003405200 PMID 10849425 . Häkli M, Karvonen U, Jänne OA, Palvimo JJ (Jun 2001). "The RING finger protein SNURF is a bifunctional protein possessing DNA binding activity" . The Journal of Biological Chemistry . 276 (26): 23653–60. doi :10.1074/jbc.M009891200 PMID 11319220 . Saville B, Poukka H, Wormke M, Janne OA, Palvimo JJ, Stoner M, Samudio I, Safe S (Jan 2002). "Cooperative coactivation of estrogen receptor alpha in ZR-75 human breast cancer cells by SNURF and TATA-binding protein" . The Journal of Biological Chemistry . 277 (4): 2485–97. doi :10.1074/jbc.M109021200 PMID 11696545 . Pero R, Lembo F, Palmieri EA, Vitiello C, Fedele M, Fusco A, Bruni CB, Chiariotti L (Feb 2002). "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription" . The Journal of Biological Chemistry . 277 (5): 3280–5. doi :10.1074/jbc.M109491200 PMID 11719514 . Yan W, Hirvonen-Santti SJ, Palvimo JJ, Toppari J, Jänne OA (Oct 2002). "Expression of the nuclear RING finger protein SNURF/RNF4 during rat testis development suggests a role in spermatid maturation" . Mechanisms of Development . 118 (1–2): 247–53. doi :10.1016/S0925-4773(02)00261-7 PMID 12351196 . S2CID 15579434 . Pero R, Lembo F, Chieffi P, Del Pozzo G, Fedele M, Fusco A, Bruni CB, Chiariotti L (Sep 2003). "Translational regulation of a novel testis-specific RNF4 transcript". Molecular Reproduction and Development . 66 (1): 1–7. doi :10.1002/mrd.10322 . PMID 12874792 . S2CID 6206480 . Kaiser FJ, Möröy T, Chang GT, Horsthemke B, Lüdecke HJ (Oct 2003). "The RING finger protein RNF4, a co-regulator of transcription, interacts with the TRPS1 transcription factor" . The Journal of Biological Chemistry . 278 (40): 38780–5. doi :10.1074/jbc.M306259200 PMID 12885770 . Lin DY, Fang HI, Ma AH, Huang YS, Pu YS, Jenster G, Kung HJ, Shih HM (Dec 2004). "Negative modulation of androgen receptor transcriptional activity by Daxx" . Molecular and Cellular Biology . 24 (24): 10529–41. doi :10.1128/MCB.24.24.10529-10541.2004 . PMC 533990 PMID 15572661 .
External links [ edit ] 
